- Coronary restenosis: clinical and experimental studies on restenosis of coronary arteries. - Myocardial infarction: clinical and experimental studies on coronary trombosis, limitation of infarct size, trombolytic agents, regulation of coronary blood flow and myocardial metabolism during ischemia and infarction. - Echocardiography: clinical and experimental studies on backscatter of ultrasound in diverse disease states; computerstudies on quantitative echocardiography. - Electrophysiology: studies on sudden death and its prevention. - Cardiac transplantation: studies on the metabolic consequences of immuno-suppressive therapy. - Heart rate variability: studies on mathematical models of heart rate variability in the experimental animal and man.