Researcher
Zeger Debyser
- Disciplines:Laboratory medicine, Microbiology, Systems biology, Biomaterials engineering, Biological system engineering, Biomechanical engineering, Other (bio)medical engineering, Environmental engineering and biotechnology, Industrial biotechnology, Other biotechnology, bio-engineering and biosystem engineering
Affiliations
- Molecular Virology and Gene Therapy (Division)
Responsible
From1 Jan 2012 → Today - Molecular Virology and Gene Therapy (Division)
Member
From1 Jan 2013 → Today - Faculty of Medicine, Kulak Kortrijk Campus (Faculty)
Member
From1 Oct 2003 → 29 Feb 2008 - Faculty of Medicine (Faculty)
Member
From1 Oct 1999 → 30 Sep 2003
Projects
1 - 10 of 77
- Bottom-up manufacturing of artificial anti-tumor T cellsFrom1 Feb 2024 → TodayFunding: HORIZON.3.1 - European Innovation Council (EIC)
- DEVELOPMENT OF LINE-1 INHIBITORSFrom1 Oct 2023 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Design of targeted degraders of LEDGF/p75 with applications as anticancer agentsFrom25 Sep 2023 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- HIV Latency and the epigenetic landscape: studying individual patients for developing HIV cure strategiesFrom1 Mar 2023 → TodayFunding: Geopolitical funding in general (R&D collaboration with Central and Eastern Europe
- Towards a functional cure strategy of HIV infection: Single virus imaging to study the impact of HIV nuclear import and integration on transcription and latencyFrom1 Sep 2022 → TodayFunding: FWO Strategic Basic Research Grant
- INNOVATIVE THERAPIES FOR LINE-1 DISEASEFrom1 May 2022 → TodayFunding: BOF - various
- Single virus live imaging of HIV nuclear import and integrationFrom1 Jan 2022 → TodayFunding: FWO research project (including WEAVE projects)
- Targeting LEDGF/p75 for Mixed Lineage Leukemia and chemoresistant malignanciesFrom16 Oct 2021 → TodayFunding: FWO Strategic Basic Research Grant
- Role of the epigenetic reader LEDGF/p75 in health and diseaseFrom1 Oct 2021 → TodayFunding: Fund Recuperation Fiscal Exemption, BOF - projects
- Role of the interaction between LEDGF and MeCP2 in LINE-1 retrotransposition in the brainFrom1 Sep 2021 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
Publications
21 - 30 of 305
- LEDGINs, Inhibitors of the Interaction Between HIV-1 Integrase and LEDGF/p75, Are Potent Antivirals with a Potential to Cure HIV Infection(2021)
Authors: Zeger Debyser, Anne Bruggemans, Siska Van Belle, Julie Janssens, Frauke Christ
Pages: 97 - 114 - Molecular Mechanism of LEDGF/p75 Dimerization(2020)
Authors: Tine Brouns, Frauke Christ, Zeger Debyser
Pages: 1288 - + - Y-box-binding protein 1 supports the early and late steps of HIV replication (vol 13, e0200080, 2018)(2020)
Authors: Caroline Weydert, Bart van Heertum, Lieve Dirix, Stephanie De Houwer, Flore De Wit, Jan Mast, Steven J Husson, Katrien Busschots, Renate Konig, Rik Gijsbers, et al.
- Author Correction: Allele specific repair of splicing mutations in cystic fibrosis through AsCas12a genome editing.(2020)
Authors: Giulia Maule, Antonio Casini, Claudia Montagna, Anabela Santo Ramalho Venâncio, Kris De Boeck, Zeger Debyser, Marianne Carlon, Gianluca Petris, Anna Cereseto
Pages: 5457 - Imaging the Replication of Single Viruses: Lessons Learned from HIV and Future Challenges To Overcome(2020)
Authors: Susana Neves Rocha, Jelle Hendrix, Zeger Debyser, Johan Hofkens
Pages: 10775 - 10783 - The chromatin landscape at the HIV-1 provirus integration site determines viral expression(2020)
Authors: Greet Vansant, Zeger Debyser
Pages: 7801 - 7817 - Correction to: HIV-1 IN/Pol recruits LEDGF/p75 into viral particles.(2020)
Authors: Belete Ayele Desimmie, Caroline Weydert, Rik Schrijvers, Sofie Vets, Jonas Demeulemeester, Paul Proost, Igor Paron, Jan De Rijck, Jan Mast, Norbert Bannert, et al.
Pages: 23 - Genome editing strategies to restore altered splicing events(2020)
Authors: Giulia Maule, Zeger Debyser, Anna Cereseto, Marianne Carlon
- Capsid-Labelled HIV To Investigate the Role of Capsid during Nuclear Import and Integration(2020)
Authors: Veerle Lemmens, Susana Neves Rocha, Frauke Christ, Jelle Hendrix, Johan Hofkens, Zeger Debyser
- Phenotyping of Rare CFTR Mutations Reveals Distinct Trafficking and Functional Defects(2020)
Authors: Marjolein Ensinck, Liesbeth De Keersmaecker, Lise Heylen, Anabela Santo Ramalho Venâncio, Rik Gijsbers, Ricard Farré Marti, Christiane De Boeck, Frauke Christ, Zeger Debyser, Marianne Carlon
Pages: 1 - 14
Patents
1 - 9 of 9
- Functional cure of retroviral infection (Inventor)
- Functional cure of retroviral infection (Inventor)
- Thieno[2,3-b]pyridine derivatives as viral replication inhibitors (Inventor)
- Functional cure of retroviral infection (Inventor)
- Thieno [2, 3-B] pyridine derivatives as viral replication inhibitors (Inventor)
- ;Antiviral compounds (Inventor)
- THIENO [2, 3-B] PYRIDINE DERIVATIVES AS VIRAL REPLICATION INHIBITORS (Inventor)
- NOVEL ANTIVIRAL COMPOUNDS (Inventor)
- VIRAL REPLICATION INHIBITORS (Inventor)