Projects
Artificial intelligence-powered knowledge base of the observed molecular universe. University of Antwerp
Digital pathology as a proxy for molecular profiling of prostate tumors Ghent University
Histological images (WSIs) of tumor samples are routinely available in pathology labs and reflect the physiological phenotype of tumor cells and their genomic aberrations. Deep learning techniques offer the potential to extract from these WSIs hidden morphological features that associate with molecular properties. WSIs thus contain a largely untapped source of valuable information on the molecular properties and their spatial organization. ...
Investigation of the molecular mechanism by which iron availability in the mitochondria affect tolerance towards the anti fungal drug fluconazole in the human fungal pathogen Candida albicans KU Leuven
A novel molecular and personalized prognostic and predictive approach to inflammatory bowel diseases KU Leuven
The inflammatory bowel diseases (IBD) represent a spectrum of chronic immune-mediated disorders of the gut and extra-intestinal organs with Crohn's disease (CD) and ulcerative colitis (UC) as the two main phenotypes. There is substantial inter-individual variability in the clinical presentation and the outcome of IBD. Despite the important progress in therapeutic discovery, clinical and mucosal remission rates leave large margins for ...
Molecular basis of keratinopathies KU Leuven
Functional subset definition and molecular regulation of neutrophils and natural killer cells in infection and inflammation. KU Leuven
Molecular crystal structure prediction with computational multiscale methods Ghent University
Molecular crystal structure prediction (CSP) is an industrially relevant problem (pharma, electronics, ...) and comes in reach of state-of-the-art computational methods, as illustrated by three-yearly CSP blind tests. Computational CSP remains a non-trivial problem with fundamental challenges that will be addressed in this project. The final aim is to deliver a computational CSP methodology of interest for the pharmaceutical industry.
Pre-allocated professorship in biomedical molecular biology Ghent University
A position as pre-allocated professor grants one the privilege for a period of maximum 5 years to focus primarily on research, with a teaching load limited to no more than 8 ECTS credits per semester on average over a period of 3 years.
Molecular profiling of early events in the pathogenesis of inflammatory bowel disease KU Leuven
Inflammatory bowel disease (IBD) is characterized by a chronic inflammation of the gut and comprises two major forms: Crohn’s disease (CD) and ulcerative colitis (UC). A genetic predisposition is a risk factor for developing IBD, with a peak incidence in early adult life, and ranging beyond the sixth decade of life. It has been shown that the phenotypes of late-onset IBD differ from those in the younger population. Anti-tumor necrosis factor ...