Researcher
Wim Annaert
- Disciplines (Flanders Institute for Biotechnology):Analysis of next-generation sequence data, Cell death, Behavioural neuroscience
- Disciplines (KU Leuven):Intracellular compartments and transport
- See also: Annaert Wim (Flanders Institute for Biotechnology)
Affiliations
- Laboratory of Membrane Trafficking (VIB-KU Leuven) (Lab)
Responsible
From1 Jan 2006 → Today - Laboratory of Membrane Trafficking (VIB-KU Leuven) (Lab)
Member
From1 Jan 2017 → Today - Annaert Lab (Research group)
Responsible
From1 Jan 2017 → Today - Department of Human Genetics (Department)
Member
From1 Oct 1999 → 31 Dec 2016
Projects
41 - 45 of 45
- Nanodomain targeting and localization of distinct gamma-secretase complexes versus APP.From1 Jan 2009 → 31 Dec 2014Funding: FWO research project (including WEAVE projects)
- Exploring the endocytic route of ICAM-5 in hippocampal neurons - a strategy to reveal the y-secretase independent role of presenilin 1 in trafficking.From1 Jan 2009 → 31 Dec 2011Funding: DWTC (Federal Science Policy Office) - return mandates
- New microscopy modalities for diffraction unlimited optical imaging.From20 Oct 2008 → 19 Apr 2015Funding: Hercules - Small and Medium size research infrastructure
- Exploring the endocytic route of ICAM-5 in hippocampal neurons - a strategy to reveal the gamma-secretase independent role of presenilin 1 in protein trafficking.From1 Aug 2008 → 1 Jul 2015Funding: FWO fellowships
- Genetic screen for modulators of dendritic arborization among members of small GTPases families membersFrom19 Mar 2008 → 15 Mar 2009Funding: Own budget, for example: patrimony, inscription fees, gifts
Publications
1 - 10 of 89
- Accumulation of APP C-terminal fragments causes endolysosomal dysfunction through the dysregulation of late endosome to lysosome-ER contact sites.(2024)
Authors: Zoë Van Acker, Anna Perdok, Wim Annaert
Pages: S1534-5807 - Maintenance of proteostasis by Drosophila Rer1 is essential for competitive cell survival and Myc-driven overgrowth.(2024)
Authors: Wim Annaert
Pages: e1011171 - A TCF4-dependent gene regulatory network confers resistance to immunotherapy in melanoma(2024)
Authors: Dennis Pedri, Ewout Landeloos, Yannick Van Herck, Katy Vandereyken, Thierry Voet, Wim Annaert, Diether Lambrechts, Veerle Boecxstaens, Joost van den Oord, Francesca Bosisio, et al.
- Deciphering melanoma transcriptional heterogeneity: TCF4 and the mesenchymal-like switch(2023)
Authors: Dennis Pedri, Wim Annaert, Chris Marine
- Phospholipase D3 degrades mitochondrial DNA to regulate nucleotide signaling and APP metabolism(2023)
Authors: Zoë Van Acker, Anna Perdok, Katherine North, Jonas Dehairs, Johan Swinnen, Wim Annaert
- Inter-organellar Communication in Parkinson's and Alzheimer's Disease: Looking Beyond Endoplasmic Reticulum-Mitochondria Contact Sites(2022)
Authors: Stephanie Vrijsen, Céline Vrancx, Mara Del Vecchio, Johan Swinnen, Patrizia Agostinis, Joris Winderickx, Peter Vangheluwe, Wim Annaert
- The microglial lysosomal system in Alzheimer's disease: Guardian against proteinopathy(2021)
Authors: Zoë Van Acker, Anna Perdok, Marine Bretou, Wim Annaert
- Study of the neuronal molecular mechanisms in TAU uptake(2021)
Authors: Alberto Carpinteiro, Wim Annaert
- Assembly of γ-secretase occurs through stable dimers after exit from the endoplasmic reticulum(2021)
Authors: Rosanne Wouters, Wim Annaert
- BNIP3 promotes HIF-1α-driven melanoma growth by curbing intracellular iron homeostasis(2021)
Authors: Matteo Rossi, Chris Van den Haute, Maria Livia Sassano, Abhishek Garg, Francesca Bosisio, Jasper Wouters, Peter Vangheluwe, Wim Annaert, Johan Swinnen, Joost van den Oord, et al.
Patents
1 - 9 of 9
- Gamma-secretase inhibitor screening assay (Inventor)
- Screening methods for compounds modulating polyamine transport (Inventor)
- Gamma-secretase inhibitor screening assay (Inventor)
- Method and apparatus for the imaging of a labeled biological sample (Inventor)
- Bace1 inhibitory antibodies (Inventor)
- Plasma membrane isolation (Inventor)
- BACE1 inhibitory antibodies (Inventor)
- Plasma membrane isolation (Inventor)
- SCREENING METHODS FOR COMPOUNDS THAT MODULATE ARF-6 MEDIATED ENDOSOMAL REDISTRIBUTION (Inventor)