Projects
Developoing new tools for (un)structural biology by ion mobility-mass spectrometry and related methods.. University of Antwerp
Connecting the molecular structure and function of P4/P5B transport ATPases to neuronal cell biology KU Leuven
Research in the Laboratory of Cellular Transport Systems (Department of Cellular and Molecular Medicine; KU Leuven) focuses on P-type transport ATPases in mammalian organism including their role in human neurodegenerative diseases such as Parkinson’s disease. P-type ATPases are transport proteins that generate vital ion or lipid gradients across the plasma membrane or organellar membranes of nearly every cell in the organism. Our current ...
Cell biology of the endo-/lysosomal proteostasis in cancer and neurodegeneration (LYSOCaN). KU Leuven
PDZ networking in the biology of extracellular vesicles. KU Leuven
Exploring the endosomal transport dynamics of Telencephalin in neuronal dendrites: towards understanding the molecular cell biology of spine morphogenesis. KU Leuven
Synthetic biology and artificial intelligence, mutual learning to advance together and jointly drive industrial biotechnology - accelerating knowledge discovery and strain engineering Ghent University
This project aims the development of novel and innovativemachine learning and synthetic biology parts, tools and techniques by mutual learning, to jointly drive the strain engineering process. This ensemble will enable reliable forward engineering, which will be demonstrated by the development of a microbial cell factory for the flavonoid kaempferol.
Neuron-glia biology in neurodegeneration. KU Leuven
"The eye as a window to the brain” is the central theme of my research. I envision to focus on the interrelatedness of neurobiology and ophthalmology and to exploit this cross-over of disciplines to enrich fundamental research into central nervous system (CNS) function. By concentrating on the retina-brain axis, I will unravel mechanisms of intercellular communication in the CNS, with emphasis on neuronglia interactions. I will study these ...
Peroxisomal membrane dynamics in mammalian cells. KU Leuven
Membrane permeation and protein targets of peroxisome-derived hydrogen peroxide KU Leuven
Peroxisomes have the intrinsic ability to mediate and modulate hydrogen peroxide (H2O2)‐driven signaling events. Unfortunately, the mechanisms and functional consequences of peroxisomal H2O2 (dys)regulation remain far from understood. This project is intended to address this gap. Specifically, by employing a unique and powerful cell model that can be used to selectively generate H2O2 inside peroxisomes, we will search for proteins that ...