Researcher
Georges Leclercq
- Keywords:human, function, NK cells, differentiation, transcription factors
- Disciplines:Adaptive immunology, Applied immunology, Autoimmunity, Immunogenetics, Innate immunity, Hematology
Affiliations
- Department of Diagnostic Sciences (Department)
Member
From1 Oct 2018 → 28 Feb 2023 - Department of Clinical chemistry, microbiology and immunology (Department)
Member
From1 Jan 1993 → 30 Sep 2018
Projects
1 - 10 of 16
- Strengthening the UGent patent position on an improved cultivation method for adoptive cell therapies (immuno-oncology).From1 Apr 2019 → 31 Mar 2020Funding: IOF - technology concept exploration
- Innate lymphoid cells in multiple sclerosis: implications of genetic risk variantsFrom1 Jan 2018 → 31 Dec 2019Funding: Foundations, funds and other with scientific goal
- Exploring important milestones in the differentiation of human
natural killer cells and innate lymphoid cells: from stem cell to
effector.From1 Jan 2017 → 31 Dec 2020Funding: FWO Strategic Basic Research Grant
- The regulatory role of the transcription factors T-bet and Eomes in
development and function of human NK cells and innate lymphoid
cellsFrom1 Jan 2017 → 31 Dec 2020Funding: FWO Strategic Basic Research Grant
- Transcriptional regulation of differentiation of human natural killer and innate lymphoid cells.From1 Jan 2017 → 31 Dec 2020Funding: FWO research project
- A new mechanism of tumor escape from innate-like T lymphocytesFrom1 Jan 2015 → 31 Dec 2018Funding: Foundations, funds and other with scientific goal
- Transcriptional regulation of human natural killer cell and innate lymphoid cell differentiationFrom1 Oct 2014 → 24 Jun 2019Funding: BOF - Other initiatives, FWO fellowships
- The role of the transcription factors Tox and Id2 in the development of human natural killer cellsFrom1 Jan 2013 → 31 Dec 2016Funding: IWT personal funding - specialisation scholarships
- The role of the Ly49E receptor in the differentiation and function of natural killer celles and innate-like TFrom1 Jan 2013 → 31 Dec 2018Funding: FWO research project
- The role of the transcription factors Ets-1, E4BP4 and GATA-3 in the development of human natural killer cells.From1 Oct 2012 → 1 Oct 2014Funding: BOF - Other initiatives
Publications
1 - 10 of 78
- Severe COVID-19 patients display hyper-activated NK cells and NK cell-platelet aggregates(2022)
Authors: Bert Malengier-Devlies, Jessica Filtjens, Kourosh Ahmadzadeh, Bram Boeckx, Jessica Vandenhaute, Amber De Visscher, Eline Bernaerts, Tania Mitera, Cato Jacobs, Lore Vanderbeke, et al.
- TXNIP promotes human NK cell development but is dispensable for NK cell functionality(2022)
Authors: Eva Persyn, Sigrid Wahlen, Laura Kiekens, Sylvie Taveirne, Wouter Van Loocke, Els Van Ammel, Filip Van Nieuwerburgh, Tom Taghon, Bart Vandekerckhove, Pieter Van Vlierberghe, et al.
- Small-scale manufacturing of neoantigen-encoding messenger RNA for early-phase clinical trials(2022)
Authors: Joline Ingels, Laurenz De Cock, Rupert Mayer, Pam Devreker, Karin Weening, Nele Lootens, Saskia De Smet, Marieke Brusseel, Stijn De Munter, Melissa Pille, et al.
Pages: 213 - 222 - HES1 and HES4 have non-redundant roles downstream of Notch during early human T-cell development(2021)
Authors: Matthias De Decker, Marieke Lavaert, Juliette Roels, Laurentijn Tilleman, Bart Vandekerckhove, Georges Leclercq, Filip Van Nieuwerburgh, Pieter Van Vlierberghe, Tom Taghon
Pages: 130 - 141 - Treatment of a patient with severe cytomegalovirus (CMV) infection after haploidentical stem cell transplantation with donor-derived CMV-specific T cells(2021)
Authors: Joline Ingels, Saskia De Smet, Kelly Heyns, Nele Lootens, Jonas Segaert, Tom Taghon, Georges Leclercq, Karim Vermaelen, Evelyne Willems, Etienne Baudoux, et al.
Pages: 482 - 486 - In vitro OP9-DL1 co-culture and subsequent maturation in the presence of IL-21 generates tumor antigen-specific T cells with a favorable less-differentiated phenotype and enhanced functionality(2021)
Authors: Sarah Bonte, Stijn De Munter, Lore Billiet, Glenn Goetgeluk, Joline Ingels, Hanne Jansen, Melissa Pille, Laurenz De Cock, Karin Weening, Tom Taghon, et al.
- A novel non-coding variant in DCLRE1C results in deregulated splicing and induces SCID through the generation of a truncated ARTEMIS protein that fails to support V(D)J recombination and DNA damage repair(2021)
Authors: Steven Strubbe, Marieke De Bruyne, Ulrich Pannicke, Elien Beyls, Bart Vandekerckhove, Georges Leclercq, Elfride De Baere, Victoria Bordon, Anne Vral, Klaus Schwarz, et al.
- T-cells with a single tumor antigen-specific T-cell receptor can be generated in vitro from clinically relevant stem cell sources(2020)
Authors: Sarah Bonte, Stijn De Munter, Glenn Goetgeluk, Joline Ingels, Melissa Pille, Lore Billiet, Tom Taghon, Georges Leclercq, Bart Vandekerckhove, Tessa Kerre
- Human thymic CD10+ PD-1+ intraepithelial lymphocyte precursors acquire interleukin-15 responsiveness at the CD1aU+2013 CD95+ CD28U+2013 CCR7U+2013 developmental stage(2020)
Authors: Lore Billiet, Glenn Goetgeluk, Sarah Bonte, Stijn De Munter, Laurenz De Cock, Melissa Pille, Joline Ingels, Hanne Jansen, Karin Weening, Filip Van Nieuwerburgh, et al.
- Distinct Notch1 and BCL11B requirements mediate human U+03B3U+03B4/U+03B1U+03B2 T cell development(2020)
Authors: Anne-Catherine Dolens, Kaat Durinck, Marieke Lavaert, Joni Van der Meulen, Imke Velghe, Jelle De Medts, Karin Weening, Juliette Roels, Katrien De Mulder, Pieter-Jan Volders, et al.