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Organisation

Translational Research in GastroIntestinal Disorders

Division

Lifecycle:1 Jul 1977  →  Today
Organisation profile:
  • Neuromodulation of the intestinal immune system
  • Immunomodulation of afferent nerve function and visceral hypersensitivity
  • Intestinal macrophage phenotyping
  • Pathophysiology and treatment of irritable bowel syndrome
  • Pathophysiology of postoperative ileus
  • Pathophysiology of gastroesophageal reflux disease
  • Pathophysiology and treatment of achalasia
  • Neuron-glial interactions in the ENS
  • Developmental aspects of ENS functionality
  • ENS in neurodegenerative and GI disorders
  • Second harmonic imaging in neuroscience
  • Advanced microscopy
  • Nutrient sensing in the gut
  • Role of peripheral clock genes in the circadian regulation of gut peptide release
  • Role of gastrointestinal peptides and their receptors in the regulation of food intake and gastrointestinal motility
  • Ghrelin as a therapeutic target
  • Development of analytical tools to analyse the bacterial colonic metabolism
  • Evaluation of strategies to modulate bacterial colonic fermentation
  • Impact of bacterial colonic fermentation on gut health and systemic health
  • Contribution of bacterial colonic fermentation to the pathophysiology of disorders
  • Impact of bariatric surgery on bacterial colonic fermentation
  • Psychobiological mechanisms of gastrointestinal sensitivity and symptom perception in health and functional GI disorders
  • Gut-Brain signaling mechanisms in the control of appetite and food intake in health and food intake disorders
  • Influence of subliminal nutrient- and microbiota-induced gut-brain signals on psychological processes and disorders
  • Intestinal immune tolerance
  • Immunomodulatory role of enteric glia and neurons
  • Pathophysiology of food allergy
  • Enteric nervous system and inflammation
  • Therapeutic drug monitoring in Inflammatory Bowel Diseases
  • Pharmacogenetic analysis of factors involved in long-term response to biologicals in Inflammatory Bowel Diseases
  • Role of the microbiome, intestinal barrier and immune system in the pathogenesis of Inflammatory Bowel Diseases
  • intestinal organoid models in Inflammatory Bowel Diseases
  • Normal and abnormal motor activity of oesophagus, stomach, small intestine, colon and anorectum
  • Endocrine, paracrine and neurocrine peptide-untreated control mechanisms of gastrointestinal function
  • Clinical pharmacology of gastro-intestinal diseases
  • Computer analysis of manometric and electromyographic recordings and of long-term pH and pressure measurements in oesophagus 
  • In vivo and in vitro studies of smooth muscle activity
  • Intestinal perfusion studies
Keywords:Gastro-intestinal diseases, Physiopathology, Motility, Breath tests, Peptides, Neurophysiology, TARGID, Endocrinology, Gut-brain interactions, Inflammatory bowel diseases, enteric nervous system, microscopy, Immunology
Disciplines:Endocrinology and metabolic diseases, Gastro-enterology and hepatology, Biomarker discovery and evaluation, Drug discovery and development, Medicinal products, Pharmaceutics, Pharmacognosy and phytochemistry, Pharmacology, Pharmacotherapy, Toxicology and toxinology, Other pharmaceutical sciences