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Organisation

Medical Biochemistry (T_MBC)

Research Group

Lifecycle:1 Oct 2003  →  Today
Organisation profile:Proteolytic regulation of biological processes by endopeptidases and exopeptidases in human: isolation, expression, molecular characterization, functional exploration in vitro and in vivo, effects of inhibition, clinical and diagnostic applications, therapeutic drug target discovery.* Mechanism and pathophysiological role of the carboxypeptidase U pathway in fibrinolysis; study of related metallocarboxypeptidases (dirk.hendriks@ua.ac.be).* Functions of dipeptidylpeptidases in immunoregulation, diabetes, neuro-endocrine and metabolic processes in vitro and in vivo. (ingrid.demeester@ua.ac.be).* Structural, functional characterization of carboxy- and aminopeptidases: 3D molecular modeling, crystallography, mutagenesis, kinetic and physico-chemical analysis of substrate, ligand, inhibition, cofactor interactions, chemical modification. (anne-marie.lambeir@ua.ac.be).* Exocrine pancreas replacement in cystic fibrosis.Biological markers of affective disorders
Keywords:CARBOXYPEPTIDASE U, CARBOXYPEPTIDASE N, PROLYLOLIGOPEPTIDASES, DIPEPTIDYL PEPTIDASE, CARBOXYPEPTIDASE M, DRUG RESEARCH
Disciplines:Biochemistry and metabolism, Systems biology, Laboratory medicine, Medical biochemistry and metabolism