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Researcher
Bart De Strooper
- Disciplines (Flanders Institute for Biotechnology):Analysis of next-generation sequence data, Cell death, Behavioural neuroscience
- Disciplines (KU Leuven):Neurosciences, Biological and physiological psychology, Cognitive science and intelligent systems, Developmental psychology and ageing
- See also: Bart De Strooper (Flanders Institute for Biotechnology)
Affiliations
- Laboratory for the Research of Neurodegenerative Diseases (VIB-KU Leuven) (Lab)
Responsible
From1 Jan 2006 → Today - Laboratory for the Research of Neurodegenerative Diseases (VIB-KU Leuven) (Lab)
Member
From1 Jan 2017 → Today - De Strooper Lab (Research group)
Responsible
From1 Jan 2017 → Today - Department of Human Genetics (Department)
Member
From1 Oct 1999 → 31 Dec 2016
Projects
21 - 30 of 80
- Investigating the influence of astrocytes on functional network disruptions and amyloid pathology at early disease stages in a mouse model of Alzheimer's diseaseFrom1 Jan 2020 → 30 Apr 2023Funding: FWO research grant KAN
- Unbiased in vivo CRISPR/CAS9 kinome-wide screen to identify disease-modifying targets in Alzheimer’s diseaseFrom1 Jan 2020 → 31 Dec 2020Funding: FWO research grant KAN
- Translating individual Alzheimer genetic risk into disease phenotypes (TRIAGE).From1 Jan 2020 → 30 Jun 2023Funding: FWO research project (including WEAVE projects)
- Microglia and neuroinflammation: transducers of amyloid beta toxicity in human Alzheimer’s diseaseFrom1 Jan 2019 → 31 Dec 2022Funding: FWO research project (including WEAVE projects)
- Exploring the role of Aβ, Tau and Tau modulators in inducing neuronal death in a novel humanized mouse model for Alzheimer DiseaseFrom1 Jan 2019 → 31 Dec 2022Funding: FWO research project (including WEAVE projects)
- Untangling the role of APOE in astrocytes and microglia in Alzheimer's diseaseFrom1 Dec 2018 → 1 Dec 2022Funding: Own budget, for example: patrimony, inscription fees, gifts
- From genetics to the cellular phase of Alzheimer’s disease: untangling the role of lipid pathways in microglia responses to amyloid pathologyFrom19 Nov 2018 → 5 Feb 2024Funding: FWO fellowships
- The γ-secretase substrate proteome and its role in cell signaling regulationFrom1 Oct 2018 → 12 Mar 2024Funding: Own budget, for example: patrimony, inscription fees, gifts
- Aß, Tau and neuronal death in a novel humanized mouse model for Alzheimer DiseaseFrom1 Oct 2018 → 30 Sep 2021Funding: FWO fellowships
- Elucidating the contribution of astrocytes on functional network disruptions in a mouse model of Alzheimer’s disease.From1 Oct 2018 → 30 Sep 2021Funding: FWO fellowships
Publications
1 - 10 of 330
- Xenografted human microglia display diverse transcriptomic states in response to Alzheimer's disease-related amyloid-β pathology.(2024)
Authors: Sriram Balusu, Catherine Verfaillie, Bart De Strooper
- The γ-secretase substrate proteome and its role in cell signaling regulation(2024)
Authors: Pengfei Hou, Bart De Strooper, Renzo Mancuso
- New precision medicine avenues to the prevention of Alzheimer's disease from insights into the structure and function of γ-secretases.(2024)
Authors: Bart De Strooper
Pages: 887 - 903 - A xenograft model to study human microglia genetics, development and disease(2024)
Authors: Nicola Fattorelli, Bart De Strooper, Renzo Mancuso
- Functional and topological analysis of PSENEN, the fourth subunit of the γ-secretase complex.(2024)
Authors: An Zwijsen, Lucia Chavez Gutierrez, Bart De Strooper
Pages: 105533 - Transcriptomics to study the cellular phase of Alzheimer's Disease(2023)
Authors: Nicky Thrupp, Bart De Strooper, Mark Fiers
- Untangling the role of APOE in astrocytes and microglia in Alzheimer's disease(2023)
Authors: Pranav Preman, Bart De Strooper, Amaia Arranz Mendiguren
- The y-secretase substrate proteome and its role in cell signaling regulation(2023)
Authors: Nicola Fattorelli, Dries T'Syen, Sriram Balusu, Tom Theys, Bart De Strooper, Mark Fiers
Pages: 4106 - + - Discovery of brain permeable 2-Azabicyclo[2.2.2]octane sulfonamides as a novel class of presenilin-1 selective γ-secretase inhibitors(2023)
Authors: Bart De Strooper
- INVESTIGATING EPIGENETIC REGULATION OF MICROGLIA IN A HUMAN-MOUSE CHIMERA MODEL OF ALZHEIMER'S DISEASE(2023)
Authors: Bart De Strooper
Pages: S90 - S91
Patents
1 - 10 of 10
- Γ-secretase stabilizing compound screening assay (Inventor)
- Gamma-secretase stabilizing compound screening assay (Inventor)
- Therapeutic agents for neurological and psychiatric disorders (Inventor)
- Therapeutic agents for neurological and psychiatric disorders (Inventor)
- Single domain antibodies capable of modulating bace activity (Inventor)
- Therapeutic agents for neurological and psychiatric disorders (Inventor)
- Single domain antibodies capable of modulating bace activity (Inventor)
- Gamma-secretase stabilizing compound screening assay (Inventor)
- Restoring phosphorylation of a novel pink1 substrate to treat parkinson's disease (Inventor)
- Restoring phosphorylation of a novel pink1 substrate to treat parkinson's disease (Inventor)