From protease inhibitors with increased target residence time to activity-based probes: useful tools in different areas of drug discovery.

In this research project we aim to develop protease inhibitors that have the characteristics to become useful chemical tools in different areas of drug discovery. These tools will have the potential to be used in target discovery and target validation, hit and lead identification, for the identification of off-targets, as biomarkers and in molecular imaging.

Keywords:DRUG DISCOVERY, MEDICINAL CHEMISTRY, PROTEASE INHIBITOR

Disciplines:Organic chemistry, Biochemistry and metabolism, Systems biology, Medical biochemistry and metabolism, Biomarker discovery and evaluation, Drug discovery and development, Medicinal products, Pharmaceutics, Pharmacognosy and phytochemistry, Pharmacology, Pharmacotherapy, Toxicology and toxinology, Other pharmaceutical sciences