Organisation
Laboratory of Computational Biology (VIB-KU Leuven)
Division
Research in the Laboratory of Computational Biology is focusing on gene and genome regulation, with applications in Drosophila and cancer, and on integrative genomics, developing computational methods for genomic data integration and analysis of next-generation sequence data.
Current researchers
1 - 10 of 21 results
- Stein Aerts (Responsible)
- Darina Abaffyová (Member)
- Stein Aerts (Member)
- Sara Aibar Santos (Member)
- Cas Blaauw (Member)
- Carmen Bravo González-Blas (Member)
- Florian De Rop (Member)
- Seppe De Winter (Member)
- Hannah Dickmänken (Member)
- Sam Dieltiens (Member)
Projects
1 - 10 of 64
- Understanding gene regulation in a whole animal: From building a regulatory atlas to decoding gene regulation with deep learningFrom10 Jan 2024 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- SpaceTimeOmics: combining high-throughput spatial omics with AI to model gene regulation in space and timeFrom1 Jan 2024 → TodayFunding: FWO research project (including WEAVE projects)
- Interpretation of genomic regulatory variation in the human brain and Parkinson’s Disease by integrating deep learning with single-cell multi-omicsFrom1 Oct 2023 → TodayFunding: FWO junior postdoctoral fellowship
- Deep learning based synthetic design and massively parallel reporter assays to characterize and exploit cell type specific enhancersFrom1 Oct 2023 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Enhancer-AI: AI-driven modelling and design of cell type specific enhancers for gene therapyFrom1 Oct 2023 → TodayFunding: FWO Strategic Basic Research (SBO)
- Deep learning solutions for deciphering gene regulation in the human brainFrom7 Mar 2023 → TodayFunding: FWO Strategic Basic Research Grant
- The role of smORF encoded polypeptides in lager beer fermentationFrom1 Jan 2023 → TodayFunding: FWO research project (including WEAVE projects)
- Applications of deep learning for cancer genomicsFrom1 Jan 2023 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Evolution of the genomic regulatory code underlying neuronal diversityFrom1 Oct 2022 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- SymBioSys: Computationally mapping genomic heterogeneity from long read sequencing dataFrom1 Oct 2022 → TodayFunding: BOF - projects
Publications
41 - 50 of 177
- A comprehensive inventory of TLX1 controlled long non-coding RNAs in T-cell acute lymphoblastic leukemia through polyA plus and total RNA sequencing(2018)
Authors: Simon Bornschein, Charles De Bock, Stein Aerts, Jan Cools
Pages: E585 - E589 - Epithelial-mesenchymal transition during invasion of cutaneous squamous cell carcinoma is paralleled by AKT activation(2014)
Authors: Kathleen Barrette, S Van Kelst, Jasper Wouters, Vivien Marasigan, Steffen Fieuws, Patrizia Agostinis, Joost van den Oord, Maria Garmyn
Pages: 1014 - 1021 - A Systems Map to Elucidate the Factors Influencing Vaccine Coverage(2019)
Authors: Florian De Rop, Jorge Ricardo Nova Blanco, Kaat Ramaekers, Corinne Vandermeulen
Pages: 115 - 150 - Keratin 19: a key role player in the invasion of human hepatocellular carcinomas(2014)
Authors: Olivier Govaere, MIna Komuta, Joost Berkers, Carl Janssen, Jasper Wouters, Chris Verslype, Baki Topal, Jacques Pirenne, Hugo Vankelecom, Frederik Nevens, et al.
Pages: 674 - 685 - Mitochondria metabolism sets the species-specific tempo of neuronal development(2023)
Authors: Ryohei Iwata, Pierre Casimir, Emir Erkol, Sofie Beckers, Anke Vandekeere, Pieter Vermeersch, Sebastien Carpentier, Kristofer Davie, Max Mazzone, Stein Aerts, et al.
Pages: 553 - + - The transcription factor Grainy head primes epithelial enhancers for spatiotemporal activation by displacing nucleosomes(2018)
Authors: Jelle Jacobs, Mardelle Atkins, Kristofer Davie, Hana Imrichova, Valerie Christiaens, Jasper Wouters, Ibrahim Ihsan Taskiran, Carmen Bravo González-Blas, Sara Aibar Santos, Georg Halder, et al.
Pages: 1011 - 1020 - Single-cell spatial multi-omics and deep learning dissect enhancer-driven gene regulatory networks in liver zonation(2024)
Authors: Roel Vandepoel, Valerie Christiaens, Jonas Demeulemeester, David Mauduit, Georg Halder, Stein Aerts
- Comparative analysis of antibody- and lipid-based multiplexing methods for single-cell RNA-seq(2022)
Authors: Isabelle Scheyltjens, Stein Aerts
- Tumor Vessel Normalization by Chloroquine Independent of Autophagy(2014)
Authors: Hannelore Maes, Anna Kuchnio, Aleksandar Peric, Stijn Moens, Kris Nys, Katrien De Bock, Annelies Quaegebeur, Sandra Schoors, Jasper Wouters, Hugo Vankelecom, et al.
Pages: 190 - 206 - LifeTime and improving European healthcare through cell-based interceptive medicine(2020)
Authors: Stein Aerts, Bart De Strooper, Chris Marine, Thierry Voet
Pages: 377 - 386