Researcher
Wim Annaert
- Disciplines (Flanders Institute for Biotechnology):Analysis of next-generation sequence data, Cell death, Behavioural neuroscience
- Disciplines (KU Leuven):Intracellular compartments and transport
- See also: Annaert Wim (Flanders Institute for Biotechnology)
Affiliations
- Laboratory of Membrane Trafficking (VIB-KU Leuven) (Lab)
Responsible
From1 Jan 2006 → Today - Laboratory of Membrane Trafficking (VIB-KU Leuven) (Lab)
Member
From1 Jan 2017 → Today - Annaert Lab (Research group)
Responsible
From1 Jan 2017 → Today - Department of Human Genetics (Department)
Member
From1 Oct 1999 → 31 Dec 2016
Projects
1 - 10 of 45
- Impact of neuronal lysosomal dysfunction on RNA transport and local translation in Alzheimer’s diseaseFrom15 Nov 2022 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Unraveling a novel role for PSEN2/?-secretase in late endosome/lysosome-endoplasmic reticulum contact sites: impact on Alzheimer’s disease pathogenesisFrom1 Oct 2022 → TodayFunding: FWO junior postdoctoral fellowship
- Unraveling the unprecedented roles for Presenilin/?-secretase in inter-organellar membrane contact sites and how this modulates cellular calcium homeostasisFrom1 Oct 2022 → TodayFunding: FWO senior postdoctoral fellowship
- 3D SUper-Resolution to cryo-Electron MIcroscopy to study nanoscale subcellular dynamics and structure that alter in Neurodegenerative Diseases - 3SURE MINDFrom1 May 2022 → TodayFunding: FWO Large scale research infrastructure
- The impact of lysosomal Phospholipase D3 deficiency on activated response microglia regulationFrom1 Oct 2021 → TodayFunding: FWO fellowships
- Inter-organelle communication through membrane contact sites in oncology and neurodegenerative diseases (InterAction)From1 Oct 2021 → TodayFunding: Fund Recuperation Fiscal Exemption, BOF - projects
- The role of Rer1 in ER-related homeostatic mechanismsFrom1 Jan 2021 → 31 Dec 2021Funding: Own budget, for example: patrimony, inscription fees, gifts
- Dynamic super-resolution microscopy: a gateway for cell biologists to understand molecular machines at work in living cells during homeostasis & diseaseFrom1 Jan 2021 → 31 Dec 2022Funding: BOF - scientific equipment program
- The lysosomal exonuclease PLD3 as an endolysosomal flux regulator: impact on neuronal homeostasis and relevance in neurodegeneration.From1 Oct 2020 → 30 Sep 2023Funding: FWO junior postdoctoral fellowship
- Lysosomal Homeostasis in Alzheimer's diseaseFrom25 Sep 2020 → 11 Dec 2020Funding: Own budget, for example: patrimony, inscription fees, gifts
Publications
31 - 40 of 87
- Tetraspanin 6: a pivotal protein of the multiple vesicular body determining exosome release and lysosomal degradation of amyloid precursor protein fragments(2017)
Authors: Francesc Guix, Amaia Arranz Mendiguren, Amantha Thathiah, Sebastian Munck, Isabel Salas Hernández, Wim Annaert, Bart De Strooper
Pages: 25 - A novel approach to analyze lysosomal dysfunctions through subcellular proteomics and lipidomics: the case of NPC1 deficiency(2017)
Authors: Jean-Paul Decuypere, Shaun Martin, Peter Vangheluwe, Johan Swinnen, Liesbet Lagae, Wim Annaert
Pages: 41408 - 41408 - Bin1 and CD2AP polarize Aβ generation in neurons(2017)
Authors: Wim Annaert
Pages: 5 - 7 - Tetraspanin 8 is an interactor of the metalloprotease meprin β within tetraspanin-enriched microdomains(2016)
Authors: Wim Annaert
Pages: 857 - 69 - Inhomogeneity Based Characterization of Distribution Patterns on the Plasma Membrane(2016)
Authors: Laura Paparelli, Wim Annaert, Sebastian Munck
- Restricted Location of PSEN2/γ-Secretase Determines Substrate Specificity and Generates an Intracellular Aβ Pool(2016)
Authors: Arunkumar Tharkeshwar Raghunath, Roger Habets, Rosanne Wouters, Sebastian Munck, Rita Derua, Etienne Waelkens, Mathieu Bollen, Joost Schymkowitz, Frederic Rousseau, Bart De Strooper, et al.
Pages: 193 - 208 - Using miRNA-mRNA Interaction Analysis to Link Biologically Relevant miRNAs to Stem Cell Identity Testing for Next-Generation Culturing Development(2016)
Authors: Marian Crabbé, Jef Pinxteren, Wim Annaert
Pages: 709 - 722 - Analyzing protein clusters on the plasma membrane: application of spatial statistical analyses on super-resolution microscopy images(2016)
Authors: Laura Paparelli, Wim Annaert, Sebastian Munck
Pages: 95 - 122 - Primary cilium suppression by SREBP1c involves distortion of vesicular trafficking by PLA2G3(2015)
Authors: Hannah Laura Gijs, Niamat Khan, Jonas Dehairs, Rita Derua, Etienne Waelkens, Patrizia Agostinis, Wim Annaert, Johan Swinnen
Pages: 2321 - 2332 - Early etiology of Alzheimer's disease: tipping the balance toward autophagy or endosomal dysfunction(2015)
Authors: Aleksandar Peric, Wim Annaert
Pages: 363 - 381
Patents
1 - 9 of 9
- Gamma-secretase inhibitor screening assay (Inventor)
- Screening methods for compounds modulating polyamine transport (Inventor)
- Gamma-secretase inhibitor screening assay (Inventor)
- Method and apparatus for the imaging of a labeled biological sample (Inventor)
- Bace1 inhibitory antibodies (Inventor)
- BACE1 inhibitory antibodies (Inventor)
- Plasma membrane isolation (Inventor)
- Plasma membrane isolation (Inventor)
- SCREENING METHODS FOR COMPOUNDS THAT MODULATE ARF-6 MEDIATED ENDOSOMAL REDISTRIBUTION (Inventor)