Organisation
Laboratory of Computational Biology (VIB-KU Leuven)
Division
Research in the Laboratory of Computational Biology is focusing on gene and genome regulation, with applications in Drosophila and cancer, and on integrative genomics, developing computational methods for genomic data integration and analysis of next-generation sequence data.
Current researchers
1 - 10 of 21 results
- Stein Aerts (Responsible)
- Darina Abaffyová (Member)
- Stein Aerts (Member)
- Sara Aibar Santos (Member)
- Cas Blaauw (Member)
- Carmen Bravo González-Blas (Member)
- Florian De Rop (Member)
- Seppe De Winter (Member)
- Hannah Dickmänken (Member)
- Sam Dieltiens (Member)
Projects
1 - 10 of 64
- Understanding gene regulation in a whole animal: From building a regulatory atlas to decoding gene regulation with deep learningFrom10 Jan 2024 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- SpaceTimeOmics: combining high-throughput spatial omics with AI to model gene regulation in space and timeFrom1 Jan 2024 → TodayFunding: FWO research project (including WEAVE projects)
- Interpretation of genomic regulatory variation in the human brain and Parkinson’s Disease by integrating deep learning with single-cell multi-omicsFrom1 Oct 2023 → TodayFunding: FWO junior postdoctoral fellowship
- Deep learning based synthetic design and massively parallel reporter assays to characterize and exploit cell type specific enhancersFrom1 Oct 2023 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Enhancer-AI: AI-driven modelling and design of cell type specific enhancers for gene therapyFrom1 Oct 2023 → TodayFunding: FWO Strategic Basic Research (SBO)
- Deep learning solutions for deciphering gene regulation in the human brainFrom7 Mar 2023 → TodayFunding: FWO Strategic Basic Research Grant
- The role of smORF encoded polypeptides in lager beer fermentationFrom1 Jan 2023 → TodayFunding: FWO research project (including WEAVE projects)
- Applications of deep learning for cancer genomicsFrom1 Jan 2023 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Evolution of the genomic regulatory code underlying neuronal diversityFrom1 Oct 2022 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- SymBioSys: Computationally mapping genomic heterogeneity from long read sequencing dataFrom1 Oct 2022 → TodayFunding: BOF - projects
Publications
21 - 30 of 177
- Decoding transcriptional states in cancer(2017)
Authors: Jasper Wouters, Zeynep Kalender Atak, Stein Aerts
Pages: 82 - 92 - Alteration of the microRNA network during the progression of Alzheimer's disease(2013)
Authors: Pierre Lau Poui Cheung, Evgenia Salta, Annerieke Sierksma, Amantha Thathiah, Smaragda Papadopoulou, Stein Aerts, Bart De Strooper
Pages: 1613 - 34 - Early alterations in the MCH system link aberrant neuronal activity and sleep disturbances in a mouse model of Alzheimer's disease(2023)
Authors: Nicky Thrupp, Mark Fiers, Joris de Wit, Kristofer Davie, Dietmar Thal, Bart De Strooper
Pages: 1021 - + - Variations in the exome of the LNCaP prostate cancer cell line(2012)
Authors: Lien Spans, Zeynep Kalender Atak, Evelyne Lerut, Stein Aerts, Frank Claessens
Pages: 1317 - 27 - Decoding gene regulation in the fly brain(2022)
Authors: Jasper Janssens, Ibrahim Ihsan Taskiran, Katina Spanier, Florian De Rop, Valerie Christiaens, Stein Aerts
Pages: 630 - + - DNA methylation repels binding of hypoxia-inducible transcription factors to maintain tumor immunotolerance(2020)
Authors: Laurien Van Dyck, Jieyi Xiong, Junbin Qian, Julie De Smedt, Liesbeth Minnoye, Marie De Borre, Peter Carmeliet, Bernard Thienpont, Diether Lambrechts
- Mapping gene regulatory networks from single-cell omics data(2018)
Authors: Mark Fiers, Liesbeth Minnoye, Carmen Bravo González-Blas, Zeynep Kalender Atak, Stein Aerts
Pages: 246 - 254 - ENDEAVOUR update : a web resource for gene prioritization in multiple species(2008)
Authors: Léon-Charles Tranchevent, Roland Barriot, Shi Yu, Steven Van Vooren, Peter Van Loo, Bert Coessens, Stein Aerts, Bart De Moor, Yves Moreau
Pages: 377 - 384 - SCENIC: single-cell regulatory network inference and clustering(2017)
Authors: Thomas Moerman, Hana Imrichova, Chris Marine, Jan Aerts, Joost van den Oord, Jasper Wouters, Stein Aerts
Pages: 1083 - + - Identification of Circulating Fibrocytes and Dendritic Derivatives in Corneal Endothelium of Patients With Fuchs' Dystrophy(2017)
Authors: An-Katrien De Roo, Jasper Wouters, Olivier Govaere, Beatrijs Foets, Joost van den Oord
Pages: 670 - 681