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Researcher
Bart De Strooper
- Disciplines (Flanders Institute for Biotechnology):Analysis of next-generation sequence data, Cell death, Behavioural neuroscience
- Disciplines (KU Leuven):Neurosciences, Biological and physiological psychology, Cognitive science and intelligent systems, Developmental psychology and ageing
- See also: Bart De Strooper (Flanders Institute for Biotechnology)
Affiliations
- Laboratory for the Research of Neurodegenerative Diseases (VIB-KU Leuven) (Lab)
Responsible
From1 Jan 2006 → Today - Laboratory for the Research of Neurodegenerative Diseases (VIB-KU Leuven) (Lab)
Member
From1 Jan 2017 → Today - De Strooper Lab (Research group)
Responsible
From1 Jan 2017 → Today - Department of Human Genetics (Department)
Member
From1 Oct 1999 → 31 Dec 2016
Projects
1 - 10 of 80
- MEG3 activates necroptosis in human neuron xenografts modeling Alzheimer's diseaseFrom16 May 2024 → TodayFunding: Foundations, funds and other with scientific goal
- Spatial Proteomics to Investigate the Cellular Phase of Alzheimer’s DiseaseFrom13 Feb 2023 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- A novel chimeric model investigating human neurological features in Alzheimer’s diseaseFrom1 Jan 2023 → TodayFunding: FWO fellowships
- A vicious Aβ oligomers-dependent neuron-microglia cycle fuels Alzheimer's DiseaseFrom1 Jan 2023 → TodayFunding: Other federal public and semi-governmental institutions
- Human-mouse neuronal xenografts to study incipient Alzheimer’s Disease.From1 Jan 2023 → TodayFunding: FWO research project (including WEAVE projects)
- The early microglia–neuron interactions in Alzheimer’s Disease and their modulation by immunotherapyFrom1 Jan 2023 → TodayFunding: FWO research project (including WEAVE projects)
- Restoring miR-132 expression rescues adult hippocampal neurogenesis and memory deficits in Alzheimer's diseaseFrom1 May 2022 → 31 Dec 2022Funding: Foundations, funds and other with scientific goal
- Therapeutic targeting of pathogenic presynaptic Tau in human neurons in a chimeric Alzheimer’s Disease mouse modelFrom24 Jan 2022 → TodayFunding: FWO Strategic Basic Research Grant
- Genetic Risk in Alzheimer's diseaseFrom14 Jan 2022 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Functional characterization of human neurons in the human-mouse chimeric model for Alzheimer’s diseaseFrom5 Oct 2021 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
Publications
11 - 20 of 330
- MEG3 activates necroptosis in human neuron xenografts modeling Alzheimer's disease(2023)
Authors: Sriram Balusu, Nicky Thrupp, Dries T'Syen, Annerieke Sierksma, Dietmar Thal, Mark Fiers, Bart De Strooper
Pages: 1176 - + - Intracerebral Hemorrhage Among Blood Donors and Their Transfusion Recipients(2023)
Authors: Bart De Strooper, Robin Lemmens
Pages: 941 - 950 - A fully automated home cage for long-term continuous phenotyping of mouse cognition and behavior(2023)
Authors: Bart De Strooper
- Functional and topological analysis of Pen-2, the fourth subunit of the γ-secretase complex (Withdrawal of Vol 286, art no 12271, 2011)(2023)
Authors: Lucia Chavez Gutierrez, An Zwijsen, Bart De Strooper
- microRNA-132 regulates gene expression programs involved in microglial homeostasis(2023)
Authors: Kristofer Davie, Nicky Thrupp, Mark Fiers, Bart De Strooper
- Selective inhibitors of the PSEN1-gamma-secretase complex.(2023)
Authors: Dries T'Syen, Maarten Dewilde, Bart De Strooper
Pages: 104794 - Novel Human/Non-Human Primate Cross-Reactive Anti-Transferrin Receptor Nanobodies for Brain Delivery of Biologics(2023)
Authors: Sam Noppen, Dominique Schols, Bart De Strooper, Maarten Dewilde
- Early alterations in the MCH system link aberrant neuronal activity and sleep disturbances in a mouse model of Alzheimer's disease(2023)
Authors: Nicky Thrupp, Mark Fiers, Joris de Wit, Kristofer Davie, Dietmar Thal, Bart De Strooper
Pages: 1021 - + - Apoptotic cell death in disease-Current understanding of the NCCD 2023(2023)
Authors: Patrizia Agostinis, Bart De Strooper, Abhishek Garg, Chris Marine
Pages: 1097 - 1154 - UNRAVELLING THE ROLE OF NEURONAL MAPT-AS1 ON THE REGULATION OF TAU EXPRESSION(2023)
Authors: Bart De Strooper, Annerieke Sierksma
Patents
1 - 10 of 10
- Γ-secretase stabilizing compound screening assay (Inventor)
- Gamma-secretase stabilizing compound screening assay (Inventor)
- Therapeutic agents for neurological and psychiatric disorders (Inventor)
- Therapeutic agents for neurological and psychiatric disorders (Inventor)
- Single domain antibodies capable of modulating bace activity (Inventor)
- Therapeutic agents for neurological and psychiatric disorders (Inventor)
- Single domain antibodies capable of modulating bace activity (Inventor)
- Gamma-secretase stabilizing compound screening assay (Inventor)
- Restoring phosphorylation of a novel pink1 substrate to treat parkinson's disease (Inventor)
- Restoring phosphorylation of a novel pink1 substrate to treat parkinson's disease (Inventor)