< Back to previous page
Researcher
Piet Herdewyn
- Disciplines:Biomarker discovery and evaluation, Drug discovery and development, Medicinal products, Pharmaceutics, Pharmacognosy and phytochemistry, Pharmacology, Pharmacotherapy, Toxicology and toxinology, Other pharmaceutical sciences, Bioinformatics and computational biology
Affiliations
- Medicinal Chemistry (Rega Institute) (Division)
Member
From1 Oct 1999 → Today
Projects
1 - 10 of 51
- Structure-based design of HBV polymerase inhibitorsFrom13 Sep 2021 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Synthetic Biology of mRNAFrom1 Mar 2021 → TodayFunding: H2020-EU.1.2.- EXCELLENT SCIENCE - Future and Emerging Technologies (FET)
- Artificial genetic systems with stereocontrolled sugar-phosphate backbone: towards advanced therapy and synthetic biology.From1 Jan 2021 → TodayFunding: FWO research project (including WEAVE projects)
- Selection of nucleic acids aptamers with four non-canonical bases for biomedical applicationsFrom1 Jan 2020 → 31 Dec 2020Funding: FWO research grant KAN
- New genetic systems with four synthetic nucleobases: towards advance therapy and synthetic biologyFrom1 Oct 2018 → 15 Dec 2021Funding: FWO fellowships
- Synthesis and structure determination of phosphonate oligonucleotidesFrom17 Sep 2018 → 17 Sep 2022Funding: Own budget, for example: patrimony, inscription fees, gifts
- Xylo- and lyxo-type phosphonate nucleic acids: Synthesis and structural analysisFrom17 Sep 2018 → 17 Sep 2022Funding: Own budget, for example: patrimony, inscription fees, gifts
- IN SEARCH FOR SUGAR, BASE OR PHOSPHATE MODIFIED NUCLEOSIDES ACTIVE AGAINST RNA VIRUSESFrom30 Nov 2017 → 7 Mar 2022Funding: Own budget, for example: patrimony, inscription fees, gifts
- GENERATION OF ARTIFICIAL NUCLEIC ACID SYSTEMS FOR BIOTECHNOLOGY AND THERAPEUTICSFrom1 Oct 2017 → 17 Jun 2022Funding: Own budget, for example: patrimony, inscription fees, gifts
- The establishment of a preclinical package for antiviral nucleoside phosphonate prodrugsFrom1 Oct 2017 → 30 Sep 2019Funding: IOF - Industrial Research Fund
Publications
31 - 40 of 344
- An Overview of Marketed Nucleoside and Nucleotide Analogs.(2022)
Authors: Steven De Jonghe, Piet Herdewyn
Pages: e376 - Exploring the dNTP -binding site of HIV-1 reverse transcriptase for inhibitor design(2021)
Authors: Weijie Gu, Sergio Martinez, Abhi Singh, Jef Rozenski, Dominique Schols, Piet Herdewyn, Kalyan Das, Steven De Jonghe
- Synthesis and in vitro antitumour activity of 4(R)-methyl-3-O-phosphonomethyl-α-L-threose nucleosides(2021)
Authors: Piet Herdewyn
- Structure-based design and synthesis of nucleoside-triphosphate analogs as new classes of viral polymerase inhibitors(2021)
Authors: Weijie Gu, Kalyan Das, Piet Herdewyn, Steven De Jonghe
- SYNTHESIS OF NEW TYPES OF CHLORINE-CONTAINING NUCLEOSIDES AND 2',6-DISUBSTITUTED URIDINES FOR ANTIVIRAL/ANTICANCER SCREENING(2021)
Authors: Fabio Da Paixao Soares, Piet Herdewyn, Elisabetta Groaz
- Functional Comparison of Laboratory-Evolved XNA Polymerases for Synthetic Biology(2021)
Authors: Piet Herdewyn
Pages: 1429 - 1437 - Introduction of a cyano group at the 2-position of an (R,S)-3-hydroxy-2-(phosphonomethoxy)propyl (HPMP) derivative of thymine elicits selective anti-HBV activity(2021)
Authors: Shuai Tan, Elisabetta Groaz, Piet Herdewyn
Pages: 804 - 808 - Noncanonical DNA polymerization by aminoadenine-based siphoviruses(2021)
Authors: Jef Rozenski, Piet Herdewyn
Pages: 520 - + - Discovery of 3-phenyl- and 3-N-piperidinyl-isothiazolo[4,3-b] pyridines as highly potent inhibitors of cyclin G-associated kinase(2021)
Authors: Mathy Froeyen, Dominique Schols, Piet Herdewyn, Steven De Jonghe
- Stable Hairpin Structures Formed by Xylose-Based Nucleic Acids(2021)
Authors: Charles-Alexandre Mattelaer, Piet Herdewyn, Eveline Lescrinier
Pages: 1638 - 1645
Patents
1 - 10 of 10
- Novel 6-substituted 7-deazapurines and corresponding nucleosides as medicaments (Inventor)
- Novel 6-substituted 7-deazapurines and corresponding nucleosides as medicaments (Inventor)
- Prodrugs of nucleoside phosphonates (Inventor)
- Novel prodrugs of nucleoside phosphonates (Inventor)
- Prodrugs of fluorinated acyclic nucleoside phosphonates (Inventor)
- Autoimmune and inflammatory disorder therapy (Inventor)
- Antiviral activity of bicyclic heterocycles (Inventor)
- Antiviral compounds, a process for their preparation, and their use for treating viral infections (Inventor)
- Prodrugs of fluorinated acyclic nucleoside phosphonates (Inventor)
- Purine analogues and their use as immunosuppressive agents (Inventor)