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Researcher
Piet Herdewyn
- Disciplines:Biomarker discovery and evaluation, Drug discovery and development, Medicinal products, Pharmaceutics, Pharmacognosy and phytochemistry, Pharmacology, Pharmacotherapy, Toxicology and toxinology, Other pharmaceutical sciences, Bioinformatics and computational biology
Affiliations
- Medicinal Chemistry (Rega Institute) (Division)
Member
From1 Oct 1999 → Today
Projects
21 - 30 of 51
- SYNTHESIS OF NEW TYPES OF CHLORINE-CONTAINING NUCLEOSIDES AND 2',6-DISUBSTITUTED URIDINES FOR ANTIVIRAL/ANTICANCER SCREENINGFrom15 Jun 2014 → 7 Sep 2021Funding: Own budget, for example: patrimony, inscription fees, gifts
- Selection of nucleic acid chemistry for therapeutic aptamer design.From1 Jan 2014 → 31 Dec 2017Funding: FWO research project
- EAG1 as a target for the diagnosis and therapy in childhood tumors: in appearance and late effects.From1 Jan 2014 → 31 Dec 2017Funding: FWO research project
- Synthesis, conformational study and biological evaluation of pentopyranoside nucleoside phosphonatesFrom1 Oct 2013 → 7 Jun 2019Funding: Own budget, for example: patrimony, inscription fees, gifts
- Metabole Aptazymes: isolating of binders / catalystsFrom1 Oct 2013 → 1 Feb 2019Funding: FWO fellowships
- Evolve HNA aptamers by Cell-SELEX as molecular tools for cancer study.From1 Oct 2013 → 30 Sep 2017Funding: FWO fellowships
- Acyclic Phosphono Nucleosides, Nucleotides, and Oligonucleotides: Synthesis, Antiviral Evaluation, and Genetic SelectionFrom1 Sep 2013 → 31 Oct 2021Funding: SCK (Study Centre Nuclear Energy)
- Development of an artificial information systemFrom1 Apr 2013 → 31 Mar 2018Funding: ERC - Ideas
- Structural and biological evaluation of Xylonucleic acids (XNA) as a potential tool for synthetic biology/oligonucleotide based therapeutic application.From1 Oct 2012 → 30 Sep 2015Funding: FWO fellowships
- Redesigning the leaving group in self-replicating systems.From1 Oct 2012 → 30 Sep 2016Funding: FWO fellowships
Publications
1 - 10 of 344
- Exploring the synthetic approaches and clinical prowess of established macrocyclic pharmaceuticals(2024)
Authors: Peng Nie, Piet Herdewyn
- Neddylation-dependent LSD1 destabilization inhibits the stemness and chemoresistance of gastric cancer(2024)
Authors: Piet Herdewyn
- Degraders in epigenetic therapy: PROTACs and beyond.(2024)
Authors: Piet Herdewyn
Pages: 1464 - 1499 - Synthetic approaches and application of clinically approved small-molecule drugs to treat hepatitis(2023)
Authors: Piet Herdewyn
- Unlocking the synthetic approaches and clinical application of approved small-molecule drugs for gastrointestinal cancer treatment: A comprehensive exploration(2023)
Authors: Peng Nie, Piet Herdewyn
- Design, synthesis, and anti-respiratory syncytial virus potential of novel 3-(1,2,3-triazol-1-yl)furoxazine-fused benzimidazole derivatives(2023)
Authors: Piet Herdewyn
- Synthesis and clinical application of small-molecule inhibitors of Janus kinase(2023)
Authors: Peng Nie, Piet Herdewyn
- Synthetic approaches and application of clinically approved small-molecule Anti-HIV drugs: An update(2023)
Authors: Piet Herdewyn
- Advances of clinically approved small-molecule drugs for the treatment of non-small cell lung cancer(2023)
Authors: Peng Nie, Piet Herdewyn
- Recent advance of clinically approved small-molecule drugs for the treatment of myeloid leukemia(2023)
Authors: Peng Nie, Piet Herdewyn
Patents
1 - 10 of 10
- Novel 6-substituted 7-deazapurines and corresponding nucleosides as medicaments (Inventor)
- Novel 6-substituted 7-deazapurines and corresponding nucleosides as medicaments (Inventor)
- Prodrugs of nucleoside phosphonates (Inventor)
- Novel prodrugs of nucleoside phosphonates (Inventor)
- Prodrugs of fluorinated acyclic nucleoside phosphonates (Inventor)
- Autoimmune and inflammatory disorder therapy (Inventor)
- Antiviral activity of bicyclic heterocycles (Inventor)
- Antiviral compounds, a process for their preparation, and their use for treating viral infections (Inventor)
- Prodrugs of fluorinated acyclic nucleoside phosphonates (Inventor)
- Purine analogues and their use as immunosuppressive agents (Inventor)