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Researcher
Bart De Strooper
- Disciplines (Flanders Institute for Biotechnology):Analysis of next-generation sequence data, Cell death, Behavioural neuroscience
- Disciplines (KU Leuven):Neurosciences, Biological and physiological psychology, Cognitive science and intelligent systems, Developmental psychology and ageing
- See also: Bart De Strooper (Flanders Institute for Biotechnology)
Affiliations
- Laboratory for the Research of Neurodegenerative Diseases (VIB-KU Leuven) (Lab)
Responsible
From1 Jan 2006 → Today - Laboratory for the Research of Neurodegenerative Diseases (VIB-KU Leuven) (Lab)
Member
From1 Jan 2017 → Today - De Strooper Lab (Research group)
Responsible
From1 Jan 2017 → Today - Department of Human Genetics (Department)
Member
From1 Oct 1999 → 31 Dec 2016
Projects
11 - 20 of 80
- Resilience and vulnerability in the cellular phase of Alzheimer’s disease.From1 Oct 2021 → TodayFunding: BOF - Methusalem
- Necroptosis pathway activation and its role in neuronal cell loss in Alzheimer's diseaseFrom1 Oct 2021 → TodayFunding: FWO senior postdoctoral fellowship
- The role of microglia in the pathogenesis of Alzheimer’s DiseaseFrom10 Sep 2021 → TodayFunding: FWO fellowships
- Understanding the cellular phase of Alzheimer’s disease using spatial transcriptomicsFrom1 Sep 2021 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Investigating the cellular phase of Alzheimer’s disease using spatial transcriptomics.From1 Jun 2021 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Pyroptotic cell death in Alzheimer’s disease: pathological relevance and functional in vitro analysis.From16 Dec 2020 → TodayFunding: BOF - doctoral mandates
- Spatially multiplexed RNA and protein detection to study Alzheimer’s disease.From1 Oct 2020 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Resolving Alzheimer’s Disease: the role of immunoresolvent lipids in the microglia response to amyloid plaquesFrom1 Oct 2020 → 30 Sep 2022Funding: FWO fellowships
- Atomic Force Microscopy Enhanced Spectroscopy to Study Strains and Seeding of Amyloids In SituFrom1 May 2020 → TodayFunding: FWO Medium Size Research Infrastructure
- The study of initial cellular phase of Alzheimer's disease.From1 Apr 2020 → 31 Dec 2020Funding: Foundations, funds and other with scientific goal
Publications
1 - 10 of 330
- Xenografted human microglia display diverse transcriptomic states in response to Alzheimer's disease-related amyloid-β pathology.(2024)
Authors: Catherine Verfaillie, Bart De Strooper
- The γ-secretase substrate proteome and its role in cell signaling regulation(2024)
Authors: Pengfei Hou, Bart De Strooper, Renzo Mancuso
- New precision medicine avenues to the prevention of Alzheimer's disease from insights into the structure and function of γ-secretases.(2024)
Authors: Bart De Strooper
Pages: 887 - 903 - A xenograft model to study human microglia genetics, development and disease(2024)
Authors: Nicola Fattorelli, Bart De Strooper, Renzo Mancuso
- Functional and topological analysis of PSENEN, the fourth subunit of the γ-secretase complex.(2024)
Authors: An Zwijsen, Lucia Chavez Gutierrez, Bart De Strooper
Pages: 105533 - Transcriptomics to study the cellular phase of Alzheimer's Disease(2023)
Authors: Nicky Thrupp, Bart De Strooper, Mark Fiers
- Untangling the role of APOE in astrocytes and microglia in Alzheimer's disease(2023)
Authors: Pranav Preman, Bart De Strooper, Amaia Arranz Mendiguren
- The y-secretase substrate proteome and its role in cell signaling regulation(2023)
Authors: Nicola Fattorelli, Dries T'Syen, Sriram Balusu, Tom Theys, Bart De Strooper, Mark Fiers
Pages: 4106 - + - Discovery of brain permeable 2-Azabicyclo[2.2.2]octane sulfonamides as a novel class of presenilin-1 selective γ-secretase inhibitors(2023)
Authors: Bart De Strooper
- INVESTIGATING EPIGENETIC REGULATION OF MICROGLIA IN A HUMAN-MOUSE CHIMERA MODEL OF ALZHEIMER'S DISEASE(2023)
Authors: Bart De Strooper
Pages: S90 - S91
Patents
1 - 10 of 10
- Γ-secretase stabilizing compound screening assay (Inventor)
- Gamma-secretase stabilizing compound screening assay (Inventor)
- Therapeutic agents for neurological and psychiatric disorders (Inventor)
- Therapeutic agents for neurological and psychiatric disorders (Inventor)
- Single domain antibodies capable of modulating bace activity (Inventor)
- Therapeutic agents for neurological and psychiatric disorders (Inventor)
- Single domain antibodies capable of modulating bace activity (Inventor)
- Gamma-secretase stabilizing compound screening assay (Inventor)
- Restoring phosphorylation of a novel pink1 substrate to treat parkinson's disease (Inventor)
- Restoring phosphorylation of a novel pink1 substrate to treat parkinson's disease (Inventor)