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Researcher
Piet Herdewyn
- Disciplines:Biomarker discovery and evaluation, Drug discovery and development, Medicinal products, Pharmaceutics, Pharmacognosy and phytochemistry, Pharmacology, Pharmacotherapy, Toxicology and toxinology, Other pharmaceutical sciences, Bioinformatics and computational biology
Affiliations
- Medicinal Chemistry (Rega Institute) (Division)
Member
From1 Oct 1999 → Today
Projects
41 - 50 of 51
- Liquid chromatogram couples to a mass spectrometer for bioanalytical applications.From22 Jul 2010 → 22 Jan 2017Funding: Hercules - Small and Medium size research infrastructure
- Synthesis of pyrophosphate analogues with a phosphonate function.From1 Apr 2010 → 31 Dec 2010Funding: BOF - Bilateral scientific cooperation
- W&T-fellow KACHARE D.From7 Jan 2010 → 6 Apr 2011Funding: POD Federal Science Policy Office - General
- SYNAPTA: Encoded synthesis, replication and evolution of unnatural nucleic acid therapeutics.From1 Jan 2010 → 31 Dec 2014Funding: Other resources managed by FWO
- Nucleotides, nucleic acids and their analogues as tools or targets for inhibitor design.From1 Oct 2009 → 30 Sep 2014Funding: BOF - Concerted Research Project from 1994
- "Capturing the CAP4": a new class of diagnostics fro Trypanosomatidae infections.From1 Oct 2009 → 30 Sep 2012Funding: FWO fellowships
- Design and synthesis of new compound libraries targeting kinasesFrom1 Sep 2009 → 14 Nov 2013Funding: Baekeland
- Molecular modeling, synthesis and biological evaluation of human amino-acyltRNA synthetase inhibitors as immunosuppressive agents.From1 Jan 2009 → 31 Dec 2014Funding: FWO research project
- Synthesis and biological evaluation of inhibitors of the of UvrD helicaseMycobacterium tuberculosis.From1 Dec 2008 → 31 Jan 2013Funding: IWT personal funding - strategic basic research grants
- Crystallographic study of the interaction between a modified oligonucleotide and the Klentaq1 polymerase in a ternary complex with a nucleotide monophosphate.From1 Oct 2008 → 30 Sep 2009Funding: BOF - Other initiatives
Publications
1 - 10 of 339
- Exploring the synthetic approaches and clinical prowess of established macrocyclic pharmaceuticals(2024)
Authors: Peng Nie, Piet Herdewyn
- Unlocking the synthetic approaches and clinical application of approved small-molecule drugs for gastrointestinal cancer treatment: A comprehensive exploration(2023)
Authors: Peng Nie, Piet Herdewyn
- Design, synthesis, and anti-respiratory syncytial virus potential of novel 3-(1,2,3-triazol-1-yl)furoxazine-fused benzimidazole derivatives(2023)
Authors: Piet Herdewyn
- Synthesis and clinical application of small-molecule inhibitors of Janus kinase(2023)
Authors: Peng Nie, Piet Herdewyn
- Synthetic approaches and application of clinically approved small-molecule Anti-HIV drugs: An update(2023)
Authors: Piet Herdewyn
- Advances of clinically approved small-molecule drugs for the treatment of non-small cell lung cancer(2023)
Authors: Peng Nie, Piet Herdewyn
- Recent advance of clinically approved small-molecule drugs for the treatment of myeloid leukemia(2023)
Authors: Peng Nie, Piet Herdewyn
- Modulation of the tetrameric I-motif folding of C-rich Tetrahymena telomeric sequences by hexitol nucleic acid (HNA) modifications(2023)
Authors: Piet Herdewyn, Elisabetta Groaz
Pages: 112 - 122 - Synthesis of mizoribine prodrugs and their in vivo evaluation as immunosuppressive agents(2023)
Authors: Ling-Jie Gao, Steven De Jonghe, Mark Waer, Piet Herdewyn
- A microbiological system for screening the interference of XNA monomers with DNA and RNA metabolism(2023)
Authors: Mikhail Abramov, Piet Herdewyn
Pages: 29862 - 29865
Patents
1 - 10 of 10
- Novel 6-substituted 7-deazapurines and corresponding nucleosides as medicaments (Inventor)
- Novel 6-substituted 7-deazapurines and corresponding nucleosides as medicaments (Inventor)
- Prodrugs of nucleoside phosphonates (Inventor)
- Novel prodrugs of nucleoside phosphonates (Inventor)
- Prodrugs of fluorinated acyclic nucleoside phosphonates (Inventor)
- Autoimmune and inflammatory disorder therapy (Inventor)
- Antiviral activity of bicyclic heterocycles (Inventor)
- Antiviral compounds, a process for their preparation, and their use for treating viral infections (Inventor)
- Prodrugs of fluorinated acyclic nucleoside phosphonates (Inventor)
- Purine analogues and their use as immunosuppressive agents (Inventor)