Targeting LEDGF/p75 for Mixed Lineage Leukemia and chemoresistant malignancies

The host lab has recently shown that depletion of LEDGF/p75 sensitizes leukemic cells to cytostatic drugs. In my project I will study the underlying mechanism and investigate whether the same phenotype can be detected in other cancer cells. I also will develop inhibitors targeting the PWWP domain of LEDGF/p75.