Cell biology of the endo-/lysosomal proteostasis in cancer and neurodegeneration (LYSOCaN).

Endo-/lysosomal proteostasis is a major cellular quality control mechanism that governs the degradation and recycling of proteins and lipids, the clearance of misfolded/aggregated proteins and dysfunctional organelles and secretion of proteolytic enzymes and intraluminal vesicles (exosomes) for intercellular communication. Their proper function is therefore related to cellular protection and increased life span and dysfunctions herein are increasingly recognized to underlie the etiopathology of neurodegenerative diseases and cancer. In the project we aim to investigate the effect of disease-associated proteins on lysosomal proteostasis and to identify modulators through profiling the biomolecular composition (proteome & lipidome) is isolated plasma membranes and lysosomes. We will search for differences and common mechanisms in cellular models of neurodegeneration (Alzheimers & Parkinsons disease) with epithelial-to-mesenchymal transition in melanoma.

Keywords:Cancer, oncology

Disciplines:Morphological sciences, Oncology