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Researcher
Piet Herdewyn
- Disciplines:Biomarker discovery and evaluation, Drug discovery and development, Medicinal products, Pharmaceutics, Pharmacognosy and phytochemistry, Pharmacology, Pharmacotherapy, Toxicology and toxinology, Other pharmaceutical sciences, Bioinformatics and computational biology
Affiliations
- Medicinal Chemistry (Rega Institute) (Division)
Member
From1 Oct 1999 → Today
Projects
1 - 10 of 51
- Structure-based design of HBV polymerase inhibitorsFrom13 Sep 2021 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Synthetic Biology of mRNAFrom1 Mar 2021 → TodayFunding: H2020-EU.1.2.- EXCELLENT SCIENCE - Future and Emerging Technologies (FET)
- Artificial genetic systems with stereocontrolled sugar-phosphate backbone: towards advanced therapy and synthetic biology.From1 Jan 2021 → TodayFunding: FWO research project (including WEAVE projects)
- Selection of nucleic acids aptamers with four non-canonical bases for biomedical applicationsFrom1 Jan 2020 → 31 Dec 2020Funding: FWO research grant KAN
- New genetic systems with four synthetic nucleobases: towards advance therapy and synthetic biologyFrom1 Oct 2018 → 15 Dec 2021Funding: FWO fellowships
- Synthesis and structure determination of phosphonate oligonucleotidesFrom17 Sep 2018 → 17 Sep 2022Funding: Own budget, for example: patrimony, inscription fees, gifts
- Xylo- and lyxo-type phosphonate nucleic acids: Synthesis and structural analysisFrom17 Sep 2018 → 17 Sep 2022Funding: Own budget, for example: patrimony, inscription fees, gifts
- IN SEARCH FOR SUGAR, BASE OR PHOSPHATE MODIFIED NUCLEOSIDES ACTIVE AGAINST RNA VIRUSESFrom30 Nov 2017 → 7 Mar 2022Funding: Own budget, for example: patrimony, inscription fees, gifts
- GENERATION OF ARTIFICIAL NUCLEIC ACID SYSTEMS FOR BIOTECHNOLOGY AND THERAPEUTICSFrom1 Oct 2017 → 17 Jun 2022Funding: Own budget, for example: patrimony, inscription fees, gifts
- The establishment of a preclinical package for antiviral nucleoside phosphonate prodrugsFrom1 Oct 2017 → 30 Sep 2019Funding: IOF - Industrial Research Fund
Publications
11 - 20 of 344
- Modulation of the tetrameric I-motif folding of C-rich Tetrahymena telomeric sequences by hexitol nucleic acid (HNA) modifications(2023)
Authors: Piet Herdewyn, Elisabetta Groaz
Pages: 112 - 122 - Synthesis of mizoribine prodrugs and their in vivo evaluation as immunosuppressive agents(2023)
Authors: Ling-Jie Gao, Steven De Jonghe, Mark Waer, Piet Herdewyn
- A microbiological system for screening the interference of XNA monomers with DNA and RNA metabolism(2023)
Authors: Mikhail Abramov, Piet Herdewyn
Pages: 29862 - 29865 - Conformational Morphing by a DNA Analogue Featuring 7-Deazapurines and 5-Halogenpyrimidines and the Origins of Adenine-Tract Geometry(2023)
Authors: Mikhail Abramov, Piet Herdewyn
Pages: 2854 - 2867 - Synthesis of Novel 2,2'-Anhydro-L-threosylpyrimidine Phosphonates(2023)
Authors: Piet Herdewyn
Pages: 3167 - 3173 - Characterization of an HNA aptamer suggests a non-canonical G-quadruplex motif(2023)
Authors: Jérôme Rihon, Charles-Alexandre Mattelaer, Piet Herdewyn, Eveline Lescrinier
Pages: 7736 - 7748 - Synthesis and anticancer evaluation of acetylated-lysine conjugated gemcitabine prodrugs(2023)
Authors: Piet Herdewyn
Pages: 1572 - 1580 - Controlled E. coli Aggregation Mediated by DNA and XNA Hybridization(2023)
Authors: Piet Herdewyn
- Synthesis, antiviral activity, and computational study of β-D-xylofuranosyl nucleoside phosphonates(2023)
Authors: Yuqing Xu, Elisabetta Groaz, Jérôme Rihon, Piet Herdewyn, Eveline Lescrinier
- Synthesis and anti-SARS-CoV-2 evaluation of lipid prodrugs of ?-D-N4-hydroxycytidine (NHC) and a 3?-fluoro-substituted analogue of NHC(2023)
Authors: Piet Herdewyn, Robert Snoeck, Graciela Andrei
Patents
1 - 10 of 10
- Novel 6-substituted 7-deazapurines and corresponding nucleosides as medicaments (Inventor)
- Novel 6-substituted 7-deazapurines and corresponding nucleosides as medicaments (Inventor)
- Prodrugs of nucleoside phosphonates (Inventor)
- Novel prodrugs of nucleoside phosphonates (Inventor)
- Prodrugs of fluorinated acyclic nucleoside phosphonates (Inventor)
- Autoimmune and inflammatory disorder therapy (Inventor)
- Antiviral activity of bicyclic heterocycles (Inventor)
- Antiviral compounds, a process for their preparation, and their use for treating viral infections (Inventor)
- Prodrugs of fluorinated acyclic nucleoside phosphonates (Inventor)
- Purine analogues and their use as immunosuppressive agents (Inventor)