Projects
A multi-parametric esiRNA screen addressing reciprocal signalling in ES cell identity and neural conversion KU Leuven
Polypeptide growth factor signaling, such as exerted by the Transforming Growth Factor type b (TGFb) family system, is crucial to steer several processes within cells, including cell proliferation and differentiation, cell survival and cell death, and cell migration in embryogenesis, but also in adult tissue homeostasis and repair. The many extracellular ligands of this family provide these cues via binding to surface receptor complexes that ...
Nieuwe kernmerkextractie methoden voor de verbeterde analyse van magnetische resonantie spectroscopie en spectroscopische beeldvorming. KU Leuven
Non-invasive imaging to study atrial remodeling underlying the progressive nature of atrial fibrillation. KU Leuven
Advancing DNA-based antibody therapeutics through evaluation and characterization of in vivo expression, complex antibody formats, and delivery formulations KU Leuven
DNA-based antibody therapy seeks to administer the encoding nucleotide sequence, rather than the antibody protein. This innovative approach can allow the patient’s body to produce its own medicine, and presents an alternative to the complex production and frequent administration of conventional antibody protein therapy. Our research group previously obtained therapeutic proof of concept in mice for several plasmid-encoded antibody formats ...
Identification of microbial and cellular biomarkers for Short Bowel Syndrome in a combined in vitro-in vivo study Ghent University
Following extensive resection, the remaining small intestine may be of insufficient length to absorb nutrients, leading to short bowel syndrome (SBS). SBS is associated with significant malnutrition, and patients must take lifelong supplements. Funded by the Marie Skłodowska-Curie Actions programme, the SBS-microbe project aims to shed light on SBS pathogenesis, focusing on microbiota, metabolic and cellular changes occurring after resection. ...
Genome and transcriptome engineering with CRISPR/Cas as a precision medicine for Charcot-Marie-Tooth type 2L. University of Antwerp
Activity-based probes for PET imaging of protease activity. University of Antwerp
Ferroptosis monitoring and targeting in lung ischemia-reperfusion injury from mice to human. University of Antwerp
Fracture-related infection: optimization of diagnostic principles and the development of alternative strategies for prevention and treatment KU Leuven
Fracture-related infection (FRI) remains an important problem after musculoskeletal trauma surgery. At the center of these infections are microorganisms that form biofilms on the surface of implanted devices and necrotic bone. These biofilms shield the bacteria from the host immune system and are tolerant to most antibiotics, even in the absence of specific antibiotic resistance genes. All biofilm-related infections are, therefore, considered ...