Researcher
Pieter Mestdagh
- Keywords:oncology, transcriptomics, RNA, non-coding RNA
- Disciplines:Analysis of next-generation sequence data, Cancer diagnosis, Cancer therapy, Molecular diagnostics, Development of bioinformatics software, tools and databases, Computational transcriptomics and epigenomics, Bioinformatics of disease, Bioinformatics data integration and network biology, Cancer biology, Transcription and translation, Epigenetics, Genome structure and regulation, Genetics
Affiliations
- Department of Biomolecular Medicine (Department)
Member
From1 Oct 2018 → Today - Department of Pediatrics and medical genetics (Department)
Member
From1 Oct 2006 → 30 Sep 2018
Projects
1 - 10 of 38
- Plasma cfRNA biomarker tail genes for cancer screening and monitoringFrom15 Oct 2023 → TodayFunding: IOF - technology concept exploration
- Increasing the value proposition of the IOF programs CRISParray and Amalus: CRISPRi-based target deconvolution of fibroblast modulatorsFrom15 Jul 2023 → TodayFunding: IOF - technology validation in lab
- Integration of molecular and cellular phenotypes: Optimizing complementarity of RNA-Seq and High Content Microscopy for the CRISParray platformFrom1 May 2023 → TodayFunding: IOF - technology concept exploration
- A new photoelectrochemical singlet oxygen-based detection platform for a panel of cancer biomarkers in tissue and liquid biopsies (SOCAN)From1 Jan 2023 → TodayFunding: BOF - iBOF
- Identifying lncRNA modulators of T-cell activation to enhance immune-checkpoint inhibition therapyFrom1 Jan 2023 → TodayFunding: Foundations, funds and other with scientific goal
- Long non-coding RNA modulators of tumor immune evasionFrom1 Jan 2023 → TodayFunding: FWO research project (including WEAVE projects)
- Incucyte S3: Comprehensive cellular phenotyping using high-throughput live cell imagingFrom15 Dec 2022 → TodayFunding: BOF - scientific equipment program
- Functional study of a novel, long non-coding RNA (lncRNA) upstream of ABCA4 in retina and blindnessFrom1 Nov 2022 → TodayFunding: BOF - doctoral mandates
- Mapping and disrupting molecular interactions with the long non-coding RNA NESPR in neuroblastomaFrom1 Oct 2022 → TodayFunding: BOF - postdoctoral mandates
- CRISParray : accelerating drug discovery through comprehensive cellular and molecular phenotypingFrom1 Aug 2022 → TodayFunding: IWT / VLAIO personal funding - innovation mandates
Publications
1 - 10 of 261
- Direct lysis of 3D cell cultures for RT-qPCR gene expression quantification(2023)
Authors: Fien Gysens, Lisa Ostyn, Ellen Goeteyn, Eva Blondeel, Justine Nuytens, Olivier De Wever, Eric de Bony de Lavergne, Aurélie Crabbé, Pieter Mestdagh
- Blocking abundant RNA transcripts by high-affinity oligonucleotides during transcriptome library preparation(2023)
Authors: Celine Everaert, Jasper Verwilt, Kimberly Verniers, Niels Vandamme, Alvaro Marcos Rubio, Jo Vandesompele, Pieter Mestdagh
- Benchmarking blood collection tubes and processing intervals for extracellular vesicle performance metrics(2023)
Authors: Edward Geeurickx, Joeri Tulkens, Glenn Vergauwen, Edwin Van Der Pol, Rienk Nieuwland, Ilkka Miinalainen, Pekka Rappu, Gary Schroth, Scott Kuersten, Pieter Mestdagh, et al.
- Performance evaluation of RNA purification kits and blood collection tubes in the Extracellular RNA Quality Control (exRNAQC) study(2023)
Authors: Anneleen Decock, Olivier De Wever, Celine Everaert, Hetty Helsmoortel, An Hendrix, Pieter Mestdagh, Annelien Morlion, Jo Vandesompele, Ruben Van Paemel, Francisco Avila Cobos, et al.
Number of pages: 1 - Performance evaluation of RNA purification kits and blood collection tubes in the Extracellular RNA Quality Control (exRNAQC) study(2023)
Authors: Anneleen Decock, Olivier De Wever, Celine Everaert, Hetty Helsmoortel, An Hendrix, Pieter Mestdagh, Annelien Morlion, Jo Vandesompele, Ruben Van Paemel, Francisco Avila Cobos, et al.
Number of pages: 1 - Artifacts and biases of the reverse transcription reaction in RNA sequencing(2023)
Authors: Jasper Verwilt, Pieter Mestdagh, Tom Cech
Pages: 889 - 897 - Dramatic impact of blood collection tube and RNA purification method on extracellular RNA transcriptomes(2023)
Authors: Jasper Anckaert, Francisco Avila Cobos, Anneleen Decock, Philippe Decruyenaere, Jill Deleu, Katleen De Preter, Olivier De Wever, Jilke De Wilde, Bert Dhondt, Thibaut D'huyvetter, et al.
Number of pages: 1 - Open problems in extracellular RNA data analysis : insights from an ERCC online workshop(2022)
Authors: Roger P. Alexander, Robert R. Kitchen, Juan Pablo Tosar, Matthew Roth, Pieter Mestdagh, Klaas E. A. Max, Joel Rozowsky, Karolina Elzbieta Kaczor-Urbanowicz, Justin Chang, Leonora Balaj, et al.
- Reliable and scalable SARS-CoV-2 qPCR testing at a high sample throughput : lessons learned from the Belgian initiative(2022)
Authors: Steven Van Vooren, James Grayson, Marc Van Ranst, Elisabeth Dequeker, Lies Laenen, Reile Janssen, Laurent Gillet, Fabrice Bureau, Wouter Coppieters, Nathalie Devos, et al.
- A 3′‐end capture sequencing method for high‐throughput targeted gene expression profiling(2022)
Authors: Eric de Bony de Lavergne, Fien Gysens, Nurten Yigit, Jasper Anckaert, Celine Everaert, Eveline Vanden Eynde, Kimberly Verniers, Willem van Snippenberg, Wim Trypsteen, Pieter Mestdagh
Patents
1 - 9 of 9
- Inhibition of a lncRNA for treatment of neuroblastoma (Inventor)
- Inhibition of a lncRNA for treatment of melanoma (Inventor)
- Combinations of therapeutic agents for treating uveal melanoma (Inventor)
- Biomarkers for disease burden of neuroblastoma (Inventor)
- Usages of recombinant extracellular vesicles (Inventor)
- Inhibition of a lncRNA for treatment of neuroblastoma (Inventor)
- Biomarkers for disease burden of neuroblastoma (Inventor)
- Usages of recombinant extracellular vesicles (Inventor)
- Inhibition of a lncRNA for treatment of melanoma (Inventor)