Researcher
Wim Annaert
- Disciplines (Flanders Institute for Biotechnology):Analysis of next-generation sequence data, Cell death, Behavioural neuroscience
- Disciplines (KU Leuven):Intracellular compartments and transport
- See also: Annaert Wim (Flanders Institute for Biotechnology)
Affiliations
- Laboratory of Membrane Trafficking (VIB-KU Leuven) (Lab)
Responsible
From1 Jan 2006 → Today - Laboratory of Membrane Trafficking (VIB-KU Leuven) (Lab)
Member
From1 Jan 2017 → Today - Annaert Lab (Research group)
Responsible
From1 Jan 2017 → Today - Department of Human Genetics (Department)
Member
From1 Oct 1999 → 31 Dec 2016
Projects
21 - 30 of 45
- Bridging microscopy with nanotechnology and interactomics to probe the membrane microenvironment of distinct y-secretase complexes in cells and neurons and to identify complex-specific interactorsFrom1 Jan 2017 → 31 Dec 2020Funding: FWO research project (including WEAVE projects)
- Addition of ImageStream facilities to the FACS CoreFrom1 Oct 2016 → 30 Sep 2018Funding: Fund Recuperation Fiscal Exemption
- Study of the molecular mechanisms in Tau propagationFrom24 Mar 2016 → 31 Aug 2020Funding: Baekeland
- Regulation of vesicular trafficking in melanoma and its driving role in melanoma plasticity and progressionFrom5 Oct 2015 → 25 Feb 2021Funding: FWO fellowships
- Cell biology of the endo-/lysosomal proteostasis in cancer and neurodegeneration (LYSOCaN).From1 Oct 2015 → 30 Sep 2021Funding: BOF - Concerted Research Project from 1994
- An image storage platform for analysis management and mining.From10 Sep 2014 → 9 Mar 2019Funding: Hercules - Small and Medium size research infrastructure
- Spatial-temporal dissection of organelle-specific y-secretase interactomes using nanotechnologyFrom1 Sep 2014 → 22 Mar 2021Funding: FWO fellowships
- Visualizing γ-secretase at single-molecule resolutionFrom1 Jan 2014 → 20 Jan 2021Funding: Own budget, for example: patrimony, inscription fees, gifts
- Lipid-mediated cilium loss in cancer cells as a novel driver of cellular autonomy and potential target for interventionFrom1 Jan 2013 → 31 Dec 2016Funding: FWO research project (including WEAVE projects)
- Do presenilin-dependent defects in endosomal recycling contribute to neurodegeneration in aging and early onset of Alzheimers disease?From1 Oct 2012 → 30 Apr 2013Funding: BOF - Other initiatives
Publications
1 - 10 of 87
- Maintenance of proteostasis by Drosophila Rer1 is essential for competitive cell survival and Myc-driven overgrowth.(2024)
Authors: Wim Annaert
Pages: e1011171 - A TCF4-dependent gene regulatory network confers resistance to immunotherapy in melanoma(2024)
Authors: Dennis Pedri, Ewout Landeloos, Yannick Van Herck, Katy Vandereyken, Thierry Voet, Wim Annaert, Diether Lambrechts, Veerle Boecxstaens, Joost van den Oord, Francesca Bosisio, et al.
- Phospholipase D3 degrades mitochondrial DNA to regulate nucleotide signaling and APP metabolism(2023)
Authors: Zoë Van Acker, Katherine North, Jonas Dehairs, Johan Swinnen, Wim Annaert
- Inter-organellar Communication in Parkinson's and Alzheimer's Disease: Looking Beyond Endoplasmic Reticulum-Mitochondria Contact Sites(2022)
Authors: Stephanie Vrijsen, Céline Vrancx, Mara Del Vecchio, Johan Swinnen, Patrizia Agostinis, Joris Winderickx, Peter Vangheluwe, Wim Annaert
- The microglial lysosomal system in Alzheimer's disease: Guardian against proteinopathy(2021)
Authors: Zoë Van Acker, Anna Perdok, Marine Bretou, Wim Annaert
- Study of the neuronal molecular mechanisms in TAU uptake(2021)
Authors: Alberto Carpinteiro, Wim Annaert
- Assembly of γ-secretase occurs through stable dimers after exit from the endoplasmic reticulum(2021)
Authors: Rosanne Wouters, Wim Annaert
- BNIP3 promotes HIF-1α-driven melanoma growth by curbing intracellular iron homeostasis(2021)
Authors: Matteo Rossi, Chris Van den Haute, Maria Livia Sassano, Abhishek Garg, Francesca Bosisio, Jasper Wouters, Peter Vangheluwe, Wim Annaert, Johan Swinnen, Joost van den Oord, et al.
- The role of Bcl-2 proteins in modulating neuronal Ca2+ signaling in health and in Alzheimer's disease(2021)
Authors: Manon Callens, Wim Annaert, Geert Bultynck, Tim Vervliet
- The Nanoscopic Organization of Synapse Structures: A Common Basis for Cell Communication(2021)
Authors: Xiaojuan YANG, Wim Annaert
Patents
1 - 9 of 9
- Gamma-secretase inhibitor screening assay (Inventor)
- Screening methods for compounds modulating polyamine transport (Inventor)
- Gamma-secretase inhibitor screening assay (Inventor)
- Method and apparatus for the imaging of a labeled biological sample (Inventor)
- Bace1 inhibitory antibodies (Inventor)
- Plasma membrane isolation (Inventor)
- BACE1 inhibitory antibodies (Inventor)
- Plasma membrane isolation (Inventor)
- SCREENING METHODS FOR COMPOUNDS THAT MODULATE ARF-6 MEDIATED ENDOSOMAL REDISTRIBUTION (Inventor)