Development and validation of a bona fide iPSC derived human neuronal infection model to evaluate antivirals targeted against neurotropic viral infections. University of Antwerp
Centre for Health Economics Research and Modelling of Infectious Diseases (CHERMID), Laboratory for Experimental Hematology (LEH), Laboratory for Microbiology, Parasitology and Hygiene (LMPH)
Neurotropic viral infections continue to cause major disease and economic burden. Such infections are most commonly caused by herpesviruses, arboviruses and enteroviruses, often leading to severe neurological damage with poor clinical outcomes. The search for interventions to prevent and/or treat these infections is however challenging. The main reason for this is the nature of the target cells, neurons, which are chiefly non-renewable and ...