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Researcher
Zeger Debyser
- Disciplines:Laboratory medicine, Microbiology, Systems biology, Biomaterials engineering, Biological system engineering, Biomechanical engineering, Other (bio)medical engineering, Environmental engineering and biotechnology, Industrial biotechnology, Other biotechnology, bio-engineering and biosystem engineering
Affiliations
- Molecular Virology and Gene Therapy (Division)
Responsible
From1 Jan 2012 → Today - Molecular Virology and Gene Therapy (Division)
Member
From1 Jan 2013 → Today - Faculty of Medicine, Kulak Kortrijk Campus (Faculty)
Member
From1 Oct 2003 → 29 Feb 2008 - Faculty of Medicine (Faculty)
Member
From1 Oct 1999 → 30 Sep 2003
Projects
71 - 77 of 77
- The use of cellular cofactors of HIV integrase as a basis for gene therapy.From1 Oct 2008 → 31 Dec 2012Funding: IWT personal funding - strategic basic research grants
- Gene therapy for HIV/AIDS based on the interaction of HIV-integrase with LEDGF/p75.From1 Oct 2008 → 7 Dec 2012Funding: FWO fellowships
- Novel HIV inhibitors targeting the interaction between integrase and LEDGF/p75From1 Sep 2008 → 12 Dec 2012Funding: BOF - Doctoral projects
- Identification and validation of cellular cofactors of retroviral integration.From1 Feb 2008 → 31 Jul 2017Funding: IWT personal funding - strategic basic research grants
- Molecular mechanism of LEDGF/p75 as co-factor of HIV-1 integration.From1 Jan 2008 → 31 Dec 2011Funding: FWO research project (including WEAVE projects)
- Validation of new cofactors of HIV integration as targets for antiviral therapy.From1 Jan 2008 → 28 Apr 2017Funding: IWT personal funding - strategic basic research grants
- From target identification to drug discoveryFrom1 Oct 2007 → TodayFunding: IOF - Industrial Research Fund, IOF - mandates
Publications
1 - 10 of 305
- New latency-promoting agents for a block-and-lock functional cure strategy.(2024)
Authors: Eline Pellaers, Zeger Debyser
- The Impact of Lens Epithelium-Derived Growth Factor p75 Dimerization on Its Tethering Function(2024)
Authors: Siska Van Belle, Zeger Debyser
- The HIV-2 OGH double reporter virus shows that HIV-2 is less cytotoxic and less sensitive to reactivation from latency than HIV-1 in cell culture(2023)
Authors: Anne Bruggemans, Zeger Debyser
- Particle-based phasor-FLIM-FRET resolves protein-protein interactions inside single viral particles(2023)
Authors: Quinten Coucke, Guillermo Solís Fernández, Johan Hofkens, Zeger Debyser, Jelle Hendrix
- Development of novel therapeutic strategies for rare CFTR mutations causing severe cystic fibrosis(2023)
Authors: Marjolein Ensinck, Zeger Debyser, Christiane De Boeck, Marianne Carlon
- Determinants of Retroviral Integration and Implications for Gene Therapeutic MLV-Based Vectors and for a Cure for HIV-1 Infection(2023)
Authors: Eline Pellaers, Anayat Bhat, Frauke Christ, Zeger Debyser
- Development of a new therapeutic strategy for the treatment of MLL-rearranged acute leukemia(2022)
Authors: Siska Van Belle, Zeger Debyser, Frauke Christ
- Single-Cell Imaging Shows That the Transcriptional State of the HIV-1 Provirus and Its Reactivation Potential Depend on the Integration Site(2022)
Authors: Zeger Debyser
- Design, synthesis, in silico studies, and antiproliferative evaluations of novel indolin-2-one derivatives containing 3-hydroxy-4-pyridinone fragment(2022)
Authors: Siska Van Belle, Zeger Debyser, Frauke Christ
- Expansion microscopy allows high resolution single cell analysis of epigenetic readers(2022)
Authors: Boris Louis, Susana Neves Rocha, Thierry Voet, Zeger Debyser, Johan Hofkens
Patents
1 - 9 of 9
- Functional cure of retroviral infection (Inventor)
- Functional cure of retroviral infection (Inventor)
- Thieno[2,3-b]pyridine derivatives as viral replication inhibitors (Inventor)
- Functional cure of retroviral infection (Inventor)
- Thieno [2, 3-B] pyridine derivatives as viral replication inhibitors (Inventor)
- ;Antiviral compounds (Inventor)
- THIENO [2, 3-B] PYRIDINE DERIVATIVES AS VIRAL REPLICATION INHIBITORS (Inventor)
- NOVEL ANTIVIRAL COMPOUNDS (Inventor)
- VIRAL REPLICATION INHIBITORS (Inventor)