Organisation
Laboratory of Computational Biology (VIB-KU Leuven)
Division
Research in the Laboratory of Computational Biology is focusing on gene and genome regulation, with applications in Drosophila and cancer, and on integrative genomics, developing computational methods for genomic data integration and analysis of next-generation sequence data.
Current researchers
1 - 10 of 21 results
- Stein Aerts (Responsible)
- Darina Abaffyová (Member)
- Stein Aerts (Member)
- Sara Aibar Santos (Member)
- Cas Blaauw (Member)
- Carmen Bravo González-Blas (Member)
- Florian De Rop (Member)
- Seppe De Winter (Member)
- Hannah Dickmänken (Member)
- Sam Dieltiens (Member)
Projects
1 - 10 of 64
- Understanding gene regulation in a whole animal: From building a regulatory atlas to decoding gene regulation with deep learningFrom10 Jan 2024 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- SpaceTimeOmics: combining high-throughput spatial omics with AI to model gene regulation in space and timeFrom1 Jan 2024 → TodayFunding: FWO research project (including WEAVE projects)
- Interpretation of genomic regulatory variation in the human brain and Parkinson’s Disease by integrating deep learning with single-cell multi-omicsFrom1 Oct 2023 → TodayFunding: FWO junior postdoctoral fellowship
- Deep learning based synthetic design and massively parallel reporter assays to characterize and exploit cell type specific enhancersFrom1 Oct 2023 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Enhancer-AI: AI-driven modelling and design of cell type specific enhancers for gene therapyFrom1 Oct 2023 → TodayFunding: FWO Strategic Basic Research (SBO)
- Deep learning solutions for deciphering gene regulation in the human brainFrom7 Mar 2023 → TodayFunding: FWO Strategic Basic Research Grant
- The role of smORF encoded polypeptides in lager beer fermentationFrom1 Jan 2023 → TodayFunding: FWO research project (including WEAVE projects)
- Applications of deep learning for cancer genomicsFrom1 Jan 2023 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Evolution of the genomic regulatory code underlying neuronal diversityFrom1 Oct 2022 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- SymBioSys: Computationally mapping genomic heterogeneity from long read sequencing dataFrom1 Oct 2022 → TodayFunding: BOF - projects
Publications
31 - 40 of 177
- Antitumor Immunity Triggered by Melphalan Is Potentiated by Melanoma Cell Surface-Associated Calreticulin(2015)
Authors: Gabriela Bomfim Ferreira, Jasper Wouters, Shaun Martin, Santeri Kiviluoto, Chantal Mathieu, Joost van den Oord, Marguerite Stas, Abhishek Garg, Patrizia Agostinis
Pages: 1603 - 1614 - The human melanoma side population displays molecular and functional characteristics of enriched chemoresistance and tumorigenesis(2013)
Authors: Jasper Wouters, Marguerite Stas, Olivier Govaere, Hannelore Maes, Patrizia Agostinis, Tania Roskams, Joost van den Oord, Hugo Vankelecom
- Mutation analysis of the tyrosine phosphatase PTPN2 in Hodgkin lymphoma and T-cell non-Hodgkin lymphoma(2011)
Authors: Ria Kleppe, Thomas Tousseyn, Zeynep Kalender Atak, Stein Aerts, Jan Cools
Pages: 1723 - 1727 - Cortical Neurogenesis Requires Bcl6-Mediated Transcriptional Repression of Multiple Self-Renewal-Promoting Extrinsic Pathways(2019)
Authors: Stein Aerts, Pierre Vanderhaeghen
Pages: 1096 - + - Cancer: Mutations close in on gene regulation(2013)
Authors: Stein Aerts, Jan Cools
Pages: 35 - 6 - Decoding gene regulation in the fly brain(2022)
Authors: Jasper Janssens, Stein Aerts, Jeroen Lammertyn
- High-throughput sequencing identifies aetiology-dependent differences in ductular reaction in human chronic liver disease(2019)
Authors: Olivier Govaere, Matthias Van Haele, Jasper Wouters, Wouter Van Delm, Werner Van Steenbergen, Diethard Monbaliu, Frederik Nevens, Tania Roskams
Pages: 66 - 76 - Six minute walk test in type III spinal muscular atrophy: a 12month longitudinal study(2013)
Authors: Marleen Van den Hauwe, Stein Aerts, Nathalie Goemans
Pages: 624 - 628 - Suz12 inactivation cooperates with JAK3 mutant signaling in the development of T-cell acute lymphoblastic leukemia(2019)
Authors: Michaël Broux, Cristina PRIETO FERNANDEZ, Sofie Demeyer, Marlies Vanden Bempt, Inge Lodewijckx, Roel Vandepoel, Jan Cools
Pages: 1323 - 1336 - Reverse engineering cellular identity at single-cell resolution(2023)
Authors: Carmen Bravo González-Blas, Stein Aerts, Georg Halder