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Researcher
Piet Herdewyn
- Disciplines:Biomarker discovery and evaluation, Drug discovery and development, Medicinal products, Pharmaceutics, Pharmacognosy and phytochemistry, Pharmacology, Pharmacotherapy, Toxicology and toxinology, Other pharmaceutical sciences, Bioinformatics and computational biology
Affiliations
- Medicinal Chemistry (Rega Institute) (Division)
Member
From1 Oct 1999 → Today
Projects
1 - 10 of 51
- Structure-based design of HBV polymerase inhibitorsFrom13 Sep 2021 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Synthetic Biology of mRNAFrom1 Mar 2021 → TodayFunding: H2020-EU.1.2.- EXCELLENT SCIENCE - Future and Emerging Technologies (FET)
- Artificial genetic systems with stereocontrolled sugar-phosphate backbone: towards advanced therapy and synthetic biology.From1 Jan 2021 → TodayFunding: FWO research project (including WEAVE projects)
- Selection of nucleic acids aptamers with four non-canonical bases for biomedical applicationsFrom1 Jan 2020 → 31 Dec 2020Funding: FWO research grant KAN
- New genetic systems with four synthetic nucleobases: towards advance therapy and synthetic biologyFrom1 Oct 2018 → 15 Dec 2021Funding: FWO fellowships
- Synthesis and structure determination of phosphonate oligonucleotidesFrom17 Sep 2018 → 17 Sep 2022Funding: Own budget, for example: patrimony, inscription fees, gifts
- Xylo- and lyxo-type phosphonate nucleic acids: Synthesis and structural analysisFrom17 Sep 2018 → 17 Sep 2022Funding: Own budget, for example: patrimony, inscription fees, gifts
- IN SEARCH FOR SUGAR, BASE OR PHOSPHATE MODIFIED NUCLEOSIDES ACTIVE AGAINST RNA VIRUSESFrom30 Nov 2017 → 7 Mar 2022Funding: Own budget, for example: patrimony, inscription fees, gifts
- GENERATION OF ARTIFICIAL NUCLEIC ACID SYSTEMS FOR BIOTECHNOLOGY AND THERAPEUTICSFrom1 Oct 2017 → 17 Jun 2022Funding: Own budget, for example: patrimony, inscription fees, gifts
- The establishment of a preclinical package for antiviral nucleoside phosphonate prodrugsFrom1 Oct 2017 → 30 Sep 2019Funding: IOF - Industrial Research Fund
Publications
21 - 30 of 344
- CRISPR-Cas9 recognition of enzymatically synthesized base-modified nucleic acids(2023)
Authors: Hui Yang, Mikhail Abramov, Maarten Jacquemyn, Elisabetta Groaz, Dirk Daelemans, Piet Herdewyn
Pages: 1501 - 1511 - Identification of Polyphenol Derivatives as Novel SARS-CoV-2 and DENV Non-Nucleoside RdRp Inhibitors(2023)
Authors: Hongtao Xu, Merel Oeyen, Steven De Jonghe, Dirk Jochmans, Johan Neyts, Piet Herdewyn, Dominique Schols
- A two-residue nascent-strand steric gate controls synthesis of 2′-O-methyl- and 2′-O-(2-methoxyethyl)-RNA(2023)
Authors: Mikhail Abramov, Piet Herdewyn
Pages: 91 - + - O-2-Alkylated Cytosine Acyclic Nucleoside Phosphonamidate Prodrugs Display Pan-Genotype Antiviral Activity against African Swine Fever Virus(2022)
Authors: Elisabetta Groaz, Piet Herdewyn
- Amino-acyl tXNA as inhibitors or amino acid donors in peptide synthesis(2022)
Authors: Piet Herdewyn
Pages: 11415 - 11425 - Crystallographic analysis of engineered polymerases synthesizing phosphonomethylthreosyl nucleic acid(2022)
Authors: Piet Herdewyn
Pages: 9663 - 9674 - Cryo-EM structures of wild-type and E138K/M184I mutant HIV-1 RT/DNA complexed with inhibitors doravirine and rilpivirine(2022)
Authors: Abhi Singh, Dominique Schols, Piet Herdewyn, Christophe Pannecouque, Kalyan Das
- Reshaping an Acyclic Nucleoside Phosphonate into a Selective Anti-hepatitis B Virus Compound(2022)
Authors: Elisabetta Groaz, Piet Herdewyn
- In Vivo Assembly and Expression of DNA Containing Non-canonical Bases in the Yeast Saccharomyces cerevisiae(2022)
Authors: Mikhail Abramov, Jef Rozenski, Piet Herdewyn
- IN SEARCH FOR SUGAR, BASE OR PHOSPHATE MODIFIED NUCLEOSIDES ACTIVE AGAINST RNA VIRUSES(2022)
Authors: Zihua Zheng, Graciela Andrei, Elisabetta Groaz, Steven De Jonghe, Piet Herdewyn
Patents
1 - 10 of 10
- Novel 6-substituted 7-deazapurines and corresponding nucleosides as medicaments (Inventor)
- Novel 6-substituted 7-deazapurines and corresponding nucleosides as medicaments (Inventor)
- Prodrugs of nucleoside phosphonates (Inventor)
- Novel prodrugs of nucleoside phosphonates (Inventor)
- Prodrugs of fluorinated acyclic nucleoside phosphonates (Inventor)
- Autoimmune and inflammatory disorder therapy (Inventor)
- Antiviral activity of bicyclic heterocycles (Inventor)
- Antiviral compounds, a process for their preparation, and their use for treating viral infections (Inventor)
- Prodrugs of fluorinated acyclic nucleoside phosphonates (Inventor)
- Purine analogues and their use as immunosuppressive agents (Inventor)