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Researcher
Piet Herdewyn
- Disciplines:Biomarker discovery and evaluation, Drug discovery and development, Medicinal products, Pharmaceutics, Pharmacognosy and phytochemistry, Pharmacology, Pharmacotherapy, Toxicology and toxinology, Other pharmaceutical sciences, Bioinformatics and computational biology
Affiliations
- Medicinal Chemistry (Rega Institute) (Division)
Member
From1 Oct 1999 → Today
Projects
1 - 10 of 51
- Structure-based design of HBV polymerase inhibitorsFrom13 Sep 2021 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Synthetic Biology of mRNAFrom1 Mar 2021 → TodayFunding: H2020-EU.1.2.- EXCELLENT SCIENCE - Future and Emerging Technologies (FET)
- Artificial genetic systems with stereocontrolled sugar-phosphate backbone: towards advanced therapy and synthetic biology.From1 Jan 2021 → TodayFunding: FWO research project (including WEAVE projects)
- Selection of nucleic acids aptamers with four non-canonical bases for biomedical applicationsFrom1 Jan 2020 → 31 Dec 2020Funding: FWO research grant KAN
- New genetic systems with four synthetic nucleobases: towards advance therapy and synthetic biologyFrom1 Oct 2018 → 15 Dec 2021Funding: FWO fellowships
- Synthesis and structure determination of phosphonate oligonucleotidesFrom17 Sep 2018 → 17 Sep 2022Funding: Own budget, for example: patrimony, inscription fees, gifts
- Xylo- and lyxo-type phosphonate nucleic acids: Synthesis and structural analysisFrom17 Sep 2018 → 17 Sep 2022Funding: Own budget, for example: patrimony, inscription fees, gifts
- IN SEARCH FOR SUGAR, BASE OR PHOSPHATE MODIFIED NUCLEOSIDES ACTIVE AGAINST RNA VIRUSESFrom30 Nov 2017 → 7 Mar 2022Funding: Own budget, for example: patrimony, inscription fees, gifts
- GENERATION OF ARTIFICIAL NUCLEIC ACID SYSTEMS FOR BIOTECHNOLOGY AND THERAPEUTICSFrom1 Oct 2017 → 17 Jun 2022Funding: Own budget, for example: patrimony, inscription fees, gifts
- The establishment of a preclinical package for antiviral nucleoside phosphonate prodrugsFrom1 Oct 2017 → 30 Sep 2019Funding: IOF - Industrial Research Fund
Publications
41 - 50 of 344
- The Network of Replication, Transcription, and Reverse Transcription of a Synthetic Genetic Cassette(2021)
Authors: Hui Yang, Elena Eremeeva, Mikhail Abramov, Piet Herdewyn
Pages: 4175 - 4182 - Influence of 4′-Substitution on the Activity of Gemcitabine and Its ProTide Against VZV and SARS-CoV-2(2021)
Authors: Zihua Zheng, Elisabetta Groaz, Robert Snoeck, Steven De Jonghe, Piet Herdewyn, Graciela Andrei
Pages: 88 - 92 - Anno 2021: Which antivirals for the coming decade?(2021)
Authors: Elisabetta Groaz, Erik De Clercq, Piet Herdewyn
Pages: 49 - 107 - Tenofovir-Amino Acid Conjugates Act as Polymerase Substrates—Implications for Avoiding Cellular Phosphorylation in the Discovery of Nucleotide Analogues(2020)
Authors: Weijie Gu, Sergio Martinez, Hongtao Xu, Piet Herdewyn, Steven De Jonghe, Kalyan Das
Pages: 782 - 796 - Structural Studies of HNA Substrate Specificity in Mutants of an Archaeal DNA Polymerase Obtained by Directed Evolution(2020)
Authors: Jef Rozenski, Mikhail Abramov, Vitor Bernardes Pinheiro, Piet Herdewyn
- Scalable Synthesis, In Vitro cccDNA Reduction, and In Vivo Antihepatitis B Virus Activity of a Phosphonomethoxydeoxythreosyl Adenine Prodrug(2020)
Authors: Elisabetta Groaz, Steven De Jonghe, Piet Herdewyn
Pages: 13851 - 13860 - Enzymatic Formation of an Artificial Base Pair Using a Modified Purine Nucleoside Triphosphate(2020)
Authors: Piet Herdewyn
Pages: 2872 - 2884 - Synthesis and Antiviral Evaluation of 3'-C-Hydroxymethyl-3'-O-Phosphonomethyl-β-D-5'-deoxyxylose Nucleosides(2020)
Authors: Piet Herdewyn
Pages: 4995 - 5002 - Synthesis and Antitumor Activity of C-7-Alkynylated and Arylated Pyrrolotriazine C-Ribonucleosides(2020)
Authors: Elisabetta Groaz, Dirk Daelemans, Piet Herdewyn
Pages: 1605 - 1610 - Structure-Activity Relationship Study of a Potent α-Thrombin Binding Aptamer Incorporating Hexitol Nucleotides(2020)
Authors: Elena Eremeeva, Hui Yang, Piet Herdewyn
Pages: 9589 - 9597
Patents
1 - 10 of 10
- Novel 6-substituted 7-deazapurines and corresponding nucleosides as medicaments (Inventor)
- Novel 6-substituted 7-deazapurines and corresponding nucleosides as medicaments (Inventor)
- Prodrugs of nucleoside phosphonates (Inventor)
- Novel prodrugs of nucleoside phosphonates (Inventor)
- Prodrugs of fluorinated acyclic nucleoside phosphonates (Inventor)
- Autoimmune and inflammatory disorder therapy (Inventor)
- Antiviral activity of bicyclic heterocycles (Inventor)
- Antiviral compounds, a process for their preparation, and their use for treating viral infections (Inventor)
- Prodrugs of fluorinated acyclic nucleoside phosphonates (Inventor)
- Purine analogues and their use as immunosuppressive agents (Inventor)