Organisations
Medicinal Chemistry (Rega Institute) KU Leuven
The interests of the Laboratory for Medicinal Chemistry lay in the field of peptide, nucleoside and oligonucleotide chemistry. New substances are synthesized, analyzed and evaluated for activity in vitro. In addition, molecular modeling, NMR and mass spectrometry facilities are available and these units perform supporting research.
- Development of nucleoside derivatives with antiviral (AIDS chemotherapy) and antitumoral ...
Biocrystallography KU Leuven
The design of new potential drugs is traditionally the domain of the pharmacochemist. In the last decades Quantitative Structure-Activity Relationship (QSAR)-techniques are used more and more to define the 'essential' moieties of a pharmacon. A logical evolution in the search for the relation between the 3D-structure of drugs & their biological activity is the 3D-structure analysis of the biological target molecules and the receptor- ...
Intellectual Property KU Leuven
Laboratory of Virology and Chemotherapy (Rega Institute) KU Leuven
This unit designs and develops antiviral and antitumor agents, primarily nucleoside, nucleotide or oligonucleotide analogues but also other substances which interact with enzymes involved in nucleic acid metabolism (i.e. DNA polymerase, reverse transcriptase, thymidine kinase, thymidylate kinase, nucleoside phosphorylase, dihydropyrimidine dehydrogenase, adenosine deaminase, S-adenosylhomocysteine hydrolase, IMP dehydrogenase, OMP ...
Laboratory of Protein Phosphorylation and Proteomics KU Leuven
- We investigate the regulation of (patho)physiological processes via reversible protein phosphorylation, and explore the therapeutic potential of the kinases and phosphatases involved. Focus is on Protein Kinase D (PKD) and Protein Phosphatase 2A (PP2A), but increasingly also on broader (kinome and phosphatome wide) approaches to systematically identify kinases/phosphatases that are implicated in (patho)physiological ...
Laboratory for Medical and Molecular Oncology Vrije Universiteit Brussel
As part of the Oncology Research Center, the Laboratory for Medical & Molecular Oncology (LMMO) at the VUB Faculty of Medicine engages in several major research initiatives: to study pancreatic cancer biology (Prof. Dr. Ilse Rooman), to study cancer immunotherapy including autologous dendritic cell therapies (Prof. Dr. Bart Neyns) and to advance targeted therapies for cancer in genomically defined patients (personalized medicine, ...
Medical Biochemistry University of Antwerp
Molecular Immunology (Rega Institute) KU Leuven
This unit operates in close association with the Division of Immunolbiology (A. Billiau). Together these teams investigate the immunobiology of inflammation, auto-immunity and cancer, with emphasis on the role of cytokines (interferons, interleukins, cytotoxins and chemokines) and cellular proteases (plasminigen activators, collgenases, etc.). Projects and milestones in this framework comprise: - Identification in molecular and biological ...
Organic Chemistry Vrije Universiteit Brussel
Peptides are naturally occurring molecules composed of a small number of amino acids. They control many vital functions in the organism, such as blood pressure, pain, memory, appetite, growth, ..., which make them very interesting as potential therapeutics. However, their rapid degradation and their poor oral bioavailability limits their application as drugs. Our team develops methods to make these active peptides more stable, so that their ...