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Researcher
Bart De Strooper
- Disciplines (Flanders Institute for Biotechnology):Analysis of next-generation sequence data, Cell death, Behavioural neuroscience
- Disciplines (KU Leuven):Neurosciences, Biological and physiological psychology, Cognitive science and intelligent systems, Developmental psychology and ageing
- See also: Bart De Strooper (Flanders Institute for Biotechnology)
Affiliations
- Laboratory for the Research of Neurodegenerative Diseases (VIB-KU Leuven) (Lab)
Responsible
From1 Jan 2006 → Today - Laboratory for the Research of Neurodegenerative Diseases (VIB-KU Leuven) (Lab)
Member
From1 Jan 2017 → Today - De Strooper Lab (Research group)
Responsible
From1 Jan 2017 → Today - Department of Human Genetics (Department)
Member
From1 Oct 1999 → 31 Dec 2016
Projects
1 - 10 of 80
- MEG3 activates necroptosis in human neuron xenografts modeling Alzheimer's diseaseFrom16 May 2024 → TodayFunding: Foundations, funds and other with scientific goal
- Spatial Proteomics to Investigate the Cellular Phase of Alzheimer’s DiseaseFrom13 Feb 2023 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- A novel chimeric model investigating human neurological features in Alzheimer’s diseaseFrom1 Jan 2023 → TodayFunding: FWO fellowships
- A vicious Aβ oligomers-dependent neuron-microglia cycle fuels Alzheimer's DiseaseFrom1 Jan 2023 → TodayFunding: Other federal public and semi-governmental institutions
- Human-mouse neuronal xenografts to study incipient Alzheimer’s Disease.From1 Jan 2023 → TodayFunding: FWO research project (including WEAVE projects)
- The early microglia–neuron interactions in Alzheimer’s Disease and their modulation by immunotherapyFrom1 Jan 2023 → TodayFunding: FWO research project (including WEAVE projects)
- Restoring miR-132 expression rescues adult hippocampal neurogenesis and memory deficits in Alzheimer's diseaseFrom1 May 2022 → 31 Dec 2022Funding: Foundations, funds and other with scientific goal
- Therapeutic targeting of pathogenic presynaptic Tau in human neurons in a chimeric Alzheimer’s Disease mouse modelFrom24 Jan 2022 → TodayFunding: FWO Strategic Basic Research Grant
- Genetic Risk in Alzheimer's diseaseFrom14 Jan 2022 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Functional characterization of human neurons in the human-mouse chimeric model for Alzheimer’s diseaseFrom5 Oct 2021 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
Publications
21 - 30 of 330
- CRISPR/Cas9 screen in human iPSC-derived cortical neurons identifies NEK6 as a novel disease modifier of C9orf72 poly(PR) toxicity(2023)
Authors: Wenting Guo, Elke Braems, Pegah Masrori, Evelien Van Schoor, Maarten Jacquemyn, Sriram Balusu, Tine Tricot, Pieter Vanden Berghe, Dietmar Thal, Rik Vandenberghe, et al.
Pages: 1245 - 1259 - Neurodegeneration cell per cell(2023)
Authors: Sriram Balusu, Bart De Strooper, Patrik Verstreken
Pages: 767 - 786 - Plasma biomarkers and genetics in the diagnosis and prediction of Alzheimer's disease(2023)
Authors: Bart De Strooper
Pages: 690 - 699 - Pyroptosis in Alzheimer's disease: cell type-specific activation in microglia, astrocytes and neurons(2023)
Authors: Marta Koper, Evelien Van Schoor, Jolien Schaeverbeke, Rik Vandenberghe, Thomas Tousseyn, Bart De Strooper, Dietmar Thal
Pages: 175 - 195 - Microglial Expression of the Wnt Signaling Modulator DKK2 Differs between Human Alzheimer's Disease Brains and Mouse Neurodegeneration Models.(2023)
Authors: Bart De Strooper
Pages: ENEURO.030 - ENEU22.202 - Systematic profiling of microRNA-132 functional targetome and its therapeutic potential in Alzheimer's disease(2022)
Authors: Hannah Walgrave, Bart De Strooper, Evgenia Salta
- GVD-necroptosis as a driving process of neurodegeneration in Alzheimer’s disease(2022)
Authors: Marta Koper, Dietmar Thal, Bart De Strooper
- Microglia states and nomenclature: A field at its crossroads(2022)
Authors: Bart De Strooper
Pages: 3458 - 3483 - Diabetes and Alzheimer's disease: shared genetic susceptibility?(2022)
Authors: Bart De Strooper
Pages: 962 - 964 - VHHs as tools for therapeutic protein delivery to the central nervous system(2022)
Authors: Bart De Strooper, Maarten Dewilde
Patents
1 - 10 of 10
- Γ-secretase stabilizing compound screening assay (Inventor)
- Gamma-secretase stabilizing compound screening assay (Inventor)
- Therapeutic agents for neurological and psychiatric disorders (Inventor)
- Therapeutic agents for neurological and psychiatric disorders (Inventor)
- Single domain antibodies capable of modulating bace activity (Inventor)
- Therapeutic agents for neurological and psychiatric disorders (Inventor)
- Single domain antibodies capable of modulating bace activity (Inventor)
- Gamma-secretase stabilizing compound screening assay (Inventor)
- Restoring phosphorylation of a novel pink1 substrate to treat parkinson's disease (Inventor)
- Restoring phosphorylation of a novel pink1 substrate to treat parkinson's disease (Inventor)