Researcher
Eveline Lescrinier
- Disciplines:Biomarker discovery and evaluation, Drug discovery and development, Medicinal products, Pharmaceutics, Pharmacognosy and phytochemistry, Pharmacology, Pharmacotherapy, Toxicology and toxinology, Other pharmaceutical sciences, Bioinformatics and computational biology
Affiliations
- Medicinal Chemistry (Rega Institute) (Division)
Responsible
From1 Aug 2016 → Today - Medicinal Chemistry (Rega Institute) (Division)
Member
From1 Oct 1999 → Today
Projects
1 - 10 of 19 results
- Synthesis and characterization pyrimidine C-nucleoside phosphonates as a new class of RNA nucleotide mimics with therapeutic potentialFrom1 Jan 2021 → TodayFunding: FWO research project
- Molecular modelling tools to design artificial enzymesFrom18 Nov 2020 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- An NMR facility tailored for biomedical researchFrom1 May 2020 → TodayFunding: FWO Medium Size Research Infrastructure
- Synthesis of nucleoside analogues as antiviral and antibacterial agentsFrom10 Feb 2020 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Selection of nucleic acids aptamers with four non-canonical bases for biomedical applicationsFrom1 Jan 2020 → 31 Dec 2020Funding: FWO research grant KAN
- Streamlining the route of phosphonate XNA from chemistry to applicationFrom1 Oct 2019 → TodayFunding: BOF - projects, IOF - technology concept exploration
- New genetic systems with four synthetic nucleobases: towards advance therapy and synthetic biologyFrom1 Oct 2018 → TodayFunding: FWO fellowships
- Xylo- and lyxo-type phosphonate nucleic acids: Synthesis and structural analysisFrom17 Sep 2018 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Synthesis and structure determination of phosphonate oligonucleotidesFrom17 Sep 2018 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Structure and folding of XNA aptamers studied by computational and experimental methodsFrom1 Oct 2016 → 31 Dec 2020Funding: BOF - Doctoral projects, FWO Strategic Basic Research Grant
Publications
1 - 10 of 74 results
- Molecular Dynamics Simulations in Drug Discovery and Pharmaceutical Development(2021)
Authors: Outi MH Salo-Ahen, Ida Alanko, Rajendra Bhadane, Alexandre MJJ Bonvin, Rodrigo Vargas Honorato, Shakhawath Hossain, Andre H Juffer, Aleksei Kabedev, Maija Lahtela-Kakkonen, Anders Stottrup Larsen, et al.
Number of pages: 60 - Rational Design of XNA Processing Enzymes(2020)
Authors: Michiel Vanmeert, Eveline Lescrinier, Matheus Froeyen, Vitor Bernardes Pinheiro
- Synthesis and Biological Evaluation of 1,3-Dideazapurine-Like 7-Amino-5-Hydroxymethyl-Benzimidazole Ribonucleoside Analogues as Aminoacyl-tRNA Synthetase Inhibitors(2020)
Authors: Baole Zhang, Luping Pang, Manesh Nautiyal, Steff De Graef, Bharat Gadakh, Eveline Lescrinier, Jozef Rozenski, Sergei Strelkov, Stephen D Weeks, Arthur Van Aerschot
Number of pages: 24 - Phenyltriazole-functionalized sulfamate inhibitors targeting tyrosyl- or isoleucyl-tRNA synthetase(2020)
Authors: Dries De Ruysscher, Luping Pang, Charles-Alexandre Mattelaer, Manesh Nautiyal, Steff De Graef, Jozef Rozenski, Sergei Strelkov, Eveline Lescrinier, Stephen Weeks, Arthur Van Aerschot
Number of pages: 15 - The Kalimantacin Polyketide Antibiotics Inhibit Fatty Acid Biosynthesis inStaphylococcus aureusby Targeting the Enoyl-Acyl Carrier Protein Binding Site of FabI(2020)
Authors: Christopher D Fage, Thomas Lathouwers, Michiel Vanmeert, Lingjie Gao, Kristof Vrancken, Eveline-Marie Lammens, Angus NM Weir, Ruben Degroote, Harry Cuppens, Simone Kosol, et al.
Pages: 10549 - 10556Number of pages: 8 - N-8-Glycosylated 8-Azapurine and Methylated Purine Nucleobases: Synthesis and Study of Base Pairing Properties(2019)
Authors: Piotr Leonczak, Puneet Srivastava, Omprakash Bande, Guy Schepers, Eveline Lescrinier, Piet Herdewyn
Pages: 13394 - 13409Number of pages: 16 - Discovery of fructans in Archaea(2019)
Authors: Onur Kirtel, Eveline Lescrinier, Wim Van den Ende, Ebru Toksoy Öner
Pages: 149 - 156 - Application of enzyme substrate analogues: from inhibitors with anti-mycobacterial properties to synthetic genetic polymers(2019)
Authors: Rania Abou El Asrar, Piet Herdewyn, Eveline Lescrinier
- Rational design of an XNA ligase through docking ofunbound nucleic acids to toroidal proteins(2019)
Authors: Michiel Vanmeert, Jamoliddin Razzokov, Muhammad Usman Mirza, Stephen Weeks, Guy Schepers, Annemie Bogaerts, Jozef Rozenski, Matheus Froeyen, Piet Herdewyn, Vitor Bernardes Pinheiro, et al.
Pages: 1 - 12 - Synthesis and Conformation of Pentopyranoside Nucleoside Phosphonates(2019)
Authors: Xiaochen Li, Shrinivas Dumbre, Eveline Lescrinier, Elisabetta Groaz, Piet Herdewyn
Pages: 6589 - 6603Number of pages: 15