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Researcher
Wim Annaert
- Disciplines (Flanders Institute for Biotechnology):Analysis of next-generation sequence data, Cell death, Behavioural neuroscience
- Disciplines (KU Leuven):Intracellular compartments and transport
- See also: Annaert Wim (Flanders Institute for Biotechnology)
Affiliations
- Laboratory of Membrane Trafficking (VIB-KU Leuven) (Lab)
Responsible
From1 Jan 2006 → Today - Laboratory of Membrane Trafficking (VIB-KU Leuven) (Lab)
Member
From1 Jan 2017 → Today - Annaert Lab (Research group)
Responsible
From1 Jan 2017 → Today - Department of Human Genetics (Department)
Member
From1 Oct 1999 → 31 Dec 2016
Projects
1 - 10 of 45
- Impact of neuronal lysosomal dysfunction on RNA transport and local translation in Alzheimer’s diseaseFrom15 Nov 2022 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Unraveling a novel role for PSEN2/?-secretase in late endosome/lysosome-endoplasmic reticulum contact sites: impact on Alzheimer’s disease pathogenesisFrom1 Oct 2022 → TodayFunding: FWO junior postdoctoral fellowship
- Unraveling the unprecedented roles for Presenilin/?-secretase in inter-organellar membrane contact sites and how this modulates cellular calcium homeostasisFrom1 Oct 2022 → TodayFunding: FWO senior postdoctoral fellowship
- 3D SUper-Resolution to cryo-Electron MIcroscopy to study nanoscale subcellular dynamics and structure that alter in Neurodegenerative Diseases - 3SURE MINDFrom1 May 2022 → TodayFunding: FWO Large scale research infrastructure
- The impact of lysosomal Phospholipase D3 deficiency on activated response microglia regulationFrom1 Oct 2021 → TodayFunding: FWO fellowships
- Inter-organelle communication through membrane contact sites in oncology and neurodegenerative diseases (InterAction)From1 Oct 2021 → TodayFunding: Fund Recuperation Fiscal Exemption, BOF - projects
- The role of Rer1 in ER-related homeostatic mechanismsFrom1 Jan 2021 → 31 Dec 2021Funding: Own budget, for example: patrimony, inscription fees, gifts
- Dynamic super-resolution microscopy: a gateway for cell biologists to understand molecular machines at work in living cells during homeostasis & diseaseFrom1 Jan 2021 → 31 Dec 2022Funding: BOF - scientific equipment program
- The lysosomal exonuclease PLD3 as an endolysosomal flux regulator: impact on neuronal homeostasis and relevance in neurodegeneration.From1 Oct 2020 → 30 Sep 2023Funding: FWO junior postdoctoral fellowship
- Lysosomal Homeostasis in Alzheimer's diseaseFrom25 Sep 2020 → 11 Dec 2020Funding: Own budget, for example: patrimony, inscription fees, gifts
Publications
21 - 30 of 87
- Lysosomal integral membrane protein-2 (LIMP-2/SCARB2) is involved in lysosomal cholesterol export(2019)
Authors: Wim Annaert
- Endo-lysosomal dysregulations and late-onset Alzheimer’s disease: impact of genetic risk factors(2019)
Authors: Zoë Van Acker, Marine Bretou, Wim Annaert
- The PIKfyve complex regulates the early melanosome homeostasis required for physiological amyloid formation(2019)
Authors: Wim Annaert
- The PIKfyve complex regulates the early melanosome homeostasis required for physiological amyloid formation (vol 132, jcs229500, 2019)(2019)
Authors: Christin Bissig, Pauline Croise, Xavier Heiligenstein, Ilse Hurbain, Guy M Lenk, Emily Kaufman, Ragna Sannerud, Wim Annaert, Miriam H Meisler, Lois S Weisman, et al.
- Paradoxical effects of mutant ubiquitin on Aβ plaque formation in an Alzheimer mouse model(2018)
Authors: Wim Annaert
Pages: 62 - 71 - Nonselective Chemical Inhibition of Sec7 Domain-Containing ARF GTPase Exchange Factors(2018)
Authors: Marine Bretou, Wim Annaert
Pages: 2573 - 2593 - Organellar OmicsA Reviving Strategy to Untangle the Biomolecular Complexity of the Cell(2018)
Authors: Wim Annaert
- Characterization of Influenza Virus Pseudotyped with Ebolavirus Glycoprotein(2018)
Authors: Wim Annaert
- Endosome to trans-Golgi network transport of Proprotein Convertase 7 is mediated by a cluster of basic amino acids and palmitoylated cysteines(2017)
Authors: Jeroen Declercq, Bruno Ramos Molina, Wim Annaert, John Creemers
Pages: 432 - 439 - The ER Stress Sensor PERK Coordinates ER-Plasma Membrane Contact Site Formation through Interaction with Filamin-A and F-Actin Remodeling(2017)
Authors: Alex van Vliet, Geert Molenberghs, Susana Neves Rocha, Rita Derua, Tom Verfaillie, Herlinde De Keersmaecker, Etienne Waelkens, Johan Hofkens, Wim Annaert, Peter Carmeliet, et al.
Pages: 885 - 899
Patents
1 - 9 of 9
- Gamma-secretase inhibitor screening assay (Inventor)
- Screening methods for compounds modulating polyamine transport (Inventor)
- Gamma-secretase inhibitor screening assay (Inventor)
- Method and apparatus for the imaging of a labeled biological sample (Inventor)
- Bace1 inhibitory antibodies (Inventor)
- BACE1 inhibitory antibodies (Inventor)
- Plasma membrane isolation (Inventor)
- Plasma membrane isolation (Inventor)
- SCREENING METHODS FOR COMPOUNDS THAT MODULATE ARF-6 MEDIATED ENDOSOMAL REDISTRIBUTION (Inventor)