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Bio-Imaging lab (T_BIM)
Main organisation:Department of Biomedical Sciences
Lifecycle:1 Oct 2003 → Today
Organisation profile:The core business of the bio-Imaging lab is high resolution in vivo neuro imaging. Using imaging methods we are focusing on early detection and underlying mechanisms of neurodegeneration using mice and rat models for different neurodegenerative pathologies such as Parkinson-, Huntington- and Alzheimer's disease. Secondly the attention goes to neuronal plasticity including adult neurogenesis and stem cell research in which we focus on in-vivo visualization and quantification of endogeneous and externally administered stem cell recruitment in rats, mice and songbirds using in vivo MRI and in vivo Bioluminiscence Imaging. Songbirds are further intensively studied as a model for seasonal and testosterone driven neuroplasticity, auditory processing and learning using the same imaging tools. Methods: The lab is equipped for in-vivo non invasive small animal imaging: 7Tesla 16 cm and a 9.4Tesla 20 cm horizontal bore Magnetic Resonance Imaging systems both from Bruker (Germany) and an in-vivo bioluminescence and Fluorescence camera from Biospace (France). The lab is also equipped for monitoring physiological parameters and EEG, anesthesia and small surgical intervention (such as stereotactic brain injections) in small animals.
Keywords:FMRI, NEURODEGENERATION, IN VIVO MRI, SONGBIRDS, MOLECULAR IMAGING, TRANSGENIC MICE, PHENOTYPE
Disciplines:Evolutionary biology , General biology, Medical imaging and therapy, Neurosciences, Social medical sciences, Other paramedical sciences, Biological and physiological psychology, Cognitive science and intelligent systems, Developmental psychology and ageing