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Researcher
Dominique Schols
- Disciplines:Microbiology, Systems biology, Laboratory medicine
Affiliations
- Laboratory of Virology and Chemotherapy (Rega Institute) (Division)
Responsible
From1 Jan 2014 → Today - Laboratory of Virology and Chemotherapy (Rega Institute) (Division)
Member
From1 Oct 1999 → Today
Projects
1 - 10 of 24
- Development and preclinical evaluation of diagnostic and therapeutic radiopharmaceuticals targeting CXCR4From10 Aug 2021 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Development of allosteric intracellular modulators attenuating chemokine receptor CCR5 signallingFrom1 May 2021 → TodayFunding: BOF - doctoral mandates
- A novel class of reversible Exportin-1 inhibitors for cancer therapyFrom1 Jan 2021 → TodayFunding: IOF - technology validation in lab
- Design and synthesis of next-generation C-C chemokine receptor type 5 antagonists.From28 Jul 2020 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Intravital microscopy platform for infectious and inflammatory diseasesFrom1 May 2020 → TodayFunding: FWO Medium Size Research Infrastructure
- Discovery of CCR7 small molecule inhibitors by virtual screening andhit-to-lead optimization.From1 Oct 2019 → 30 Sep 2021Funding: BOF - projects
- Development and evaluation of new classes of CXCR2 antagonists with applications in inflammation and infectionFrom3 Sep 2019 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- A basic research pipeline for discovery and early preclinical development of host-targeted antiviral strategies to combat encephalitic alphavirusesFrom19 Jul 2018 → 30 Nov 2021Funding: Foreign public sponsor
- Establishment of in vitro assays for the discovery of GPCR small molecule ligandsFrom30 May 2018 → 30 May 2022Funding: Own budget, for example: patrimony, inscription fees, gifts
- Identification of novel chemokine receptor inhibitors for anti-cancer therapyFrom1 Oct 2017 → 30 Sep 2019Funding: BOF - Concerted Research Project from 1994
Publications
1 - 10 of 313
- Organotropic dendrons with high potency as HIV-1, HIV-2 and EV-A71 cell entry inhibitors.(2022)
Authors: Rana Abdelnabi, Johan Neyts, Dominique Schols
Pages: 114414 - Stimulation of the atypical chemokine receptor 3 (ACKR3) by a small-molecule agonist attenuates fibrosis in a preclinical liver but not lung injury model.(2022)
Authors: Tom Van Loy, Steven De Jonghe, Wouter Dheedene, Patrick Chaltin, Aernout Luttun, Dominique Schols
Pages: 293 - Discovery of 2-Phenylquinolines with Broad-Spectrum Anti-coronavirus Activity.(2022)
Authors: Laura Vangeel, Dirk Jochmans, Dominique Schols, Johan Neyts, Steven De Jonghe
Pages: 855 - 864 - Identification of novel chemotypes as CXCR2 antagonists via a scaffold hopping approach from a thiazolo[5,4-d]pyrimidine(2022)
Authors: Max Van Hoof, Katrijn Boon, Tom Van Loy, Dominique Schols, Wim Dehaen, Steven De Jonghe
Number of pages: 19 - SARS-CoV-2 Virion Infectivity and Cytokine Production in Primary Human Airway Epithelial Cells(2022)
Authors: Dominique Schols, Johan Neyts, Dirk Jochmans
Pages: 951 - Synthesis, in vitro cytotoxicity, molecular docking and ADME study of some indolin-2-one linked 1,2,3-triazole derivatives(2022)
Authors: Dominique Schols
Number of pages: 18 - Effect of Particle Carriers for Intraperitoneal Drug Delivery on the Course of Ovarian Cancer and Its Immune Microenvironment in a Mouse Model(2022)
Authors: Roxanne Wouters, Ann Vankerckhoven, Jolien Ceusters, Dominique Schols, An Coosemans
Number of pages: 16 - In silico design, synthesis and anti-HIV activity of quinoline derivatives as non-nucleoside reverse transcriptase inhibitors (NNRTIs).(2022)
Authors: Dominique Schols
Pages: 107675 - A Set of Experimentally Validated Decoys for the Human CC Chemokine Receptor 7 (CCR7) Obtained by Virtual Screening(2022)
Authors: Steven De Jonghe, Tom Van Loy, Dominique Schols
Number of pages: 13 - Innate Lymphoid Cells Are Required to Induce Airway Hyperreactivity in a Murine Neutrophilic Asthma Model(2022)
Authors: Anne-Charlotte Jonckheere, Sven Seys, Kaat Dekoster, Dominique Schols, Greetje Vande Velde, Christine Breynaert, Rik Schrijvers, Jeroen Vanoirbeek, Jan Ceuppens, Lieven Dupont, et al.
Number of pages: 15