Researcher
Eveline Lescrinier
- Disciplines:Biomarker discovery and evaluation, Drug discovery and development, Medicinal products, Pharmaceutics, Pharmacognosy and phytochemistry, Pharmacology, Pharmacotherapy, Toxicology and toxinology, Other pharmaceutical sciences, Bioinformatics and computational biology
Affiliations
- Medicinal Chemistry (Rega Institute) (Division)
Responsible
From1 Aug 2016 → Today - Medicinal Chemistry (Rega Institute) (Division)
Member
From1 Oct 1999 → Today
Projects
1 - 10 of 17 results
- An NMR facility tailored for biomedical researchFrom1 May 2020 → TodayFunding: FWO Medium Size Research Infrastructure
- The synthesis of nucleoside analogues as antibacterial agentsFrom10 Feb 2020 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Selection of nucleic acids aptamers with four non-canonical bases for biomedical applicationsFrom1 Jan 2020 → TodayFunding: FWO research grant KAN
- Streamlining the route of phosphonate XNA from chemistry to applicationFrom1 Oct 2019 → TodayFunding: BOF - projects, IOF - technology concept exploration
- New genetic systems with four synthetic nucleobases: towards advance therapy and synthetic biologyFrom1 Oct 2018 → TodayFunding: FWO fellowships
- Xylo- and lyxo-type phosphonate nucleic acids: Synthesis and structural analysisFrom17 Sep 2018 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Synthesis and structure determination of phosphonate oligonucleotidesFrom17 Sep 2018 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Structure and folding of XNA aptamers studied by computational and experimental methodsFrom1 Oct 2016 → TodayFunding: BOF - Doctoral projects, FWO Strategic Basic Research Grant
- Development of a xenozyme and an XNA ligase.From1 Oct 2014 → 30 Sep 2018Funding: BOF - Concerted Research Project from 1994
- Rational Design of XNA Processing EnzymesFrom22 Sep 2014 → 6 Oct 2020Funding: BOF - Doctoral projects
Publications
1 - 10 of 69 results
- Phenyltriazole-functionalized sulfamate inhibitors targeting tyrosyl- or isoleucyl-tRNA synthetase(2020)Journal: Bioorganic & Medicinal ChemistryISSN: 0968-0896Issue: 15Volume: 28
Authors: Dries De Ruysscher, Luping Pang, Charles-Alexandre Mattelaer, Manesh Nautiyal, Steff De Graef, Jozef Rozenski, Sergei Strelkov, Eveline Lescrinier, Stephen Weeks, Arthur Van Aerschot
Number of pages: 15 - The Kalimantacin Polyketide Antibiotics Inhibit Fatty Acid Biosynthesis inStaphylococcus aureusby Targeting the Enoyl-Acyl Carrier Protein Binding Site of FabI(2020)Journal: Angewandte Chemie International EditionISSN: 1433-7851Issue: 26Volume: 59
Authors: Christopher D Fage, Thomas Lathouwers, Michiel Vanmeert, Lingjie Gao, Kristof Vrancken, Eveline-Marie Lammens, Angus NM Weir, Ruben Degroote, Harry Cuppens, Simone Kosol, et al.
Pages: 10549 - 10556Number of pages: 8 - N-8-Glycosylated 8-Azapurine and Methylated Purine Nucleobases: Synthesis and Study of Base Pairing Properties(2019)Journal: Journal of Organic ChemistryISSN: 0022-3263Issue: 21Volume: 84
Authors: Piotr Leonczak, Puneet Srivastava, Omprakash Bande, Guy Schepers, Eveline Lescrinier, Piet Herdewyn
Pages: 13394 - 13409Number of pages: 16 - Discovery of fructans in Archaea(2019)Journal: Carbohydrate PolymersISSN: 0144-8617Volume: 220
Authors: Onur Kirtel, Eveline Lescrinier, Wim Van den Ende, Ebru Toksoy Öner
Pages: 149 - 156 - Rational design of an XNA ligase through docking ofunbound nucleic acids to toroidal proteins(2019)Journal: Nucleic Acids ResearchISSN: 0305-1048Issue: 13Volume: 47
Authors: Michiel Vanmeert, Jamoliddin Razzokov, Muhammad Usman Mirza, Stephen Weeks, Guy Schepers, Annemie Bogaerts, Jozef Rozenski, Matheus Froeyen, Piet Herdewyn, Vitor Bernardes Pinheiro, et al.
Pages: 1 - 12 - Synthesis and Conformation of Pentopyranoside Nucleoside Phosphonates(2019)Journal: Journal of Organic ChemistryISSN: 0022-3263Issue: 11Volume: 84
Authors: Xiaochen Li, Shrinivas Dumbre, Eveline Lescrinier, Elisabetta Groaz, Piet Herdewyn
Pages: 6589 - 6603Number of pages: 15 - Drug-carrier binding and enzymatic carrier digestion in amorphous solid dispersions containing proteins as carrier(2019)Journal: International Journal of PharmaceuticsISSN: 0378-5173Volume: 563
Authors: Timothy Pas, Alessandra Bergonzi, Eveline Lescrinier, Bjorn Vergauwen, Guy Van den Mooter
Pages: 358 - 372Number of pages: 15 - An N-terminal Ca2+-binding motif regulates the secretory pathway Ca2+/Mn2+-transport ATPase SPCA1(2019)Journal: Journal of Biological ChemistryISSN: 0021-9258Issue: 19Volume: 294
Authors: Jialin Chen, Susanne Smaardijk, Charles-Alexandre Mattelaer, Filip Pamula, Ilse Vandecaetsbeek, Jo Vanoevelen, Frank Wuytack, Eveline Lescrinier, Jan Eggermont, Peter Vangheluwe
Pages: 7878 - 7891Number of pages: 14 - Synthesis and structure-activity relationship studies of benzo[b][1,4]oxazin-3(4H)-one analogues as inhibitors of mycobacterial thymidylate synthase(2019)Journal: ChemMedChemISSN: 1860-7179Issue: 6Volume: 14
Authors: Jakub Modranka, Jiahong Li, Anastasia Parchina, Michiel Vanmeert, Shrinivas Dumbre, Mayla Salman, Hannu Myllykallio, Hubert Becker, Roeland Vanhoutte, Lia Margamuljana, et al.
Pages: 645 - 662Number of pages: 18 - Synthesis of 3 '-fluoro-4 '-amino-hexitol nucleosides with a pyrimidine nucleobase as building blocks for oligonucleotides(2019)Journal: TetrahedronISSN: 0040-4020Issue: 8Volume: 75
Authors: Amit Jabgunde, Rahul S Patil, Swarup De, Eveline Lescrinier, Steven De Jonghe, Leonid Beigelman, Piet Herdewyn
Pages: 1107 - 1114Number of pages: 8