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Researcher
Zeger Debyser
- Disciplines:Other biological sciences, Laboratory medicine, Palliative care and end-of-life care, Regenerative medicine, Other basic sciences, Other health sciences, Nursing, Other paramedical sciences, Other translational sciences, Other medical and health sciences
Affiliations
- Molecular Virology and Gene Therapy (Division)
Member
From1 Jan 2013 → Today - Molecular Virology and Gene Therapy (Division)
Responsible
From1 Jan 2012 → Today - Faculty of Medicine (Faculty)
Member
From1 Oct 1999 → 30 Sep 2003
Projects
1 - 10 of 72
- Towards a functional cure strategy of HIV infection: Single virus imaging to study the impact of HIV nuclear import and integration on transcription and latencyFrom20 Jul 2022 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Single virus live imaging of HIV nuclear import and integrationFrom1 Jan 2022 → TodayFunding: FWO research project
- Understanding the role of LEDGF/p75 and HRP-2 expression in cell survival and chemoresistanceFrom12 Oct 2021 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Role of the epigenetic reader LEDGF/p75 in health and diseaseFrom1 Oct 2021 → TodayFunding: BOF - projects, Fund Recuperation Fiscal Exemption
- Epigenetic regulation of HIV transcription: Towards a block-and- lock functional cureFrom16 Jul 2021 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Role of the interaction between LEDGF and MeCP2 in LINE-1 retrotransposition in the brainFrom16 Jul 2021 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Towards a functional cure of HIV infectionFrom9 Feb 2021 → 31 May 2021Funding: Own budget, for example: patrimony, inscription fees, gifts
- Cystic fibrosis is not only an ion channel defect - investigation of the role of senescence in chronic inflammation as a novel therapeutic strategyFrom17 Dec 2020 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- OrganID: Organ-derived complex 2D/3D cultures in human diseaseFrom1 Oct 2020 → TodayFunding: FWO Strategic Basic Research (SBO)
- A gene editing strategy for refractory CFTR mutations causing cystic fibrosis.From3 Sep 2020 → TodayFunding: Other federal public and semi-governmental institutions
Publications
1 - 10 of 285
- Novel CFTR modulator combinations maximise rescue of G85E and N1303K in rectal organoids(2022)
Authors: Marjolein Ensinck, Senne Cuyx, Lieven Dupont, Frauke Christ, Zeger Debyser, François Vermeulen, Marianne Carlon
Number of pages: 12 - Studying an array of biological questions at the nanoscale with Expansion Microscopy: From cells to viruses(2022)
Authors: Aline Acke, Johan Hofkens, Susana Neves Rocha, Zeger Debyser
- A ubiquitous disordered protein interaction module orchestrates transcription elongation(2021)
Authors: Jonas Demeulemeester, Zeger Debyser
Pages: 1113 - +Number of pages: 59 - CRISPR/Cas9-Induced Mutagenesis Corroborates the Role of Transportin-SR2 in HIV-1 Nuclear Import(2021)
Authors: Julie Janssens, Rik Gijsbers, Frauke Christ, Zeger Debyser
Number of pages: 22 - Role of Transportin-SR2 in HIV-1 Nuclear Import(2021)
Authors: Ivan Nombela Diaz, Julie Janssens, Frauke Christ, Zeger Debyser
Number of pages: 16 - GS-9822, a preclinical LEDGIN candidate, displays a block-and-lock phenotype in cell culture(2021)
Authors: Anne Bruggemans, Frauke Christ, Zeger Debyser
Number of pages: 17 - LEDGF/p75-mediated chemoresistance of mixed-lineage leukemia involves cell survival pathways and super enhancer activators(2021)
Authors: Siska Van Belle, Marianne Carlon, Frauke Christ, Zeger Debyser
Pages: 133 - 140Number of pages: 8 - Towards a functional cure of HIV-1: insight in the chromatin landscape of the provirus(2021)
Authors: Julie Janssens, Anne Bruggemans, Frauke Christ, Zeger Debyser
Number of pages: 12 - LEDGINs, Inhibitors of the Interaction Between HIV-1 Integrase and LEDGF/p75, Are Potent Antivirals with a Potential to Cure HIV Infection(2021)
Authors: Zeger Debyser, Anne Bruggemans, Siska Van Belle, Julie Janssens, Frauke Christ
Pages: 97 - 114Number of pages: 18 - Unlike its Paralog LEDGF/p75, HRP-2 Is Dispensable for MLL-R Leukemogenesis but Important for Leukemic Cell Survival(2021)
Authors: Siska Van Belle, Frauke Christ, Zeger Debyser
Number of pages: 18