Crucial Role of Gamma Interferon-Producing CD4 Th1 Cells but Dispensable Function of CD8 T Cell, B Cell, Th2, and Th17 Responses in the Control of Brucella melitensis Infection in Mice Vrije Universiteit Brussel
Brucella spp. are facultative intracellular bacterial pathogens responsible for brucellosis, a worldwide zoonosis that causes abortion in domestic animals and chronic febrile disease associated with serious complications in humans. There is currently no approved vaccine against human brucellosis, and antibiotic therapy is long and costly. Development of a safe protective vaccine requires a better understanding of the roles played by components ...