Researcher
Maarten Dewilde
- Disciplines:Gene and molecular therapy, Medical molecular engineering of nucleic acids and proteins, Compound screening, In vitro testing, Non-clinical studies
Affiliations
- Therapeutic and Diagnostic Antibodies (Division)
Responsible
From1 Apr 2023 → Today - Therapeutic and Diagnostic Antibodies (Division)
Member
From1 Oct 2020 → Today
Projects
1 - 10 of 13
- MabMine: Breaking the barrier in conventional antibody discoveryFrom1 Jan 2024 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Improving specificity in gene therapy through nanobody coupling of AAV vectors.From1 Jan 2023 → 31 Dec 2023Funding: IOF - technology validation in lab
- PhD candidate to optimize the delivery of biologicals (antibodies) to the brainFrom1 Oct 2022 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Building a proprietary platform for DNA-antibody based therapeuticsFrom1 Oct 2022 → TodayFunding: IOF - technology validation in lab
- 161Tb-labeled radiopharmaceuticals targeting mucin receptors for treatment of pancreatic cancerFrom1 Oct 2022 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Towards brain cell selective drug targetingFrom1 Oct 2022 → TodayFunding: IOF - technology concept exploration
- H-ferritin nanoparticle-mediated VHH/mAb delivery across the blood-brain barrierFrom1 Sep 2022 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Rational design of biologics for therapeutic development (FoldCo)From19 Oct 2021 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Unlocking solute carriers for the biological's revolutionFrom1 Oct 2021 → TodayFunding: FWO Strategic Basic Research Grant
- Rational design of biologics for therapeutic development (FoldCo)From1 Oct 2021 → TodayFunding: FWO Strategic Basic Research (SBO)
Publications
1 - 10 of 16
- LRRC37B is a human modifier of voltage-gated sodium channels and axon excitability in cortical neurons(2023)
Authors: Sofie Beckers, Katerina Konstantoulea, Maarten Dewilde, Frederic Rousseau, Joost Schymkowitz, Tom Theys, Joris de Wit, Pierre Vanderhaeghen
- Selective inhibitors of the PSEN1-gamma-secretase complex.(2023)
Authors: Dries T'Syen, Maarten Dewilde, Bart De Strooper
Pages: 104794 - Novel Human/Non-Human Primate Cross-Reactive Anti-Transferrin Receptor Nanobodies for Brain Delivery of Biologics(2023)
Authors: Sam Noppen, Dominique Schols, Bart De Strooper, Maarten Dewilde
- Exploring the Fate of Antibody-Encoding pDNA after Intramuscular Electroporation in Mice(2023)
Authors: Marie-Lynn Cuypers, Nick Geukens, Paul Declerck, Maarten Dewilde
- Clinically relevant dosing and pharmacokinetics of DNA-encoded antibody therapeutics in a sheep model(2022)
Authors: Debby Thomas, Maarten Dewilde, Nick Geukens, Paul Declerck
- VHHs as tools for therapeutic protein delivery to the central nervous system(2022)
Authors: Bart De Strooper, Maarten Dewilde
- AAV-mediated delivery of an anti-BACE1 VHH alleviates pathology in an Alzheimer's disease model(2022)
Authors: Marika Marino, Jérôme Wahis, Lidia Yshii, Catherine Marneffe, Maarten Dewilde, Adrian Liston, Bart De Strooper, Matthew Holt
- Applicability of cerebral open flow microperfusion and microdialysis to quantify a brain-penetrating nanobody in mice(2021)
Authors: Maarten Dewilde
- Nanobodies to Cross the Blood-Brain Barrier(2021)
Authors: Yessica Wouters, Maarten Dewilde, Bart De Strooper
- Targeting Neuropilin-1 with Nanobodies Reduces Colorectal Carcinoma Development(2020)
Authors: Maarten Dewilde, Max Mazzone