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Researcher
Peter de Witte
- Disciplines:Biomarker discovery and evaluation, Drug discovery and development, Medicinal products, Pharmaceutics, Pharmacognosy and phytochemistry, Pharmacology, Pharmacotherapy, Toxicology and toxinology, Other pharmaceutical sciences
Affiliations
- Molecular Biodiscovery (Division)
Responsible
From1 Apr 2013 → Today - Molecular Biodiscovery (Division)
Member
From1 Apr 2013 → Today
Projects
1 - 10 of 30
- PHGDH-ASM: Phosphoglycerate dehydrogenase (PHGDH) activators as novel antiseizure medications (ASM) with dual mode of actionFrom1 Oct 2022 → TodayFunding: IOF - technology validation in lab
- Excitation-inhibition imbalance in autism-epilepsy comorbidity, a preclinical and clinical studyFrom1 Oct 2021 → 30 Sep 2023Funding: BOF - projects
- Development of innovative multi-dimensional liquid chromatography methods for the analysis of organic micropollutants and their degradation products in environmental waterFrom1 Sep 2021 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Multi-dimensional liquid chromatography for the analysis of complex samples.From1 Jan 2021 → 31 Dec 2022Funding: BOF - scientific equipment program
- SmartDetox - Removal of organic micropollutants from waterFrom1 Oct 2020 → TodayFunding: FWO Strategic Basic Research (SBO)
- Unraveling the in vivo host cell tropism and virus dissemination strategies of human norovirus.From28 Sep 2020 → TodayFunding: FWO fellowships
- A Lattice Light Sheet microscope to image subcellular molecular dynamics, cellular forces, neuroimmune interactions and neuronal activity in 3DFrom1 May 2020 → TodayFunding: FWO Medium Size Research Infrastructure
- Toxicity assessment of degradation products using zebrafish and advanced LC-MS techniquesFrom6 Jan 2020 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- An antisense strategy and network pharmacology approach in zebrafish models to identify novel targets for pharmacoresistant epilepsyFrom1 Nov 2019 → TodayFunding: FWO Strategic Basic Research Grant
- Zebrafish platform for neuroactive drug discovery and safety assessmentFrom1 Jan 2019 → 31 Dec 2020Funding: IOF - technology validation in lab
Publications
1 - 10 of 138
- New Phocoenamicin and Maklamicin Analogues from Cultures of Three Marine-Derived Micromonospora Strains.(2023)
Authors: Peter de Witte
Pages: 443 - The Role of Histo-Blood Group Antigens and Microbiota in Human Norovirus Replication in Zebrafish Larvae(2022)
Authors: Arno Cuvry, Dufie Strubbe, Johan Neyts, Peter de Witte, Joana Duarte Da Rocha Pereira
- Modulation of sleep behavior in zebrafish larvae by pharmacological targeting of the orexin receptor(2022)
Authors: Aleksandra Siekierska, Peter de Witte, Daniëlle Copmans
- Hyperactivation of mTORC1 in a double hit mutant zebrafish model of tuberous sclerosis complex causes increased seizure susceptibility and neurodevelopmental abnormalities(2022)
Authors: Ann-Sofie De Meulemeester, Lise Heylen, Aleksandra Siekierska, Peter de Witte
- Modeling mTORopathies in zebrafish(2022)
Authors: Ann-Sofie De Meulemeester, Peter de Witte, Lieven Lagae
- Pyruvate and uridine rescue the metabolic profile of OXPHOS dysfunction(2022)
Authors: Isabelle Adant, Bram Decru, Peter de Witte, Daisy Rymen, Peter Witters, Pieter Vermeersch, David Cassiman
- Development of compounds for the treatment of drug-resistant epilepsies(2022)
Authors: Gert Steurs, Wim De Borggraeve, Peter de Witte
- Connectivity Mapping Using a Novel sv2a Loss-of-Function Zebrafish Epilepsy Model as a Powerful Strategy for Anti-epileptic Drug Discovery(2022)
Authors: Lise Heylen, Michèle Partoens, Peter de Witte, Aleksandra Siekierska
- Antiseizure activity by opioid receptor antagonism, new evidence(2022)
Authors: Peter de Witte
Pages: 229 - 230 - From the North Sea to Drug Repurposing, the Antiseizure Activity of Halimide and Plinabulin.(2022)
Authors: Daniëlle Copmans, Emma Roux, Michèle Partoens, Gert Steurs, Wim De Borggraeve, Peter de Witte
Patents
1 - 10 of 10
- Treatment of epilepsy (Inventor)
- Treatment of epilepsy with plinabulin or halimide or diketopiperazine derivatives (Inventor)
- Treatment of epilepsy (Inventor)
- Treatment of epilepsy with plinabulin or halimide or diketopiperazine derivatives (Inventor)
- Treatment of epilepsy (Inventor)
- Anticonvulsant activity of turmeric oil and bisabolene sesquiterpenoids (Inventor)
- Anticonvulsant activity of bisabolene sesquiterpenoids isolated from turmeric oil (Inventor)
- Treatment of epilepsy (Inventor)
- TARGETED RADIOTHERAPY (Inventor)
- DAN SHEN EXTRACTS AND COMPOUNDS (Inventor)