Researcher
Tom Taghon
- Disciplines:Developmental biology , Hematology not elsewhere classified, Immunology not elsewhere classified
Affiliations
- Department of Diagnostic Sciences (Department)
Member
From1 Oct 2018 → Today - Dean's Office of the Faculty of Medicine and Health Sciences (Administrative office)
Member
From1 Jul 2002 → 31 Oct 2002 - Department of Clinical chemistry, microbiology and immunology (Department)
Member
From1 Jan 1998 → 30 Sep 2018
Projects
1 - 10 of 35
- Deregulated mRNA transcription and protein translation in the transformation of normal T-cells to malignant cells.From1 Jan 2023 → TodayFunding: BOF - iBOF
- Cofunding core facility - Flow cytometryFrom1 Nov 2022 → TodayFunding: BOF - research organisations
- Unraveling the Role of GATA3 in B-Cell Precursor Acute Lymphoblastic LeukemiaFrom1 Nov 2022 → TodayFunding: BOF - postdoctoral mandates
- Identification of the molecular drivers of ab vs. gd T cell development at single cell resolution in humanFrom1 Oct 2022 → TodayFunding: FWO junior postdoctoral fellowship
- SpatialConnect: linking tissue biology to the new era of single-cell spatial transcriptomicsFrom1 May 2022 → TodayFunding: FWO Medium Size Research Infrastructure
- The generation of bona fide T cell precursors for cell therapyFrom15 Apr 2022 → TodayFunding: IOF - technology validation in lab
- Functional analysis of the RNA helicase DHX15 in T-cell acutelymphoblastic leukemiaFrom1 Jan 2022 → TodayFunding: FWO research project
- Deciphering the functional phenotype of U+03B3U+03B4 T cells in spondyloarthritis.From1 Oct 2021 → 31 Oct 2021Funding: BOF - doctoral mandates
- Origin and molecular drivers of T cell and dendritic cell development in the human thymus.From1 Oct 2021 → TodayFunding: BOF - projects
- Rapid ex-vivo detection, quantification and characterisation of cell-mediated immune responses induced by natural infection or vaccination with SARS-CoV-2 orr other pathogens.From1 Apr 2021 → TodayFunding: IOF - technology validation in lab
Publications
1 - 10 of 121
- TXNIP promotes human NK cell development but is dispensable for NK cell functionality(2022)
Authors: Eva Persyn, Sigrid Wahlen, Laura Kiekens, Sylvie Taveirne, Wouter Van Loocke, Els Van Ammel, Filip Van Nieuwerburgh, Tom Taghon, Bart Vandekerckhove, Pieter Van Vlierberghe, et al.
- A DL-4-and TNF alpha-based culture system to generate high numbers of nonmodified or genetically modified immunotherapeutic human T-lymphoid progenitors(2021)
Authors: Ranjita Devi Moirangthem, Kuiying Ma, Sabrina Lizot, Anne Cordesse, Juliette Olivre, Corinne de Chappedelaine, Akshay Joshi, Agata Cieslak, John Tchen, Nicolas Cagnard, et al.
Pages: 1662 - 1676 - HES1 and HES4 have non-redundant roles downstream of Notch during early human T-cell development(2021)
Authors: Matthias De Decker, Marieke Lavaert, Juliette Roels, Laurentijn Tilleman, Bart Vandekerckhove, Georges Leclercq, Filip Van Nieuwerburgh, Pieter Van Vlierberghe, Tom Taghon
Pages: 130 - 141 - Modeling of human T cell development in vitro as a read-out for hematopoietic stem cell multipotency(2021)
Authors: Steven Strubbe, Tom Taghon
Pages: 2113 - 2122 - A novel non-coding variant in DCLRE1C results in deregulated splicing and induces SCID through the generation of a truncated ARTEMIS protein that fails to support V(D)J recombination and DNA damage repair(2021)
Authors: Steven Strubbe, Marieke De Bruyne, Ulrich Pannicke, Elien Beyls, Bart Vandekerckhove, Georges Leclercq, Elfride De Baere, Victoria Bordon, Anne Vral, Klaus Schwarz, et al.
- In vitro OP9-DL1 co-culture and subsequent maturation in the presence of IL-21 generates tumor antigen-specific T cells with a favorable less-differentiated phenotype and enhanced functionality(2021)
Authors: Sarah Bonte, Stijn De Munter, Lore Billiet, Glenn Goetgeluk, Joline Ingels, Hanne Jansen, Melissa Pille, Laurenz De Cock, Karin Weening, Tom Taghon, et al.
- A tumor suppressor enhancer of PTEN in T-cell development and leukemia(2021)
Authors: L Tottone, O Lancho, JW Loh, A Singh, S Kimura, Juliette Roels, Anna Kuchmiy, Steven Strubbe, MA Lawlor, V da Silva-Diz, et al.
Pages: 93 - 109 - Thymic epithelial cell alterations and defective thymopoiesis lead to central and peripheral tolerance perturbation in MHCII deficiency(2021)
Authors: Francesca Ferrua, Ileana Bortolomai, Elena Fontana, Dario Di Silvestre, Rosita Rigoni, Genni Enza Marcovecchio, Elena Draghici, Francesca Brambilla, Maria Carmina Castiello, Gloria Delfanti, et al.
- The RNA Atlas expands the catalog of human non-coding RNAs (June, 10.1038/s41587-021-00936-1, 2021)(2021)
Authors: Lucia Lorenzi, Hua-Sheng Chiu, Francisco Avila Cobos, Stephen Gross, Pieter-Jan Volders, Robrecht Cannoodt, Justine Nuytens, Katrien Vanderheyden, Jasper Anckaert, Steve Lefever, et al.
Pages: 1467 - 1467 - Treatment of a patient with severe cytomegalovirus (CMV) infection after haploidentical stem cell transplantation with donor-derived CMV-specific T cells(2021)
Authors: Joline Ingels, Saskia De Smet, Kelly Heyns, Nele Lootens, Jonas Segaert, Tom Taghon, Georges Leclercq, Karim Vermaelen, Evelyne Willems, Etienne Baudoux, et al.
Pages: 482 - 486