Projects
CRISParray : accelerating drug discovery through comprehensive cellular and molecular phenotyping Ghent University
The CRISParray platform provides solutions for both the targeting and phenotypic drug discovery pipelines. In this application, we will focus on the target discovery pipeline. On the scientific side, we aim to have a use case in the field of immunotherapy, to convince potential customers. In addition, they want to develop the necessary software to become a solution provider. At the same time, one builds on the existing IP/knowledge portfolio. ...
MachinE Learning Ledger Orchestration for Drug DiscoverY KU Leuven
MELLODDY will demonstrate how the pharmaceutical industry can better leverage its data assets to virtualize the Drug Discovery (DD) process with world-leading Machine Learning (ML) technologies as an answer to the ever-increasing challenges and stricter regulatory requirements it is facing. The lack of a tested, secure and privacy-preserving platform for federated machine learning that enables pharmaceutical partners to extract DD-relevant ...
Active learning and interpretation of computational model on tissue specific permeability for stock and virtual drug discovery library KU Leuven
Development and Application of Machine Learning and Statistical Methods for Chemical Drug Discovery KU Leuven
viability of new drug ligands. With the aide of Declarative Languages and
Artificial Intelligence (DTAI) and the Center for Drug Discovery Design (CD3). I will primarily apply statistical models and methods, such as Partial Least Squares, Principal Component Analysis and optimization methods like Support Vector Machines. The innovative methods I will derive and use ...
European Cooperation for anti-Viral Drug discovery and preparedness for current and emerging coronavirus outbreaks Institute of Tropical Medicine
Rational discovery of drug compounds targeting the chromatin-reading function of LEDGF/p75 towards the treatment for acute MLL-rearranged leukemia KU Leuven
Mixed-lineage leukemia rearranged (MLL-r) is an acute leukemia mostly affecting children and associated with poor survival. The disease is caused by rearrangements in the MLL gene resulting in malignant fusion proteins. LEDGF/p75 serves as an epigenetic reader and tethers transcription complexes containing MLL to chromatin via its PWWP domain. Recent studies demonstrated that this process is essential for the onset of MLL-r leukemia, yet it ...
Development and validation of a repurposing platform for drug discovery to treat cardiomyopathy. KU Leuven
Cardiovascular diseases (CVDs) are the leading cause of death worldwide. A subset of CVDs that remain particularly challenging to treat are cardiomyopathies (CMs) or ‘diseases of the heart muscle’. CMs are heterogeneous in origin and phenotype and mostly caused by an ever increasing number of gene mutations. The long-term benefits of current generalised pharmacological approaches are uncertain and these drugs only relieve symptoms instead of ...
Zebrafish platform for drug discovery and safety testing KU Leuven
The academic research activities of the Laboratory for Molecular Biodiscovery are focused on generating tailor-made zebrafish models of human diseases and zebrafish toxicity reporter lines with high valorisation potential. In a first valorization trajectory zebrafish models of human diseases (with an unmet clinical need) are used to discover novel lead compounds from libraries accessible via KU Leuven / EU-project partners / or industrial ...