Activity-based probes for PET imaging of protease activity.

Proteases are important drug targets and show increasing application as biomarkers for several diseases. Non-invasive imaging of their proteolytic activity status in vivo offers tremendous potential. We will develop activity-based imaging probes targeting proteases with relevance in oncology and inflammation. These probes will be used in a two-step approach in which the pretargeting step is followed by bioorthogonal ligation with a PET label.

Keywords:MOLECULAR IMAGING, ACTIVITY-BASED PROBE, MEDICINAL CHEMISTRY, PROTEASES

Disciplines:Biochemistry and metabolism, Systems biology, Medical biochemistry and metabolism, Medical imaging and therapy