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Organisation

Pathophysiology (T_PATHOFY)

Research Group

Lifecycle:1 Oct 2003  →  Today
Organisation profile:The most important lines of research that are currently running in the Laboratory of Experimental Pathophysiology deal with the following subjects:1. Bonemetabolism- Effect of a number of factors on the in vitro bone formation.- Research on the effect of a calcimimeticum on the evolution of renal osteodystrophy. - Role of the osteoblast on the development of renal osteodystrophy. A proteomics approach.- Effect of the uremic environment on the gastrointestinal absorption of lanthanum and its accumulation in a number of relevant organs and subcellular localisation in the liver.- Effect of the therapeutic use of lanthanum carbonate on the Ca-balance in comparison to other phosphate binding agents.- Drug discovery: Experimental research on the effect of a number of compounds in the prevention of osteoporosis in the rat. 2. Vascular calcification.- In vitro en in vivo research on the mechanisms underlying the development vascular calcification in chronic renal failure.- Comparative studies on the effect of a number of pharmaca on the development/reversibility of vascular calcifications in the chronic renal failure rat.- The calcification paradox: Experimental research on the role of the bone turn-over on the development of vascular calcifications.3. Cell biology of nephrocalcinosis and nephrolithiasis. - Research on the role of the tubular phenotype and the expression of number of relevant molecules in the development of tubular crystal retention.- Research on the potential role and alternative use of already existing pharmaca in the prevention of nephrocalcinosis.4. Characterisation and element mapping in mineral deposits of calcified tissues. 5. In vitro research on the renal transport and potential toxic effects of various pharmaca.- Research on the effects of an iron chelating compound on the tubular creatinine transport.6. Cell biological and experimental research on the mechanisms underlying the protective effect of a new erythropoietin compound in chronic renal failure.7. The role of epithelial to mesenchymal transition on the development of fibrosis in the transplant kidney.8. Epidemiological study on the cumulative toxic or protective effect of moderately increased multi-element exposure to heavy metals on a number of clinical/biochemical parameters.
Keywords:HISTOLOGY, BONE, VASCULAR CALCIFICATION, METALS, HISTOMORPHOMETRY, ANIMAL MODELS, PRIMARY CULTURES
Disciplines:Diagnostics, Intensive care and emergency medicine, Molecular and cell biology, Neurosciences, Oncology