Researcher
Wim Annaert
- Disciplines (Flanders Institute for Biotechnology):Analysis of next-generation sequence data, Cell death, Behavioural neuroscience
- Disciplines (KU Leuven):Intracellular compartments and transport
- See also: Annaert Wim (Flanders Institute for Biotechnology)
Affiliations
- Laboratory of Membrane Trafficking (VIB-KU Leuven) (Lab)
Responsible
From1 Jan 2006 → Today - Laboratory of Membrane Trafficking (VIB-KU Leuven) (Lab)
Member
From1 Jan 2017 → Today - Annaert Lab (Research group)
Responsible
From1 Jan 2017 → Today - Department of Human Genetics (Department)
Member
From1 Oct 1999 → 31 Dec 2016
Projects
1 - 10 of 45
- Impact of neuronal lysosomal dysfunction on RNA transport and local translation in Alzheimer’s diseaseFrom15 Nov 2022 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Unraveling a novel role for PSEN2/?-secretase in late endosome/lysosome-endoplasmic reticulum contact sites: impact on Alzheimer’s disease pathogenesisFrom1 Oct 2022 → TodayFunding: FWO junior postdoctoral fellowship
- Unraveling the unprecedented roles for Presenilin/?-secretase in inter-organellar membrane contact sites and how this modulates cellular calcium homeostasisFrom1 Oct 2022 → TodayFunding: FWO senior postdoctoral fellowship
- 3D SUper-Resolution to cryo-Electron MIcroscopy to study nanoscale subcellular dynamics and structure that alter in Neurodegenerative Diseases - 3SURE MINDFrom1 May 2022 → TodayFunding: FWO Large scale research infrastructure
- The impact of lysosomal Phospholipase D3 deficiency on activated response microglia regulationFrom1 Oct 2021 → TodayFunding: FWO fellowships
- Inter-organelle communication through membrane contact sites in oncology and neurodegenerative diseases (InterAction)From1 Oct 2021 → TodayFunding: Fund Recuperation Fiscal Exemption, BOF - projects
- The role of Rer1 in ER-related homeostatic mechanismsFrom1 Jan 2021 → 31 Dec 2021Funding: Own budget, for example: patrimony, inscription fees, gifts
- Dynamic super-resolution microscopy: a gateway for cell biologists to understand molecular machines at work in living cells during homeostasis & diseaseFrom1 Jan 2021 → 31 Dec 2022Funding: BOF - scientific equipment program
- The lysosomal exonuclease PLD3 as an endolysosomal flux regulator: impact on neuronal homeostasis and relevance in neurodegeneration.From1 Oct 2020 → 30 Sep 2023Funding: FWO junior postdoctoral fellowship
- Lysosomal Homeostasis in Alzheimer's diseaseFrom25 Sep 2020 → 11 Dec 2020Funding: Own budget, for example: patrimony, inscription fees, gifts
Publications
1 - 10 of 89
- Accumulation of APP C-terminal fragments causes endolysosomal dysfunction through the dysregulation of late endosome to lysosome-ER contact sites.(2024)
Authors: Zoë Van Acker, Anna Perdok, Wim Annaert
Pages: S1534-5807 - Maintenance of proteostasis by Drosophila Rer1 is essential for competitive cell survival and Myc-driven overgrowth.(2024)
Authors: Wim Annaert
Pages: e1011171 - A TCF4-dependent gene regulatory network confers resistance to immunotherapy in melanoma(2024)
Authors: Dennis Pedri, Ewout Landeloos, Yannick Van Herck, Katy Vandereyken, Thierry Voet, Wim Annaert, Diether Lambrechts, Veerle Boecxstaens, Joost van den Oord, Francesca Bosisio, et al.
- Deciphering melanoma transcriptional heterogeneity: TCF4 and the mesenchymal-like switch(2023)
Authors: Dennis Pedri, Wim Annaert, Chris Marine
- Phospholipase D3 degrades mitochondrial DNA to regulate nucleotide signaling and APP metabolism(2023)
Authors: Zoë Van Acker, Anna Perdok, Katherine North, Jonas Dehairs, Johan Swinnen, Wim Annaert
- Inter-organellar Communication in Parkinson's and Alzheimer's Disease: Looking Beyond Endoplasmic Reticulum-Mitochondria Contact Sites(2022)
Authors: Stephanie Vrijsen, Céline Vrancx, Mara Del Vecchio, Johan Swinnen, Patrizia Agostinis, Joris Winderickx, Peter Vangheluwe, Wim Annaert
- The microglial lysosomal system in Alzheimer's disease: Guardian against proteinopathy(2021)
Authors: Zoë Van Acker, Anna Perdok, Marine Bretou, Wim Annaert
- Study of the neuronal molecular mechanisms in TAU uptake(2021)
Authors: Alberto Carpinteiro, Wim Annaert
- Assembly of γ-secretase occurs through stable dimers after exit from the endoplasmic reticulum(2021)
Authors: Rosanne Wouters, Wim Annaert
- BNIP3 promotes HIF-1α-driven melanoma growth by curbing intracellular iron homeostasis(2021)
Authors: Matteo Rossi, Chris Van den Haute, Maria Livia Sassano, Abhishek Garg, Francesca Bosisio, Jasper Wouters, Peter Vangheluwe, Wim Annaert, Johan Swinnen, Joost van den Oord, et al.
Patents
1 - 9 of 9
- Gamma-secretase inhibitor screening assay (Inventor)
- Screening methods for compounds modulating polyamine transport (Inventor)
- Gamma-secretase inhibitor screening assay (Inventor)
- Method and apparatus for the imaging of a labeled biological sample (Inventor)
- Bace1 inhibitory antibodies (Inventor)
- BACE1 inhibitory antibodies (Inventor)
- Plasma membrane isolation (Inventor)
- Plasma membrane isolation (Inventor)
- SCREENING METHODS FOR COMPOUNDS THAT MODULATE ARF-6 MEDIATED ENDOSOMAL REDISTRIBUTION (Inventor)