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Researcher
Bart De Strooper
- Disciplines (Flanders Institute for Biotechnology):Analysis of next-generation sequence data, Cell death, Behavioural neuroscience
- Disciplines (KU Leuven):Neurosciences, Biological and physiological psychology, Cognitive science and intelligent systems, Developmental psychology and ageing
- See also: Bart De Strooper (Flanders Institute for Biotechnology)
Affiliations
- Laboratory for the Research of Neurodegenerative Diseases (VIB-KU Leuven) (Lab)
Responsible
From1 Jan 2006 → Today - Laboratory for the Research of Neurodegenerative Diseases (VIB-KU Leuven) (Lab)
Member
From1 Jan 2017 → Today - De Strooper Lab (Research group)
Responsible
From1 Jan 2017 → Today - Department of Human Genetics (Department)
Member
From1 Oct 1999 → 31 Dec 2016
Projects
71 - 80 of 80
- Molecular correlation between Alzheimer disease and Fragile X syndrome.From1 Oct 2009 → 14 Oct 2014Funding: FWO fellowships
- Genetic identification of novel drug targets for tauopathies in D. Melanogaster.From1 Oct 2009 → 1 Oct 2013Funding: IWT personal funding - strategic basic research grants
- Antibody-based inhibition and functional studies of BACE1, the Beta-secretase in Alzheimer's diseaseFrom1 Dec 2008 → 27 Oct 2011Funding: Own budget, for example: patrimony, inscription fees, gifts
- Functional and structural characterisation of the gamma secretase complex.From1 Oct 2008 → 2 Jul 2013Funding: Own budget, for example: patrimony, inscription fees, gifts
- APLP2 regulates neuronal stem cell differentiation during cortical developmentFrom10 Sep 2008 → 12 Dec 2013Funding: Own budget, for example: patrimony, inscription fees, gifts
- Amyloid Precursor Proteins are neuronal specific modulators of Wnt PCP signaling.From2 Jun 2008 → 26 Nov 2012Funding: Own budget, for example: patrimony, inscription fees, gifts
- Identification and characterisation of the cell surface receptor(s) of sAPPalphaFrom1 Jan 2008 → 31 Dec 2008Funding: Own budget, for example: patrimony, inscription fees, gifts
- Analysis of mitochondrial dysfunction in Parkinson disease.From1 Jan 2008 → 31 Dec 2011Funding: FWO research project (including WEAVE projects)
- General cognitive ability, hippocampal metaplasticity, and detection of neurocognitive impairment in murine models of Alzheimer's disease.From1 Jan 2008 → 31 Dec 2013Funding: FWO research project (including WEAVE projects)
- Resilience and vulnerability in the cellular phase of Alzheimer’s disease.From1 Oct 2000 → TodayFunding: BOF - ZAP BOF mandates
Publications
1 - 10 of 330
- Xenografted human microglia display diverse transcriptomic states in response to Alzheimer's disease-related amyloid-β pathology.(2024)
Authors: Sriram Balusu, Catherine Verfaillie, Bart De Strooper
- The γ-secretase substrate proteome and its role in cell signaling regulation(2024)
Authors: Pengfei Hou, Bart De Strooper, Renzo Mancuso
- New precision medicine avenues to the prevention of Alzheimer's disease from insights into the structure and function of γ-secretases.(2024)
Authors: Bart De Strooper
Pages: 887 - 903 - A xenograft model to study human microglia genetics, development and disease(2024)
Authors: Nicola Fattorelli, Bart De Strooper, Renzo Mancuso
- Functional and topological analysis of PSENEN, the fourth subunit of the γ-secretase complex.(2024)
Authors: An Zwijsen, Lucia Chavez Gutierrez, Bart De Strooper
Pages: 105533 - Transcriptomics to study the cellular phase of Alzheimer's Disease(2023)
Authors: Nicky Thrupp, Bart De Strooper, Mark Fiers
- Untangling the role of APOE in astrocytes and microglia in Alzheimer's disease(2023)
Authors: Pranav Preman, Bart De Strooper, Amaia Arranz Mendiguren
- The y-secretase substrate proteome and its role in cell signaling regulation(2023)
Authors: Nicola Fattorelli, Dries T'Syen, Sriram Balusu, Tom Theys, Bart De Strooper, Mark Fiers
Pages: 4106 - + - Discovery of brain permeable 2-Azabicyclo[2.2.2]octane sulfonamides as a novel class of presenilin-1 selective γ-secretase inhibitors(2023)
Authors: Bart De Strooper
- INVESTIGATING EPIGENETIC REGULATION OF MICROGLIA IN A HUMAN-MOUSE CHIMERA MODEL OF ALZHEIMER'S DISEASE(2023)
Authors: Bart De Strooper
Pages: S90 - S91
Patents
1 - 10 of 10
- Γ-secretase stabilizing compound screening assay (Inventor)
- Gamma-secretase stabilizing compound screening assay (Inventor)
- Therapeutic agents for neurological and psychiatric disorders (Inventor)
- Therapeutic agents for neurological and psychiatric disorders (Inventor)
- Single domain antibodies capable of modulating bace activity (Inventor)
- Therapeutic agents for neurological and psychiatric disorders (Inventor)
- Single domain antibodies capable of modulating bace activity (Inventor)
- Gamma-secretase stabilizing compound screening assay (Inventor)
- Restoring phosphorylation of a novel pink1 substrate to treat parkinson's disease (Inventor)
- Restoring phosphorylation of a novel pink1 substrate to treat parkinson's disease (Inventor)