Organisation
Laboratory of Computational Biology (VIB-KU Leuven)
Division
Research in the Laboratory of Computational Biology is focusing on gene and genome regulation, with applications in Drosophila and cancer, and on integrative genomics, developing computational methods for genomic data integration and analysis of next-generation sequence data.
Current researchers
1 - 10 of 21 results
- Stein Aerts (Responsible)
- Darina Abaffyová (Member)
- Stein Aerts (Member)
- Sara Aibar Santos (Member)
- Cas Blaauw (Member)
- Carmen Bravo González-Blas (Member)
- Florian De Rop (Member)
- Seppe De Winter (Member)
- Hannah Dickmänken (Member)
- Sam Dieltiens (Member)
Projects
1 - 10 of 64
- Understanding gene regulation in a whole animal: From building a regulatory atlas to decoding gene regulation with deep learningFrom10 Jan 2024 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- SpaceTimeOmics: combining high-throughput spatial omics with AI to model gene regulation in space and timeFrom1 Jan 2024 → TodayFunding: FWO research project (including WEAVE projects)
- Interpretation of genomic regulatory variation in the human brain and Parkinson’s Disease by integrating deep learning with single-cell multi-omicsFrom1 Oct 2023 → TodayFunding: FWO junior postdoctoral fellowship
- Deep learning based synthetic design and massively parallel reporter assays to characterize and exploit cell type specific enhancersFrom1 Oct 2023 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Enhancer-AI: AI-driven modelling and design of cell type specific enhancers for gene therapyFrom1 Oct 2023 → TodayFunding: FWO Strategic Basic Research (SBO)
- Deep learning solutions for deciphering gene regulation in the human brainFrom7 Mar 2023 → TodayFunding: FWO Strategic Basic Research Grant
- The role of smORF encoded polypeptides in lager beer fermentationFrom1 Jan 2023 → TodayFunding: FWO research project (including WEAVE projects)
- Applications of deep learning for cancer genomicsFrom1 Jan 2023 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Evolution of the genomic regulatory code underlying neuronal diversityFrom1 Oct 2022 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- SymBioSys: Computationally mapping genomic heterogeneity from long read sequencing dataFrom1 Oct 2022 → TodayFunding: BOF - projects
Publications
11 - 20 of 177
- p53 induces formation of NEAT1 lncRNA-containing paraspeckles that modulate replication stress response and chemosensitivity(2016)
Authors: Carmen Adriaens, Jasmine Barra, Annelien Verfaillie, Bram Boeckx, Eleonora Leucci, Joost van den Oord, Anna Sablina, Diether Lambrechts, Stein Aerts, Chris Marine
Pages: 861 - 8 - Phenotype molding of stromal cells in the lung tumor microenvironment(2018)
Authors: Diether Lambrechts, Els Wauters, Bram Boeckx, David Nittner, Ayse Bassez, Andreas Pircher, Birgit Weynand, Erik Verbeken, Paul De Leyn, Adrian Liston, et al.
Pages: 1277 - + - Actuation enhances patterning in human neural tube organoids(2021)
Authors: Gregorius Andika Rustandi, Benjamin Gorissen, Kristofer Davie, Catherine Verfaillie, Maurilio Sampaolesi, Peter Dedecker, Hans Van Oosterwyck, Stein Aerts, Adrian Ranga
- The Atonal Proneural Transcription Factor Links Differentiation and Tumor Formation in Drosophila(2009)
Authors: Wouter Bossuyt, Natalie De Geest, Stein Aerts, Peter Marynen, Bassem Hassan
Pages: 301 - 310 - Genomic And Transcriptomic Analyses of Rare Lymphomas(2017)
Authors: Julio Finalet Ferreiro, Iwona Krajewska, Stein Aerts, Peter Vandenberghe
- Reduced synaptic vesicle protein degradation at lysosomes curbs TBC1D24/sky-induced neurodegeneration(2014)
Authors: Valerie Uytterhoeven, Yu-Chun Wang, Jan Slabbaert, Stein Aerts, Patrik Verstreken
Pages: 453 - 462 - Of Men and Water Fleas: Gene regulatory network discovery in human cancer and in an ecological context(2022)
Authors: Katina Spanier, Luc De Meester, Stein Aerts, Luisa Orsini
- Genomic adaptations to aquatic and aerial life in mayflies and the origin of insect wings(2020)
Authors: Kristofer Davie, Stein Aerts
- Neuronal cell types in the fly: single-cell anatomy meets single-cell genomics(2019)
Authors: Jasper Janssens, Stein Aerts
Pages: 125 - 134 - Computational Strategies for the Genome-Wide Identification of cis-Regulatory Elements and Transcriptional Targets(2012)
Authors: Stein Aerts
Pages: 121 - 45