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Researcher
Sergei Strelkov
- Disciplines:Analytical chemistry, Medicinal and biomolecular chemistry, Biochemistry and metabolism, Molecular and cell biology, Plant biology, Systems biology, Biophysics, Medical biochemistry and metabolism, Biomarker discovery and evaluation, Drug discovery and development, Medicinal products, Pharmaceutics, Pharmacognosy and phytochemistry, Pharmacology, Pharmacotherapy, Toxicology and toxinology, Other pharmaceutical sciences
Affiliations
- Biocrystallography (Division)
Responsible
From1 Jan 2012 → Today - Biocrystallography (Division)
Member
From1 Dec 2005 → Today
Projects
1 - 10 of 40
- Activating negative regulators of KRAS signaling as a novel anticancer paradigmFrom1 Oct 2024 → TodayFunding: Fund Recuperation Fiscal Exemption, BOF - projects
- Elucidating the molecular architecture of intermediate filaments through chemical cross-linking and modellingFrom21 Aug 2024 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Design of targeted degraders of LEDGF/p75 with applications as anticancer agentsFrom25 Sep 2023 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Molecular structure and pharmacological activation of LZTR1 towards novel anticancer therapiesFrom5 Sep 2023 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Machine learning approaches to accelerate QM/MMFrom16 Aug 2023 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Type III intermediate filaments: molecular structure to understand muscular diseaseFrom1 Jan 2023 → TodayFunding: FWO research project (including WEAVE projects)
- When size matters: a platform to study molecular interactions and multimerisationFrom1 May 2022 → TodayFunding: FWO Medium Size Research Infrastructure
- Structure-based design of inhibitors targeting the chromatin-reading function of LEDGF/p75 to treat acute mixed-lineage leukemiaFrom1 Jan 2022 → TodayFunding: FWO research project (including WEAVE projects)
- Rational discovery of drug compounds targeting the chromatin-reading function of LEDGF/p75 towards the treatment for acute MLL-rearranged leukemiaFrom10 Sep 2021 → TodayFunding: FWO Strategic Basic Research Grant
- A 200 kV transmission electron microscope for high-resolution determination of 3D-ultrastructure of native proteins, cells and tissueFrom1 May 2020 → 30 Apr 2024Funding: FWO Medium Size Research Infrastructure
Publications
1 - 10 of 99
- Development of new antimicrobials: Rational design of polyomavirus and mycobacterial inhibitors(2023)
Authors: Stijn Lenders, Peter Verwilst, Sergei Strelkov, Arthur Van Aerschot
- Molecular structure of soluble vimentin tetramers(2023)
Authors: Pieter-Jan Vermeire, Jeremy Harvey, Sergei Strelkov
- Novel Insights Into Intermediate Filament Assembly Through Chemical Cross-Linking(2023)
Authors: Pieter-Jan Vermeire, Sergei Strelkov
- 5-(Perylen-3-ylethynyl)uracil as an antiviral scaffold: Potent suppression of enveloped virus reproduction by 3-methyl derivatives in vitro(2023)
Authors: Sergei Strelkov
- Stability profile of vimentin rod domain(2022)
Authors: Simon Leekens, Pieter-Jan Vermeire, Jeremy Harvey, Sergei Strelkov
- Structural Basis of Cysteine Ligase MshC Inhibition by Cysteinyl-Sulfonamides(2022)
Authors: Stijn Lenders, Evgenii Osipov, Jef Rozenski, Sergei Strelkov, Arthur Van Aerschot
- Partitioning of the initial catalytic steps of leucyl-tRNA synthetase is driven by an active site peptide-plane flip(2022)
Authors: Sergei Strelkov, Arthur Van Aerschot
- Discovery of novel druggable pockets on polyomavirus VP1 through crystallographic fragment-based screening to develop capsid assembly inhibitors(2022)
Authors: Evgenii Osipov, Arthur Van Aerschot, Sergei Strelkov
- Integrative Structural Biology Approach to Intermediate Filaments(2022)
Authors: Anastasia Lilina, Sergei Strelkov
- Molecular Interactions Driving Intermediate Filament Assembly(2021)
Authors: Pieter-Jan Vermeire, Giel Stalmans, Anastasia Lilina, Sergei Strelkov