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Project

Lysosomal Homeostasis in Alzheimer's disease

The propagation of Alzheimer’s disease (AD) is partially based on exo/endocytosis process promoting the spread of tau and A oligomers which are the main proteins hallmark of the disease. Previous studies identified several genes as risk factors for late onset Alzheimer’s disease (LOAD). One of these genes is PLD-3 involved in lysosomal regulation however its functions are still misunderstood. The main goal of this project will be to understand in which proportions the endo-lysosomal dysfunction is involved in LOAD. To assess that, we will use human neurons as well as mice models combined with molecular and cellular biological approaches. During this project, we will have three main objectives. First, we will elucidate PLD3’s role in endo-lysosomal transport regulation and homeostasis. Second, we will investigate the impact of PLD3 deficit on lysosomal homeostasis via subcellular omics profiling. Finally, we will validate the identified targets in vitro and in vivo. If successful, this project may develop into a standardized technological platform for systematically screening risk factors in LOAD as well as in other neurodegenerative diseases

Date:25 Sep 2020 →  11 Dec 2020
Keywords:Alzheimer
Disciplines:Neurological and neuromuscular diseases
Project type:PhD project