Researcher
Zeger Debyser
- Disciplines:Laboratory medicine, Microbiology, Systems biology, Biomaterials engineering, Biological system engineering, Biomechanical engineering, Other (bio)medical engineering, Environmental engineering and biotechnology, Industrial biotechnology, Other biotechnology, bio-engineering and biosystem engineering
Affiliations
- Molecular Virology and Gene Therapy (Division)
Responsible
From1 Jan 2012 → Today - Molecular Virology and Gene Therapy (Division)
Member
From1 Jan 2013 → Today - Faculty of Medicine, Kulak Kortrijk Campus (Faculty)
Member
From1 Oct 2003 → 29 Feb 2008 - Faculty of Medicine (Faculty)
Member
From1 Oct 1999 → 30 Sep 2003
Projects
1 - 10 of 77
- Bottom-up manufacturing of artificial anti-tumor T cellsFrom1 Feb 2024 → TodayFunding: HORIZON.3.1 - European Innovation Council (EIC)
- DEVELOPMENT OF LINE-1 INHIBITORSFrom1 Oct 2023 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Design of targeted degraders of LEDGF/p75 with applications as anticancer agentsFrom25 Sep 2023 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- HIV Latency and the epigenetic landscape: studying individual patients for developing HIV cure strategiesFrom1 Mar 2023 → TodayFunding: Geopolitical funding in general (R&D collaboration with Central and Eastern Europe
- Towards a functional cure strategy of HIV infection: Single virus imaging to study the impact of HIV nuclear import and integration on transcription and latencyFrom1 Sep 2022 → TodayFunding: FWO Strategic Basic Research Grant
- INNOVATIVE THERAPIES FOR LINE-1 DISEASEFrom1 May 2022 → TodayFunding: BOF - various
- Single virus live imaging of HIV nuclear import and integrationFrom1 Jan 2022 → TodayFunding: FWO research project (including WEAVE projects)
- Targeting LEDGF/p75 for Mixed Lineage Leukemia and chemoresistant malignanciesFrom16 Oct 2021 → TodayFunding: FWO Strategic Basic Research Grant
- Role of the epigenetic reader LEDGF/p75 in health and diseaseFrom1 Oct 2021 → TodayFunding: Fund Recuperation Fiscal Exemption, BOF - projects
- Role of the interaction between LEDGF and MeCP2 in LINE-1 retrotransposition in the brainFrom1 Sep 2021 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
Publications
41 - 50 of 305
- The mutation of Transportin 3 gene that causes limb girdle muscular dystrophy 1F induces protection against HIV-1 infection(2019)
Authors: Susana Neves Rocha, Frauke Christ, Zeger Debyser
- Structure and function of nucleoprotein complexes involved in retroviral integration(2019)
Authors: Tine Brouns, Steven De Feyter, Zeger Debyser, Willem Vanderlinden
- Impact of LEDGIN treatment during virus production on residual HIV-1 transcription(2019)
Authors: Greet Vansant, Irena Zurnic, Dominique Van Looveren, Rik Gijsbers, Frauke Christ, Zeger Debyser
- Synthesis and Anti-HIV Profile of a Novel Tetrahydroindazolylbenzamide Derivative Obtained by Oxazolone Chemistry(2019)
Authors: Frauke Christ, Zeger Debyser
Pages: 398 - 401 - Targeted editing of the PSIP1 gene encoding LEDGF/p75 protects cells against HIV infection(2019)
Authors: Youlia Lampi, Dominique Van Looveren, Simon Bornschein, Zeger Debyser, Rik Gijsbers
- Post-mitotic BET-induced reshaping of integrase quaternary structure supports wild-type MLV integration(2019)
Authors: Doortje Borrenberghs, Irena Zurnic, Flore De Wit, Aline Acke, Lieve Dirix, Zeger Debyser, Jelle Hendrix
Pages: 1195 - 1210 - Propargylated Purine Deoxynucleosides: New Tools for Fluorescence Imaging Strategies(2019)
Authors: Flore De Wit, Eveline Lescrinier, Zeger Debyser, Arthur Van Aerschot
- Establishment of latent HIV-1 reservoirs: what do we really know?(2019)
Authors: Anne Bruggemans, Zeger Debyser
Pages: 3 - 9 - Insight in HIV Integration Site Selection Provides a Block-and-Lock Strategy for a Functional Cure of HIV Infection(2019)
Authors: Zeger Debyser, Greet Vansant, Anne Bruggemans, Julie Janssens, Frauke Christ
- Synthesis, Molecular odelling and Biological Studies of 3-hydroxypyrane-4-one and 3-hydroxy-nyridine-4-one Derivatives as HIV-1 Integrase Inhibitors(2019)
Authors: Frauke Christ, Zeger Debyser
Pages: 755 - 770
Patents
1 - 9 of 9
- Functional cure of retroviral infection (Inventor)
- Functional cure of retroviral infection (Inventor)
- Thieno[2,3-b]pyridine derivatives as viral replication inhibitors (Inventor)
- Functional cure of retroviral infection (Inventor)
- Thieno [2, 3-B] pyridine derivatives as viral replication inhibitors (Inventor)
- ;Antiviral compounds (Inventor)
- THIENO [2, 3-B] PYRIDINE DERIVATIVES AS VIRAL REPLICATION INHIBITORS (Inventor)
- NOVEL ANTIVIRAL COMPOUNDS (Inventor)
- VIRAL REPLICATION INHIBITORS (Inventor)