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Researcher
Bart De Strooper
- Disciplines (Flanders Institute for Biotechnology):Analysis of next-generation sequence data, Cell death, Behavioural neuroscience
- Disciplines (KU Leuven):Neurosciences, Biological and physiological psychology, Cognitive science and intelligent systems, Developmental psychology and ageing
- See also: Bart De Strooper (Flanders Institute for Biotechnology)
Affiliations
- Laboratory for the Research of Neurodegenerative Diseases (VIB-KU Leuven) (Lab)
Responsible
From1 Jan 2006 → Today - Laboratory for the Research of Neurodegenerative Diseases (VIB-KU Leuven) (Lab)
Member
From1 Jan 2017 → Today - De Strooper Lab (Research group)
Responsible
From1 Jan 2017 → Today - Department of Human Genetics (Department)
Member
From1 Oct 1999 → 31 Dec 2016
Projects
1 - 10 of 79
- Spatial Proteomics to Investigate the Cellular Phase of Alzheimer’s DiseaseFrom13 Feb 2023 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- A novel chimeric model investigating human neurological features in Alzheimer’s diseaseFrom1 Jan 2023 → TodayFunding: FWO fellowships
- A vicious Aβ oligomers-dependent neuron-microglia cycle fuels Alzheimer's DiseaseFrom1 Jan 2023 → TodayFunding: Other federal public and semi-governmental institutions
- Human-mouse neuronal xenografts to study incipient Alzheimer’s Disease.From1 Jan 2023 → TodayFunding: FWO research project (including WEAVE projects)
- The early microglia–neuron interactions in Alzheimer’s Disease and their modulation by immunotherapyFrom1 Jan 2023 → TodayFunding: FWO research project (including WEAVE projects)
- Restoring miR-132 expression rescues adult hippocampal neurogenesis and memory deficits in Alzheimer's diseaseFrom1 May 2022 → 31 Dec 2022Funding: Foundations, funds and other with scientific goal
- Therapeutic targeting of pathogenic presynaptic Tau in human neurons in a chimeric Alzheimer’s Disease mouse modelFrom24 Jan 2022 → TodayFunding: FWO Strategic Basic Research Grant
- Genetic Risk in Alzheimer's diseaseFrom14 Jan 2022 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Functional characterization of human neurons in the human-mouse chimeric model for Alzheimer’s diseaseFrom5 Oct 2021 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Resilience and vulnerability in the cellular phase of Alzheimer’s disease.From1 Oct 2021 → TodayFunding: BOF - Methusalem
Publications
1 - 10 of 329
- The γ-secretase substrate proteome and its role in cell signaling regulation(2024)
Authors: Pengfei Hou, Bart De Strooper, Renzo Mancuso
- New precision medicine avenues to the prevention of Alzheimer's disease from insights into the structure and function of γ-secretases.(2024)
Authors: Bart De Strooper
Pages: 887 - 903 - A xenograft model to study human microglia genetics, development and disease(2024)
Authors: Nicola Fattorelli, Bart De Strooper, Renzo Mancuso
- Functional and topological analysis of PSENEN, the fourth subunit of the γ-secretase complex.(2024)
Authors: An Zwijsen, Lucia Chavez Gutierrez, Bart De Strooper
Pages: 105533 - Transcriptomics to study the cellular phase of Alzheimer's Disease(2023)
Authors: Nicky Thrupp, Bart De Strooper, Mark Fiers
- Untangling the role of APOE in astrocytes and microglia in Alzheimer's disease(2023)
Authors: Pranav Preman, Bart De Strooper, Amaia Arranz Mendiguren
- The y-secretase substrate proteome and its role in cell signaling regulation(2023)
Authors: Nicola Fattorelli, Dries T'Syen, Sriram Balusu, Tom Theys, Bart De Strooper, Mark Fiers
Pages: 4106 - + - Discovery of brain permeable 2-Azabicyclo[2.2.2]octane sulfonamides as a novel class of presenilin-1 selective γ-secretase inhibitors(2023)
Authors: Bart De Strooper
- INVESTIGATING EPIGENETIC REGULATION OF MICROGLIA IN A HUMAN-MOUSE CHIMERA MODEL OF ALZHEIMER'S DISEASE(2023)
Authors: Bart De Strooper
Pages: S90 - S91 - MEG3 activates necroptosis in human neuron xenografts modeling Alzheimer's disease(2023)
Authors: Sriram Balusu, Nicky Thrupp, Dries T'Syen, Annerieke Sierksma, Dietmar Thal, Mark Fiers, Bart De Strooper
Pages: 1176 - +
Patents
1 - 10 of 10
- Γ-secretase stabilizing compound screening assay (Inventor)
- Gamma-secretase stabilizing compound screening assay (Inventor)
- Therapeutic agents for neurological and psychiatric disorders (Inventor)
- Therapeutic agents for neurological and psychiatric disorders (Inventor)
- Single domain antibodies capable of modulating bace activity (Inventor)
- Therapeutic agents for neurological and psychiatric disorders (Inventor)
- Single domain antibodies capable of modulating bace activity (Inventor)
- Gamma-secretase stabilizing compound screening assay (Inventor)
- Restoring phosphorylation of a novel pink1 substrate to treat parkinson's disease (Inventor)
- Restoring phosphorylation of a novel pink1 substrate to treat parkinson's disease (Inventor)